Cognitive effects of adding ovarian function suppression to adjuvant hormonal therapy in premenopausal breast cancer [ 2007 - 2011 ]

Research Grant

Researchers: Prof Kelly-Anne Phillips (Principal investigator) ,  A/Pr Jurg Bernhard ,  A/Pr Prudence Francis ,  Prof Frances Boyle ,  Prof Paul Maruff

Brief description There is mounting evidence that potentially curative treatment for breast cancer might, in some women, have an adverse effect on their subsequent cognitive function i.e. their memory and ability to think clearly. Thus it is important that when new treatments are being tested, the testing includes collecting information on the effect of the new treatment on a woman's cognitive function. There is currently an ongoing large international study examining whether suppressing ovarian function (and thus decreasing oestrogen levels) in women having treatment for breast cancer will improve their outcomes. However,it is known that oestrogen is important for normal cognitive functioning in premenopausal women so there is some concern that dropping the oestrogen levels in this way might cause impairment in cognitive function. In this sub-study we will compare the cognitive function of women having ovarian function suppression with those who do not, to determine if there are any differences. We will also examine how this might affect quality of life.

Funding Amount $AUD 301,431.23

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant