grant

The role of Rnpc3 in U12-type mRNA splicing, gene expression and cancer [ 2012 - 2014 ]

Also known as: Linking a zebrafish intestinal development gene to cancer

Funded by National Health and Medical Research Council
Managed by The Walter and Eliza Hall Institute of Medical Research
Managed by Walter and Eliza Hall Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1024878]

Researchers: A/Pr Joan Heath (Principal investigator)

Brief description The zebrafish is a small tropical fish that is an alternative model to mice for genetic studies. We have used zebrafish to discover genes that are essential for the rapid development of the intestine in the belief that these genes are also essential for tumour growth. We will test whether the loss of RNPC3 (the human version of one of our genes), which is required for the production of a small number of proteins that can suppress the development of cancer, plays a hitherto unappreciated causal role in the development of colon tumours.

Funding Amount $AUD 593,794.21

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Biological Sciences | Developmental Genetics (Incl. Sex Determination) | Genetics | RNA processing | cancer genetics | colon cancer mechanisms | developmental genetics | gene discovery | gene expression | intestine | mouse models | splicing | zebrafish |
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