Research Grant
[Cite as http://purl.org/au-research/grants/nhmrc/139021]Researchers: Dr Robin Scaife (Principal investigator) , Prof Wallace Langdon
Brief description Changes in cell adhesion and motility have been implicated in a wide range of human pathologies (e.g. immune, reproductive, mental, and cancerous disorders) . Cell adhesion and motility are tightly regulated by a group of proteins known as Rho-GTPases. Novel pharmacological agents that target signalling by Rho-GTPases have been demonstrated to profoundly affect tumour metastasis, as well as central nervous system regeneration following injury. Further exploitation of Rho-GTPase signal modulation, by detailed studies of the molecular mechanisms involved, could lead to significant advances in medical sciences. In particular, treatment of cancer and spinal injuries are likely to benefit from further development of Rho-signalling research.
Funding Amount $AUD 256,527.54
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- PURL : http://purl.org/au-research/grants/nhmrc/139021
- nhmrc : 139021