grant

Modulation of type 1 diabetes development by rotavirus infection [ 2008 - 2010 ]

Also known as: How does infection with rotavirus alter the rate at which mice show diabetes?

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/509008]

Researchers: A/Pr Barbara Coulson (Principal investigator)

Brief description Rotavirus is the main cause of severe diarrhoea in children, and may contribute to progression to type 1 diabetes. We have now shown that rotavirus also modulates diabetes in mice, by a novel mechanism. In this project, the mechanism of this process will be elucidated and the capacity of human rotavirus to affect diabetes will be determined. This study will help determine the design of further human studies, and whether rotavirus vaccines also are possible modulators of diabetes development.

Funding Amount $AUD 413,775.08

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Applied Immunology (Incl. Antibody Engineering, Xenotransplantation and T-Cell Therapies) | Biomedical and Clinical Sciences | Immunology | rotavirus infection | rotavirus infection may be a trigger of type 1 diabetes | rotavirus presence in the pancreas during gastroenteritis | rotavirus vaccination may help prevent type 1 diabetes | type 1 diabetes | viral immunology | virus pathogenesis | virus receptors |
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