Repair of epigenetic abnormalities in human induced pluripotent stem cells by targeted epigenome engineering [ 2014 - 2016 ]

Research Grant

Researchers: Prof Ryan Lister (Principal investigator) ,  A/Pr Jose Polo ,  A/Pr Killugudi Swaminatha-Iyer ,  A/Pr Pilar Blancafort

Brief description New advances enable a patient’s cells to be reprogrammed into an adult stem cell, with the capacity to turn into any specialized cell type to replace a patient’s damaged cells. However, we have discovered that adult stem cells are flawed, they have an epigenetic memory of their past specialized form that limits their capacity to transform into other specialized cells. We will use a novel molecular tool to erase this memory, thus repairing adult stem cells for their use in regenerative medicine.

Funding Amount $AUD 810,366.45

Funding Scheme Project Grants

Notes Standard Project Grant