Molecular basis of Ca2+-dependent disruption of EC-coupling and weakness in skeletal muscle [ 2015 - 2018 ]

Research Grant

Researchers: Prof Graham Lamb (Principal investigator) ,  A/Pr Robyn Murphy ,  Prof Michael Mckenna

Brief description One major cause of weakness in skeletal muscle appears to stem from damage to the mechanism controlling release of calcium ions from internal stores and consequent contraction. This project examines whether the damage is due to excessive levels of intracellular calcium ions activating enzymes that cut a particular vital molecule controlling calcium release. The findings could identify a major factor in muscle weakness in muscular dystrophy and other conditions and lead to specific therapies.

Funding Amount $AUD 530,976.42

Funding Scheme Project Grants

Notes Standard Project Grant