#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on April 26, 2024; 3:22 GMT TreeBASE (cc) 1994-2008 Study reference: Valles Y., Giani V., Cho S., Seaver E., & Weisblat D. 2010. Evolutionary dynamics of the Wnt gene family: a lophotrochozoan perspective. Molecular Biology and Evolution, . TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S10281] BEGIN TAXA; TITLE Taxa1; DIMENSIONS NTAX=90; TAXLABELS Achaearanea_tepidariorum_wnt2 Acyrthosiphon_pisum_wnt16 Branchiostoma_floridae_wnt1 Branchiostoma_floridae_wnt11 Branchiostoma_floridae_wnt3 Branchiostoma_floridae_wnt4 Branchiostoma_floridae_wnt6 Branchiostoma_floridae_wnt7b Branchiostoma_floridae_wnt8 Capitella_teleta_wnt1 Capitella_teleta_wnt10 Capitella_teleta_wnt11 Capitella_teleta_wnt16 Capitella_teleta_wnt2 Capitella_teleta_wnt4 Capitella_teleta_wnt5 Capitella_teleta_wnt6 Capitella_teleta_wnt7 Capitella_teleta_wnt8 Capitella_teleta_wnt9 Capitella_teleta_wntA Helobdella_robusta_wnt1 Helobdella_robusta_wnt10 Helobdella_robusta_wnt11a Helobdella_robusta_wnt11b Helobdella_robusta_wnt11c Helobdella_robusta_wnt16a Helobdella_robusta_wnt16b Helobdella_robusta_wnt2 Helobdella_robusta_wnt4 Helobdella_robusta_wnt5a Helobdella_robusta_wnt5b Helobdella_robusta_wnt6 Helobdella_robusta_wnt7 Homo_sapiens_wnt1 Homo_sapiens_wnt10a Homo_sapiens_wnt10b Homo_sapiens_wnt11 Homo_sapiens_wnt16 Homo_sapiens_wnt2a Homo_sapiens_wnt2b Homo_sapiens_wnt3 Homo_sapiens_wnt3a Homo_sapiens_wnt4 Homo_sapiens_wnt5a Homo_sapiens_wnt5b Homo_sapiens_wnt6 Homo_sapiens_wnt7a Homo_sapiens_wnt7b Homo_sapiens_wnt8a Homo_sapiens_wnt8b Homo_sapiens_wnt9a Homo_sapiens_wnt9b Lottia_gigantea_wnt1 Lottia_gigantea_wnt10 Lottia_gigantea_wnt11 Lottia_gigantea_wnt16 Lottia_gigantea_wnt2 Lottia_gigantea_wnt4 Lottia_gigantea_wnt5 Lottia_gigantea_wnt6 Lottia_gigantea_wnt7 Lottia_gigantea_wnt9 Lottia_gigantea_wntA Nematostella_vectensis_wnt1 Nematostella_vectensis_wnt10 Nematostella_vectensis_wnt11 Nematostella_vectensis_wnt16 Nematostella_vectensis_wnt2 Nematostella_vectensis_wnt3 Nematostella_vectensis_wnt4 Nematostella_vectensis_wnt5 Nematostella_vectensis_wnt6 Nematostella_vectensis_wnt7 Nematostella_vectensis_wnt8 Nematostella_vectensis_wnt8b Nematostella_vectensis_wntA Strongylocentrotus_purpuratus_wnt10 Strongylocentrotus_purpuratus_wnt3 Strongylocentrotus_purpuratus_wnt5 Tribolium_castaneum_wnt1 Tribolium_castaneum_wnt10 Tribolium_castaneum_wnt11 Tribolium_castaneum_wnt5 Tribolium_castaneum_wnt6 Tribolium_castaneum_wnt7 Tribolium_castaneum_wnt8 Tribolium_castaneum_wnt9 Tribolium_castaneum_wntA Xenopus_tropicalis_wnt16 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M4780] TITLE Metazoan_wnts; LINK TAXA = Taxa1; DIMENSIONS NCHAR=584; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y *" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Achaearanea_tepidariorum_wnt2 TQMLCGGIPGLAR-KQREICEQHPD-ILLSVTKGARIGVSECQAQFRNQRWNCSTLGSGAS--------------------------VFG--SHMLKVDSRESAFLYAISSAGVTHAIIRSCSRGEI-PNCPCDPLR--------RGFGFDP--------------------------------TV-GGYSWGGCS--HISAGVKFARQFIDARED-------RRKD---------------ARALMNFHNNRAGRKAVQKKTRLQCKCHGVSGSCASRTCWSAQMEFR-EVGRLLKRKYE-GAVQVTMSN------------------------------------------------------------------------------------------------------------------------QMALVSV---------DG-TKPYTKLDLIYFESSPDFCAINKSLGTLGTGGRRCDRD-----------SKGVEGCAILCCGKGYDTR--RELFAEKCSC-KFNWCCKVKCKVCREWKDVYTCKHSI*-------------------------- Acyrthosiphon_pisum_wnt16 ARAVCSALPGLAS-KQVDVCMKHPN-AIYSVSDGAKKAIEQCQLQFRHERWNCSVME--------------------------NEQSVFG---PTLDKGSKETAFIYAITSAGVVYSITNACSSGRL-TECSCD-SMQHG-----QTTPEG--------------------------------------WKWGGCS-DNLRFGLQFSRKFVDGSEPNRPDNFKTTKQKRIWSN----------RLKMNLHNNEVGRQIVMSLMKMHCRCHGVSGSCELKTCWKFMPSFN-EIGNELKQKYG-KAILVSLKR--------------------------------------------------------------------------------------------------------------------------LNRRM------------LIESK--ELVHIQKSPNYCKQDFENGVLGTEGRKCNIT-----------STGPDSCNKLCCGRGYITK--VVKEEEHCNC-KFVWCCYVKCDICYKNIEQKSCK*----------------------------- Branchiostoma_floridae_wnt1 TIMLDPKKHPLNK-KQRRLVRRNPGDAGEHRDRRPMLAIKECHHQFSKWRWNCPVNTSDHVN------------------------SVFG--NILLR-GCTQTAFIYAVMSAAVAHEVGRNCAEGTI-ETCSCDYR--------SKGPA-------------------------------------GEDWEWGGCS-DNVEFGKQFAKQFVDAGEK-------TKDS---------------VRYLVNMHNNEAGRVAVAENLRRECKCHGMSGSCTLKTCWMRLPNFR-DVGDSLKEKFD-GASKVAFPDIGNNRGSRAKVT------------------------------------------------------------------------------------------------------------GLVPKN-----------SRHKFPTDNDLVYHERSPNFCRNNPRLGFEGTRGRECNVT-----------SRGLDGCDLLCCGRGYATR--QEVTKERCNC-TFQWCCQVKCEECVRTKTIHTCL*----------------------------- Branchiostoma_floridae_wnt11 KTSSCRKVSGFVP-EQTQLCRRTLE-VMPAVEYAAESARKTCQEQFGNRRWNCSSIKKAPHFM-------------------------ND---LEKGT--KEAAYVHALSSAAVVHTVARACAAGYL-KACTCARN--------PGEKPDG-------------------------------------NYTWGGCG-DNVKFGLEFGSRFADAPMRKKKR-SHTQTL-------------------MNLHNSEAGRLAVQNTMTTKCKCHGVSGSCNVKTCWKSLADLT-EISHELAEKYS-YAIKVV--------------------------------------------------------------------------------------------------------------------------KRKIGTRQ----QLVPEDRRSRRHGSGDLIFVENSPNYCMVNNRKGSYGTTGRLCNKT----------SV-GPDSCQTMCCGRGYNDF--TVTVTERCNC-KYHWCCYVTCDQCTRTEKKYMCK*----------------------------- Branchiostoma_floridae_wnt3 WPVVCSSIPGLVP-RQIRYCRKFHE-IMPFVADGTKLGIRECQHQFRGRRWNCTTVQGQVSIFGPVLDRGNISTTPKTLPRPRAGDSILG--PAVN-RASREAAFVHAITSAGVAYSVTKACAEGTS-PDCGCDNR--------HKGPPG-------------------------------------EGWRWGGCS-EDVLFGTKFSRDFVDARIR-------GRRD---------------GRSAMDRHNNEAGRQSIMKNLQLKCKCHGLSGSCEIKTCWWAQPDFR-TVGNVLKDKYD-SASEMAVERHRKPSGMV---------------------------------------------------------------------------------------------------------------DSLYPRY-----------SFFKAPGKDDLIYFEVSPNFCEPNNSTGSLGTKGRECNIT-----------SQGIDGCQLMCCGRGWNTR--TEMRTEKCHC-QFHWCCYVTCQECQKKHQVHTCK*----------------------------- Branchiostoma_floridae_wnt4 