grant

Deciphering how PTEN phosphatase mediates excitotoxic neuronal death [ 2008 - 2011 ]

Also known as: Role of PTEN in neuronal cell death

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/509146]

Researchers: A/Pr Heung-Chin Cheng (Principal investigator) ,  Dr Nam Cheung

Brief description In stroke patients, oxygen deprivation indirectly induces massive nerve cell death by activating a cell death-promoting enzyme called PTEN. We aim at unravelling (i) how PTEN is activated by oxygen deprivation, (ii) where the activated PTEN is localised in cells, and (iii) how the activated and optimally localised PTEN induces nerve cell death. The study will benefit development of therapeutic strategies to protect against brain damage in stroke.

Funding Amount $AUD 519,715.21

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Excitotoxicity | Glutamate | Medical Microbiology | Medical Parasitology | Neuronal death | PTEN | Phospholipid phosphatase | cardiac arrest | head and spinal injury | neurodegenerative disease | neuronal death | stroke |
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