Developing novel molecules that target hormone receptors as an alternative cancer therapy [ 2013 - 2015 ]

Research Grant

Researchers: A/Pr Shelli Mcalpine (Principal investigator) ,  Prof Paul Workman

Brief description A promising class of cancer drugs target heat shock protein 90 (Hsp90) and prevent Hsp90 from maintaining its ~100 proteins involved in cell growth. However, all current Hsp90 chemotherapeutics non-selectively target proteins maintained by Hsp90, and induce a cell rescue mechanism involving Hsp70. We describe the development of a novel molecule that will selectively control cell growth and prevent cell rescue via a unique Hsp90 regulated mechanism.

Funding Amount $AUD 459,867.40

Funding Scheme Project Grants

Notes Standard Project Grant