TEDACEKLHGLIS-RQVQICKRNVE-VMDSVKEGARMSIEECQFQFRHRRWNCSTLINRRGPV-------------------------FG-KVLEEGT--REAAFVHSISAAGVAHAVTRACSSGEL-ERCGCNRT--------VRGTIPE-------------------------------------GFHWAGCS-DNFAFGAAFSQTFVDARERGRVAATSSRAL-------------------MNLHNNEAGRRNLVDHMKTECKCHGVSGSCELKTCWRAMPPFR-EVGARLKEKFD-GATEVQ--------------------------------------------------------------------------------------------------------------------------QKKIGSRR----ELVPLNSDFKPHSSSDLVYLDASPDFCVRDTKVGSMGTVGRVC-NK----------TSKAIDGCELLCCGRGYNTH--TREVVERCSC-KFHWCCYVKCKTCRRTVEVHTCK*----------------------------- Branchiostoma_floridae_wnt6 ----------------------------------------------------------------------------------------------------------------------------------RGCDY----------QMKGE--------------------------------SPDG--SWEWGGCG-DDIDFGYTKSREFMDAQTR-------HRSD---------------IRTLLTLHNNEAGRLAEKNFMRTECKCHGLSGSCAVKTCWKKMPIFR-EVGVRLKERFN-GAFQVMGSNNGK---------------------------------------------------------------------------------------------------------------------YLIPVG-----------DTIKAPTAEDLVYTNESPNFCKRNRKTGSQGTKGRACNAT-----------SMGIGGCDLLCCGRGYKER--QVVVGENCKC-RFHWCCVVKCSKCTAVKTVHECL*----------------------------- Branchiostoma_floridae_wnt7b ANIICNRIPGLVP-RQRAICQTRPD-LIVAIGEGAQRGIDECRYQFRHSRWNCTGMDNDN---------------------------VFG--RELRIG-SKEAAFTYAISSAALVHAIVTACSQGNI-SDCGCDRTK--------EG-DLN-----------------------------------DEGWKWGGCS-ADVKYGLRFCKKFVDARE--------VEQN---------------ARALMNLHNNEAGRKVIDQHTRLECKCHGVSGSCTMKTCWITLPRFR-EVGNILKEKYHHDAQLVEAVRAR---------------------------------------------------------------------------------------------------------------RTRRPTFLKLKN-S---------RT-FEKPREISLVYLRGSPNYCERDEATGSLGTHGRRCNRT-----------SPYQDGCDLMCCGRGYNTH--QFVKTWQCNC-KFHWCCYVKCNQCSERTEEYTCK*----------------------------- Branchiostoma_floridae_wnt8 ADSNGWTLQSNFLITGPKSSFQASLTYASSVAAGAQTAMEECKHQFSWDRWNCTDNALSMFKPN------------------------------TLP-ANREASFVHAISAAGVMYVLTRNCSKGAF-EQCGCD--------LTNNGKKAEG------------------------------------GWTWGGCS-DDIAFGERISKMYSDGVENGQ-----------------------DARAAMNLHNNDVGRKAVRQTMKRVCKCHGVSGSCTTKTCWLQLADFR-AIGVFLKKKYK-KADKVDYV-------------------------------------------------------------------------------------------------------------------------RGQLTENNSASSKRNTG------LKKDMVFLEDSPDYCRENLTVGSRGTLGRECLRGGGKNMDK-----YEKKSCKRLCKDCGYVPKRITTEVTSSCNC-KFHWCCSVKCSQCTKTVTKYICVQRESSK-NRRKNVRKKSKQRRRNRGNN*-- Capitella_teleta_wnt1 