Modulation of macrophage function as a therapy for chronic obstructive pulmonary disease (COPD) [ 2010 - 2013 ]

Research Grant

Researchers: Prof Sandra Hodge (Principal investigator) ,  A/Pr Greg Hodge ,  Prof Hubertus Jersmann ,  Prof Mark Holmes ,  Prof Paul Reynolds

Brief description We have established that defective clearance of dying cells by phagocytes in the airway can a) perpetuate inflammation in smokers with-without COPD and b) be improved by administration of therapies (Mannose binding lectin and Procysteine) in a mouse model. The current proposal specifically addresses the role of phagocytes in the ongoing airway damage in our COPD patients, and more thoroughly investigates the mechanisms and effects of administration of relevant new therapies (in a mouse model).

Funding Amount $AUD 435,589.91

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant