grant

Role of the hypoxia-inducible transcription factor HIF-1a in controlling haematopoietic stem cell fate [ 2010 - 2012 ]

Also known as: Oxygenation of the bone marrow regulates blood cell formation

Funded by National Health and Medical Research Council
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/604303]

Researchers: Prof Jean-Pierre Levesque (Principal investigator) ,  A/Pr Ingrid Winkler

Brief description Haematopoietic stem cells (HSCs) reside in the bone marrow (BM) and make all immune and blood cells. We have found that, in the areas of the BM where HSC normally live, the level of oxygen is very low (hypoxia) and decreases even further when HSC are forced to move into the blood in order to be collected for transplantation. This project is to better understand how oxygenation of the BM controls HSC behaviour and properties, and to evaluate its impact on HSC transplantation.

Funding Amount $AUD 586,428.38

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Related Publications

  • Associated with Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML Hypoxia inducible factor (HIF)-2alpha accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML
    handle : 2440/98199

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Subjects
Bone marrow | Cardiorespiratory Medicine and Haematology | G-CSF | Haematological disorders | Haematology | Haematopoiesis | Haematopoietic stem cell mobilisation | Haematopoietic stem cell transplantation | Hypoxia | Leukocyte trafficking | Medical and Health Sciences | Stem cell niche | Stem cell therapy |
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