Glycomic control of cartilage extra cellular matrix turnover [ 2013 - 2016 ]

Research Grant

Researchers: Prof David Smith (Principal investigator) ,  Prof Alan Grodzinsky ,  Prof Bruce Gardiner ,  Prof Deidre Coombe

Brief description Small, naturally occurring glycomic molecules control cartilage matrix turnover. We have synthesised small synthetic analogues of the naturally occurring molecules, and demonstrated their ability to regulate signalling pathways. This project will test and mathematical model the synthetic molecules in cell and tissue assays to define their properties and tissue effects, and assess their suitability as a drug delivery system. The results will be an important step towards designing new ways of treating osteoarthritis and other cartilage diseases.

Funding Amount $AUD 706,289.25

Funding Scheme Project Grants

Notes Standard Project Grant