grant

Astrocytes, mutant TDP-43 and non-cell autonomous injury of motoneurons [ 2012 - 2015 ]

Also known as: Contributions of astrocytic TDP-43 to motoneuron disease

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1023780]

Researchers: Prof Philip Beart (Principal investigator) ,  Dr Bradley Turner ,  Dr Hakan Muyderman

Brief description Motor neuron disease (MND) leads to death of nerve cells, paralysis and death. There is no cure. Mutations in the protein TDP43 cause MND. In this study we will investigate the underlying mechanisms of which these mutations cause disease. We will also investigate how these mutations affect astrocytes, a cell type that maintains normal function and survival of nerve cells and determine if the mutations affect the important interactions that normally takes place between these cell types.

Funding Amount $AUD 626,492.27

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Medical and Health Sciences | Neurosciences | Neurology and Neuromuscular Diseases | astrocytes | excitotoxicity | glutamate | inflammation | kinase inhibitors | motor neuron disease (MND) | oxidative stress | protein aggregation | proteomics | signalling |
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