Optimising combinations of calcium channel inhibitors for treatment of secondary degeneration after neurotrauma [ 2014 - 2016 ]

Research Grant

Researchers: Prof Melinda Fitzgerald (Principal investigator) ,  A/Pr Livia Hool ,  A/Pr Matthew Kilburn ,  A/Pr Stuart Hodgetts ,  Prof Sarah Dunlop

Brief description Traumatic injury to the central nervous system is made worse by damage that spreads away from the initial point of impact. Excess calcium entering cells is a key contributor to spreading damage but treatment with single calcium channel inhibitors has been disappointing. We will use combinations of calcium channel inhibitors to block multiple calcium channels and ensure the optimised combination is effective in clinically relevant models of neurotrauma.

Funding Amount $AUD 679,772.05

Funding Scheme Project Grants

Notes Standard Project Grant