grant

Roles of the hepatitis C virus glycoprotein E2 variable regions in virus entry, immunogenicity and immune evasion. [ 2012 - 2014 ]

Also known as: Variable regions of HCV glycoprotein E2

Funded by National Health and Medical Research Council
Managed by Macfarlane Burnet Institute for Medical Research and Public Health
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1020175]

Researchers: A/Pr Heidi Drummer (Principal investigator) ,  A/Pr Mandvi Bharadwaj ,  Dr Pantelis Poumbourios

Brief description Hepatitis C Virus infects 200 million people world-wide with over 200,000 Australians infected with the disease. This project will examine how the surface proteins of HCV change their shape to evade antibody responses and how this effects the outcome of infection. We will further characterize a vaccine that elicits protective immunity to HCV to identify the optimal formulation for clinical trials.

Funding Amount $AUD 682,820.65

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Medical and Health Sciences | Medical Microbiology | Medical Virology | antibody | chronic infection | glycoproteins | hepatitis C virus | receptor binding | structure-function | vaccine design | vaccine development |
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