grant

Regulation and substrate identification of Parkinsons disease causative Leucine-rich Repeat Kinase 2 (LRRK2) [ 2009 - 2012 ]

Also known as: How active LRRK2 causes Parkinsons disease

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/566743]

Researchers: Dr Janetta Culvenor (Principal investigator) ,  A/Pr Heung-Chin Cheng

Brief description Parkinson's disease afflicts 100,000 Australians. Mutations in the recently identified enzyme Leucine-rich Repeat Kinase-2 are a common cause of Parkinson's disease. This project will use biochemical methods to understand how this brain enzyme causes disease by investigating its enzymology, modes of regulation, and target substrates that it modifies by addition of phosphate groups. Characterization of this enzyme will facilitate design of inhibitors to slow the course of Parkinson's disease.

Funding Amount $AUD 699,456.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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