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Full Record Details
Persistent URL
http://purl.org/net/epubs/work/54445
Record Status
Checked
Record Id
54445
Title
Self-assembly of peptide nanotubes in an organic solvent
Contributors
MJ Krysmann
,
V Castelletto
,
JE McKendrick
,
LA Clifton
,
IW Hamley (Pr.Au.)
,
PJF Harris
,
SM King (STFC Rutherford Appleton Lab.)
Abstract
The self-assembly of a modified fragment of the amyloid peptide, based on sequence A(beta)(16-20), KLVFF, extended to give AAKLVFF is studied in methanol. Self-assembly into peptide nanotubes is observed, as confirmed by electron microscopy and small-angle X-ray scattering. The secondary structure of the peptide is probed by FTIR and circular dichroism, and UV/visible spectroscopy provides evidence for the important role of aromatic interactions between phenylalanine residues in driving (beta)-sheet self-assembly. The (beta)-sheets wrap helically to form the nanotubes, the nanotube wall comprising four wrapped (beta)-sheets. At higher concentration, the peptide nanotubes form a nematic phase that exhibits spontaneous flow alignment as observed by small-angle neutron scattering.
Organisation
ISIS
,
ISIS-LOQ
,
STFC
Keywords
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Language
English (EN)
Type
Details
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Year
Journal Article
Langmuir
24, no. 15 (2008): 8158-8162.
doi:10.1021/la800942n
Hamley_Peptide_Nanotube.pdf
2008
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