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Full Record Details
Persistent URL
http://purl.org/net/epubs/work/32205781
Record Status
Checked
Record Id
32205781
Title
A Study of the Production of Neutrons for Boron Neutron Capture Therapy using a Proton Accelerator
Contributors
TR Edgecock
,
JRJ Bennett (STFC Rutherford Appleton Lab.)
,
S Green
,
B Phoenix
,
M Scott
Abstract
Boron Neutron Capture Therapy (BNCT) is a binary cancer therapy particularly well-suited to treating aggressive tumours that exhibit a high degree of infiltration of the surrounding healthy tissue. Such tumours, for example of the brain and lung, provide some of the most challenging problems in oncology. The first element of the therapy is boron-10 which is preferentially introduced into the cancerous cells using a carrier compound. Boron-10 has a very high capture cross-section with the other element of the therapy, thermal neutrons, resulting in the production of a lithium nucleus and an alpha particle which destroy the cell they are created in. However, a large flux of neutrons is required and until recently the only source used was a nuclear reactor. In Birmingham, studies of an existing BNCT facility using a 2.8 MeV proton beam and a solid lithium target have found a way to increase the beam power to a sufficient level to allow clinical trials, while maintaining the target solid. In this paper, we will introduce BNCT, describe the work in Birmingham and compare with other accelerator-driven BNCT projects around the World.
Organisation
ISIS
,
STFC
Keywords
ASTeC 2014-2015
Funding Information
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Language
English (EN)
Type
Details
URI(s)
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Year
Paper In Conference Proceedings
In 5th International Particle Accelerator Conference (IPAC 2014), Dresden, Germany, 15-20 Jun 2014, (2014): 2195-2197.
http://accelconf.…/papers/wepro099.pdf
2014
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