grant

Non-neuronal ATP: regulation of release and action in the bladder [ 2009 - 2012 ]

Also known as: How does ATP signal bladder fullness and how does this go wrong?

Funded by National Health and Medical Research Council
Managed by Bond University
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/527502]

Researchers: Prof Russell Chess-Williams (Principal investigator) ,  A/Pr Kylie Mansfield ,  Dr Rikki Hvorup (Funded by) ,  Prof David Grundy ,  Prof Elizabeth Burcher
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Brief description Incontinence disorders are costly and debilitating. How the bladder signals the normal sensation of fullness as well as the urgent need to void urine (urgency) is still not fully understood. The signaling molecule ATP is released during bladder stretch. Using animal and human bladder, we will study how the bladder lining is involved in this signaling process, by measuring how bladder chemicals interact with stretch to modulate ATP release, and how ATP can influence nerve impulses to the brain.

Funding Amount $AUD 451,553.90

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Medical Biochemistry - Carbohydrates | Medical Biochemistry and Metabolomics | bladder urothelium | human bladder dysfunction | management of urinary tract dysfunction in elderly women | overactive bladder - detrusor overactivity | painful bladder syndrome | purinergic mechanisms | tachykinin receptors | urgency | urinary urge incontinence | vanilloid receptors |
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