Targeting neuroserpin-plasmin interactions to protect the retina in glaucoma [ 2018 - 2020 ]

Research Grant

Researchers: Prof Stuart Graham (Principal investigator) ,  Dr Vivek Gupta ,  Prof Mark Baker

Brief description Glaucoma causes blindness and despite our best treatment many patients continue to progress. A new approach is needed to protect the cells that die in the retina. We have established that a common protease – plasmin – is involved in the process, and a protein that normally regulates it – neuroserpin – is downregulated in the disease. We aim to modify neuroserpin using an ocular gene therapy approach and show it could be used as a novel therapy in glaucoma.

Funding Amount $AUD 648,965.07

Funding Scheme Project Grants

Notes Standard Project Grant