The L-type calcium channel as a reporter of successful morpholino oligomer therapy in treatment of Duchenne Muscular Dystrophy cardiomyopathy [ 2014 - 2016 ]

Research Grant

Researchers: A/Pr Livia Hool (Principal investigator) ,  Prof Stephen Wilton ,  Prof Sue Fletcher

Brief description Duchenne Muscular Dystrophy is a fatal muscle wasting disorder. We have previously characterised how the heart fails in a mouse model of muscular dystrophy. We now have preliminary data demonstrating that treatment of mice with morpholino oligomers can rescue cardiac function. This project will fully characterise the effect of the treatment on heart function and optimise therapy regimes with the view to utilising the optimised protocol as a guideline in treating cardiomyopathy in Duchenne Muscular Dystrophy boys.

Funding Amount $AUD 595,062.17

Funding Scheme Project Grants

Notes Standard Project Grant