grant

Mechanisms of virally-induced immunosuppression: effects on DC-NK networks [ 2009 - 2011 ]

Also known as: How cytomegalovirus induces immunosuppression

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/572641]

Researchers: Prof Mariapia Degli-Esposti (Principal investigator) ,  Dr Christopher Andoniou

Brief description Cytomegalovirus (CMV) infection induces immunosuppression that often results in adverse clinical outcomes. Our previous work established that dendritic cells (DC), cells involved in the initiation of immune responses, are a principle target for CMV. This proposal will test the hypothesis that CMV-induced immunosuppression is mediated by viral interference with DC. Understanding the mechanisms involved in the induction of immunosuppression is a crucial step towards developing better therapies.

Funding Amount $AUD 566,308.79

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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