Functional analysis of the Toxoplasma Myosin driving tissue dissemination and host cell invasion [ 2013 - 2015 ]

Research Grant

Researchers: A/Pr Christopher Tonkin (Principal investigator) ,  A/Pr Michael Lawrence ,  Prof Brian Smith

Brief description The single-celled parasite Toxoplasma gondii is the cause of Toxoplasmosis and is an important basis of eye disease, congenital birth defects and illness in immunocompromised individuals. To perpetuate infection T. gondii moves through tissue and invades host cells using a molecular motor, termed the 'glideosome'. We will reveal how the glideosome produces the force required for movement and characterise its critical features. Our work will provide a foundation in which to model novel drugs that could be designed to treat Toxoplasmosis.

Funding Amount $AUD 763,241.00

Funding Scheme Project Grants

Notes Standard Project Grant