The Role of 'Orphan' Transporters in Bone Homeostasis and Disease [ 2018 - 2020 ]

Research Grant

Researchers: A/Pr Nathan Pavlos (Principal investigator) ,  A/Pr Rohan Teasdale ,  Prof Jiake Xu

Brief description Osteoclasts (OCs) are giant multinucleated cells exclusively responsible for physiological bone degradation (resorption). Excessive OC activity leads to localised bone destruction (osteolysis) as observed in patients with osteoarthritis and underlies decreased bone mass and fragility fractures that are a hallmark of osteoporosis. This project examines the role of an orphan solute carrier transporter in OC function and its potential involvement in bone disease.

Funding Amount $AUD 685,127.76

Funding Scheme Project Grants

Notes Standard Project Grant