Identification of the Mechanisms of Hepatic Fibrogenesis Aid in the Detection and Prediction of Clinical Outcomes in Paediatric Cholestatic Liver Disease. [ 2013 - 2016 ]

Research Grant

Researchers: Prof Grant Ramm (Principal investigator) ,  A/Pr David Reid ,  A/Pr Peter Lewindon ,  Prof Ross Shepherd

Brief description Biliary Atresia (BA) and Cystic Fibrosis Liver Disease (CFLD) are important causes of childhood cirrhosis. Diagnosis is difficult, treatments problematic, and outcomes suboptimal. In BA, bile duct obstruction in infants rapidly progresses to liver failure. It is the most common indication for liver transplantation in children. CFLD causes significant morbidity/mortality in about 20% of CF children. This proposal investigates the mechanisms of liver fibrosis (scarring) and the role of fibrosis in both diagnosis and predicting clinical outcome.

Funding Amount $AUD 624,429.36

Funding Scheme Project Grants

Notes Standard Project Grant