grant

Role of endogenous Bcl-2 family proteins in acute myeloid leukaemia [ 2010 - 2012 ]

Also known as: Cell death and leukaemia

Funded by National Health and Medical Research Council
Managed by The Walter and Eliza Hall Institute of Medical Research
Managed by Walter and Eliza Hall Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/637326]

Researchers: Prof Andreas Strasser (Principal investigator) ,  Prof Lorraine Robb (Principal investigator) ,  Dr Stephan Glaser

Brief description Programmed cell death (apoptosis) is crucial for health. Impaired apoptosis can lead to cancer. In blood cancers, mutations that disrupt apoptosis allow cells to survive whilst acquiring additional mutations. Moreover, the mutations prevent most drug treatments for cancer, which act by inducing apoptosis, from working effectively. Our research will investigate the role of apoptosis in tumour development and in sustaining tumour growth. The results will help to identify new cancer therapies.

Funding Amount $AUD 474,033.12

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Haematological Tumours | Medical and Health Sciences | Oncology and Carcinogenesis | apoptosis | blood | cancer and related disorders | cancer chemotherapy | early cancer | gene knock-out | haemopoiesis | leukaemia | leukaemias |
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