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Full Record Details
Persistent URL
http://purl.org/net/epubs/work/49478
Record Status
Checked
Record Id
49478
Title
Laboratory information management system for membrane protein structure initiative - from gene to crystal
Contributors
PV Troshin (STFC Daresbury Lab.)
,
C Morris (STFC Daresbury Lab.)
,
MZ Papiz (STFC Daresbury Lab.)
,
SM Prince (Manchester U.)
Abstract
Membrane Protein Structure Initiative (MPSI) exploits laboratory competencies to work collaboratively and distribute work among the different sites. This is possible as protein structure determination requires a series of steps, starting with target selection, through cloning, expression, purification, crystallization and finally structure determination. Distributed sites create a unique set of challenges for integrating and passing on information on the progress of targets. This role is played by the Protein Information Management System (PIMS), which is a laboratory information management system (LIMS), serving as a hub for MPSI, allowing collaborative structural proteomics to be carried out in a distributed fashion. It holds key information on the progress of cloning, expression, purification and crystallization of proteins. PIMS is employed to track the status of protein targets and to manage constructs, primers, experiments, protocols, sample locations and their detailed histories: thus playing a key role in MPSI data exchange. It also serves as the centre of a federation of interoperable information resources such as local laboratory information systems and international archival resources, like PDB or NCBI. During the challenging task of PIMS integration, within the MPSI, we discovered a number of prerequisites for successful PIMS integration. In this article we share our experiences and provide invaluable insights into the process of LIMS adaptation. This information should be of interest to partners who are thinking about using LIMS as a data centre for their collaborative efforts.
Organisation
SRS
,
CSE
,
STFC
Keywords
Biology
,
LIMS
Funding Information
Related Research Object(s):
Licence Information:
Language
English (EN)
Type
Details
URI(s)
Local file(s)
Year
Journal Article
Molecular Membrane Biology 25, no. 8 (2008): 639-652.
doi:10.1080/09687680802511766
2008
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