The role of co-signalling receptors in cytotoxic lymphocyte activity during infection and cancer [ 2015 - 2017 ]

Research Grant

Researchers: Dr Jane Oliaro (Principal investigator) ,  A/Pr Phillip Darcy

Brief description Cytotoxic lymphocytes (CLs) are immune cells that detect and kill cancer cells. CLs recognise ‘stress’ proteins on cancer cells through specialised receptors, and this provides the signal for them to kill. However, some cancer cells, such as leukemic cells, can interfere with this recognition to avoid killing by immune cells. This project will investigate the mechanism of recognition and killing of cancer cells by CLs, using both mouse models and cells from patients with acute myeloid leukemia.

Funding Amount $AUD 739,657.56

Funding Scheme Project Grants

Notes Standard Project Grant