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Persistent URL
http://purl.org/net/epubs/work/66424
Record Status
Checked
Record Id
66424
Title
Thermoresponsive and Biodegradable Dextran Based Microgels: Synthesis and Structural Investigation
Contributors
SV Ghugare
,
E Chiessi
,
VG Sakai (STFC Rutherford Appleton Lab.)
,
MTF Telling (STFC Rutherford Appleton Lab.)
,
PP Wadgaonkar
,
G Paradossi
Abstract
Nanostructured objects, often ranging from hundreds of nanometers to few microns, support a number of functions directly linked to their structural features. They are, or they will be, protagonists in biomedical applications where miniaturized activities are required. These include the interface with living systems as tissues and cells, where targeted release of drug molecules occurs, or molecular imaging methods monitoring the drug trafficking in specific cell districts. The potentials of such devices, far to be fully understood, will be assessed only when a close correlation of their functions with their structure will be established. In this contribution we present a dextran based microdevice responsive to temperature and biodegradable. Both thermoresponsivity and biodegradability are of relevance for the potential use as drug carrier and controlled release device. The temperature behaviour, overall structure and internal architectures have been addressed with different methods.
Organisation
ISIS
,
ISIS-IRIS
,
STFC
Keywords
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Language
English (EN)
Type
Details
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Year
Journal Article
Macromol Symp
329, no. 1 (2013): 27-34.
doi:10.1002/masy.201300009
2013
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