Particle separation in microfluidic devices : SPLITT fractionation and microfluidics

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Persistent URL	http://purl.org/net/epubs/work/34612
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Record Id	34612
Title	Particle separation in microfluidic devices : SPLITT fractionation and microfluidics
Contributors	YH Zhang (CCLRC Daresbury Lab.), RW Barber (CCLRC Daresbury Lab.), DR Emerson (CCLRC Daresbury Lab.)
Abstract	In recent years, microfluidic devices have been increasingly used to separate particles such as colloids, macromolecules, cells, beads and droplets. Miniaturisation often introduces new functionalities and paradigms that are not possible at conventional macroscopic scales. In this paper, split-flow-thin fractionation techniques for particle separation are reviewed and the underlying physics of particle migration is discussed. The potential of these particle separation techniques in the design of integrated microfluidic systems is described. We then illustrate how numerical simulation can provide an increased understanding of the fluid-particle motion. The advantages of numerical simulation for rational design and operation of microfluidic devices are highlighted through two practical examples involving an ultrasonic cell washing system and a quadrupole magnetic flow sorter.
Organisation	CCLRC , CSE , CSE-CEG
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Language	English (EN)

Type	Details	URI(s)	Local file(s)	Year
Journal Article	Current Analytical Chemistry 1 (2005): 345-354.	doi:10.2174/157341105774573983	Zhang_et_al_CAC_2005.pdf	2005