Co-operation between GATA2 mutation or expression and RAS signalling in AML [ 2015 - 2017 ]

Research Grant

Researchers: Prof Hamish Scott (Principal investigator) ,  A/Pr Ian Lewis ,  Dr Anna Brown ,  Dr Christopher Hahn ,  Prof Richard D'Andrea

Brief description We have identified a gene GATA2 which, when mutated, can lead to leukaemia (blood cancer). We will collect samples worldwide from families and individuals that carry GATA2 mutations and have developed leukaemia, and will screen for other genetic changes that contribute to leukaemia. We have also identified a novel group of patients who have a low GATA2 activity and who also have mutations in the RAS gene, a known contributor to leukaemia. We will determine how these cooperate to cause leukaemia.

Funding Amount $AUD 860,601.21

Funding Scheme Project Grants

Notes Standard Project Grant