Research Grant
[Cite as http://purl.org/au-research/grants/nhmrc/510294]Researchers: A/Pr Ranjit Thomas Grewal (Principal investigator)
Brief description Accumulation of cholesterol is a hallmark of early atherosclerotic lesions, known as foam cell formation. Hence the stimulation of cholesterol removal (efflux) from macrophages has great therapeutic potential. High Density Lipoproteins (HDL) and apolipoprotein A-I (apoA-I) stimulate efflux via activation of HDL-apoA-I receptors and poorly understood signalling pathways. This application is investigating the role of the Ras-MAPK signalling pathway in promoting efflux from late endosomes.
Funding Amount $AUD 276,598.67
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- PURL : http://purl.org/au-research/grants/nhmrc/510294
- nhmrc : 510294