Why does endogenous RNA need A-to-I editing? [ 2016 - ]

Research Grant

Researchers: A/Pr Carl Walkley (Principal investigator) ,  A/Pr Kaylene Simpson ,  Dr Jin Billy Li

Brief description We are seeking to understand how the protein ADAR1 functions. When it is mutated, ADAR1 can cause a range of diseases, most notably in a subset of Aicardi-Goutieres syndrome (AGS) patients, an autoimmune disorder affecting the brain, immune system, and skin. We have identified how we think that changes in ADAR1 activity may ultimately cause disease. This application will allow us to test this mechanism experimentally.

Funding Amount $794,332.00

Funding Scheme Project Grants

Notes Standard Project Grant