Research Grant
[Cite as http://purl.org/au-research/grants/nhmrc/211999]Researchers: A/Pr Delia Nelson (Principal investigator) , Prof Bruce Robinson
Brief description It is becoming increasingly clear that cancerous tissues are not hidden from the body's immune system and yet, despite the generation of tumour-specific T cells and antibodies, the immune system does not often destroy solid tumour. Tumours express a large number of potential antigens (molecules in or on cancer cells that can be recognised by the immune system), but T cell responses to tumour antigens may be limited to only a few of these antigens (the dominating ones). These T cells could compete with any other T cells that have been, or are being, generated, preventing their expansion and development into fully functional T cells. If this is true, then tumours will 'escape' immune mediated destruction, as a T cell response to only a few antigens is not likely to be enought to seriously perturb growing tumours. In this grant we will use a well established mouse model of cancer to evaluate immune responses to tumour antigens during tumour growth and try to understand why other potential antigens do not invoke a fully functional immune response. If we are successful, we will have made advances that could lead to new therapies for cancer.
Funding Amount $AUD 451,980.00
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- PURL : http://purl.org/au-research/grants/nhmrc/211999
- nhmrc : 211999