Characterisation of the role & biomarker potential of the novel cell surface protein TTYH2 in renal cell carcinoma [ 2005 - 2007 ]

Research Grant

Researchers: Prof John Hooper (Principal investigator)

Brief description Renal cell carcinoma is the most common cancer of the kidney. One-third of patients upon first diagnosis have secondary tumour sites already within their body as well as new treatment approaches for more advanced disease making them very difficult to cure. An early specific test for this cancer is urgently needed. Our group has identified a new gene called TTYH2 which is highly expressed by renal cell carcinoma tissue samples but not in normal kidney tissues. In this study, we intend to look at the expression of TTYH2 in more clinical samples to determine if TTYH2 will be a useful bio-marker for this cancer. We are also studying the function of this protein in renal cell carcinoma cells to identify the exact role that TTYH2 performs in cancer development and progression. Finally we will look at what other proteins are interacting with TTYH2 in kidney cancer cells. These latter studies will help us to understand the disease process better and may help us design new treatment methods.

Funding Amount $AUD 489,000.00

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant