grant

Respiratory viral infections as triggers of acute severe asthma exacerbations in atopics: mechanistic studies in an experimental model [ 2011 - 2014 ]

Also known as: Studies on the mechanisms by which virus infections trigger severe asthma attacks in subjects with allergies

Funded by National Health and Medical Research Council
Managed by The University of Western Australia
Managed by University of Western Australia
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1008741]

Researchers: Prof Patrick Holt (Principal investigator) ,  Dr Deborah Strickland

Brief description An important unresolved issue in asthma research is why almost all the children who present in hospital emergency with very severe asthma attacks are both allergic and virally infected. This project will seek to define how immune responses to viruses and aeroallergens interact to create very severe inflammation in the airways thus precipitating the severest type of asthma attacks. Understanding the underlying mechanisms will hopefully provide new clues towards better treatments.

Funding Amount $AUD 659,494.63

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Clinical Sciences | Clinical Sciences Not Elsewhere Classified | Medical and Health Sciences | T cell activation | allergic asthma | asthma exacerbation | asthma severity | atopy | dendritic cell | respiratory infection |
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