Delayed radial glial maturation linked to NFI deficiency as an underlying cause of cortical defects in humans and mice [ 2016 - 2018 ]

Research Grant

Researchers: Prof Linda Richards (Principal investigator) ,  A/Pr Thomas Burne

Brief description The timely generation of neurons and glia is important for brain development and consequently brain function throughout life. Nuclear factor I (NFI) genes are important for regulating the production of neurons and glia, and people with disrupted NFI genes have severe cognitive and motor deficits. Using human genetic data and mouse models, we will analyse how disrupting these genes affects brain development, and changes the overall structure and wiring of the cerebral cortex as well as behaviour.

Funding Amount $AUD 823,857.31

Funding Scheme Project Grants

Notes Standard Project Grant