PLFINPSLQPLTR-KQRRLVTRNPG-TSIAIAKAARMAVDECQRQFSTRRWNCPVYDASHGS------------------------SIFG--KVVRK-GIRECAFIYAIMSAALAHSIARSCAEGSI-YTCTCGRH--------SRRLANS---------------------------------VQPRDWEWGGCS-DNAEFGRKFSHDFIDVAEK-------GRD----------------LKCLMNLHNSEAGRTQVSSEMSKECKCHGMSGSCTVKTCWMKLPMFG-RVGKVVKDRFD-GASQVEQ-GNG--AINRSKNR-----------------------------------------------------------------------------------------------------------FNLIPIN-----------TNHKPPEPKDLVYFERSPTFCTKDPSIGHTGTHGRPCNAS-----------SIGVEGCDLLCCGRGYRSE--LYTARERCNC-IFHWCCKVTCDTCTKTKVRHICL*----------------------------- Capitella_teleta_wnt10 TSSVCRTIPDLTG-PQYALCLKHPD-VMEVAVQGLKMAMEECQFQFREHRWNCTSMTKKHNSP-------------------------YG-NRLLHKG-YRETAFASAISAAGMSAQIALACAMGNL-PACGCN---P-------RMET------------------------------------STQQWVWKGCQ-HNVRFGDYFTRKFWGSKK-----EATNVYS------------------EMDVHNSRAGRMIWRENVRLHCKCHGMSGSCEVRTCWKAASSFR-KVGSIIKQKFE-QATKVDTDN----------------------------------------------------------------------------------------------------------------------SSKRSRRLKT-------ARRRKRHIDNTDLVYFERSPNFCEPDKTLDSPGTVGRVCNSSS-----------LHIDSCDTLCCGRGYNTV--RLTKIERCQC-KFRWCCDVLCKKCLMTSWVTVCK*----------------------------- Capitella_teleta_wnt11 ADCVKAKEHGLVK-QQIQICKRNME-LMPVVAHATRQTTDVCQYLFAQYRWNCTSVRMAPKYL-------------------------PD---LTGGS--REQAYVHALSAAALAQTISKACTQGAT-TKCSCGRI--------PNEAPPS-------------------------------------EFKWGGCG-DDLRFGMIFSASFAD---SPFLKRKKRSKQ-----------------AMMNLHNNNAGRKIISDSLVTDCKCHGVSGSCNIKTCWKALPDMR-TVGTKIQERYR-LAVEV-----------------------------------------------------------------------------------------------------------------------VNKKVKNSKERR-----FVPLMDKKTSFSENELIYYTKSPDYCLPDGGLGSMGTRGRECEKT----------ND-GSIGCQSMCCGRGFTSQ--VVEVKHRCEC-KYFYCCYVECKTCTKKVEINRCR*----------------------------- Capitella_teleta_wnt16 STHSCHILPGLVY-QQLRVCEENPH-TMPCVSYGARVGIEECHHQFKKERWNCTTPEDE----------------------ATGGINLFG---QILKRGTKETAFMYAVTSAGVVHAVTKACSSGNL-TDCTCDLSQQG------QTSGEG--------------------------------------WKWGGCS-DNVDYGMWFAETFVDAPEKL-----RHTASKDIRS-------------LMNLQNNAVGRQVINDQMNLKCRCHGVSGSCAVKTCWRTLTSFR-EAGNELKQKYE-NSISIAEKSKRKLRQ-----------------------------------------------------------------------------------------------------------------RQRRQRQR------------RTSNNGLDMVYIEDSPNYCRKNMKRGILGTKGRECERD-----------PDARDSCNTLCCGRGYNTE--VVRFVERCQC-KFVWCCEVKCKICETITDKQTCK*----------------------------- Capitella_teleta_wnt2 SGVICDNIPGLMS-RQRLLCRQHPD-VMMSVVFGAKKGVKQCQRQFRHHRWNCSVSHTDSS--------------------------VFG--KLMLKG-SKEAAFVYAISSAGVVHAITRACSQGRL-TNCACDPTK--------TGSSSD----------------------------------RNGKFDWGGCS-DNVRYGSHFARMFVDAREK-------RVKD---------------ARALMNLQNNRAGRRAVRRHMTLECKCHGVSGACTIRTCWLALQEFS-RVGSYLKTRYD-SAKQVSMNPMG----------------------------------------------------------------------------------------------------------------------TGLIATT---------SGGRKKTTRSDIVFFDESPDYCVQDPLAGSLGTADRECNHT-----------SKGPHGCDVMCCGRGYDTH--VVRRMRKCDC-KFHWCCYVKCRECEELVKVNTCRGPNPTAAPPISN--SIYARRTFT*------ Capitella_teleta_wnt4 KEEACDTLSGLVK-RQKKICKRNIE-VMHAVKKGAVSAIDECQYQFQNRRWNCSTVDHG-SAV-------------------------FG-NVLNAGT--REAAFVHAISSAGVTYAVTKACSSGQV-DKCGCDRS--------IRGKSPQ-------------------------------------GFEWAGCS-DNVAYGSAFCGMFVDARERA-KGRQSSRAL-------------------MNLHNNEAGRLAVEENMKVQCKCHGVSGSCEMKTCWRGLPSFR-EVGAMLKDRFD-GASEVE--------------------------------------------------------------------------------------------------------------------------EQKVGSRK----KLVPKNTQFKPHETQDLVYLEASPDYCISDPETGSLGTSGRTC-NR----------SSKAIDGCELMCCGRGFNVK--RRVVDERCHC-KFHWCCYVKCQQCKKVVDEYVCR*----------------------------- Capitella_teleta_wnt5 ---------------------------MPAVSAGAKIALGECQQQFHSRRWNCSLMEG-NGA-------------------------VFG--PVLDTG-SRESAFTYAIFAAGVVHAVSRSCRDGQL-TNCGCSRRM--------RPK------------------------------------TLHRDWLWGGCG-DNTDYGYRFAQGFVDIREREKNHPRHSPEL---------------ARTLMNLHNNEAGRRAVYSHTVVACKCHGVSGSCSLKTCWNQLAPFR-GTGNRIKDAYD-RGTEVAFNRQGT---------------------------------------------------------------------------------------------------------------------RLVQTN-----------KRFNKPTKEDLLYLAESPDYCEADPGIGSLGTQGRQCNKH-----------SQGMDGCNLMCCGRGYNTY--KAKVSERCQC-KFHWCCYVQCKTCERVVDINTCK*----------------------------- Capitella_teleta_wnt6 PNIICRKSRKLGG-KQHEMCRNEPE-IVEEVANGAKMAISECQHQFRHRRWNCTTANRS-----------------------------IQ--RVLKH-DTREAAFVHSLTSAGVLYAVTQACSLGLL-LQCMCDN----------SVMDR--------------------------------STDG--KWEWAGCN-EDVRFGSRKAAEFLDIPPT-------QRND---------------VQGRILLHNNKAGRASVAKYQQKICKCHGLSGSCELKTCVLKMPSFR-DVGDRLKERFD-GAYKVSIANDGR---------------------------------------------------------------------------------------------------------------------NIIPIED---------HDAARRPSGENLVYLDESPSFCKPSRKQGSLGTLDRLCNPD-----------TSTTDSCDIMCCGRGYRSY--KVVVQENCRC-QFKWCCKVICQTCSRTLSIHRCN*----------------------------- Capitella_teleta_wnt7 AHAICNRIPGLAP-RQRTICLSHPD-SMAAAGQGAKLAFEECSYQFRLHRWNCTITDNTAGRT-----------------------SPLA--AQHTIA-SKEAAYTSAIRSAGVSYIITQACSQGSI-MSCGCDKTK--------GDTSNA----------------------------------FSSEWKWGGCS-ADIKYGLTFSRLFLDSKE--------VKED---------------ERALMNLHNNRAGRKAVKSQMDTQCKCLGVSGACTIKTCWTTLPGFR-SIGDHLKQKFT-KAKQVVPLQSS---------------------------------------------------------------------------------------------------------------RTRNPEFLHLKR-L---------KSLHRKPRKADLVYLKRSPSYCEKDEGIGSLGTTGRLCNRT-----------ANSYNNCDLMCCGRGYNTH--QYTRTWQCDC-KFHWCCHVTCDECTELTEEYTCK*----------------------------- Capitella_teleta_wnt8 -------SLNNFLKAGSK----SYMALVDSVSSGTQLGLRECQEQFKWERWNCPLKQSVLRPFN---------------------------ARVQADTVTKEISFGQAITCAGVAHTITKNCSSGEF-ENCRCD--------ESKKGKKGGR------------------------------------TWKWGGCS-DNLRFGERVSKLFFDDRVAAT-----------------------DAMATVNLHNNEVGRTALKKTMELICKCHGVSGSCTTKTCWQHLSDFR-SVGTFLKRCYA-RAIDVDFQ-------------------------------------------------------------------------------------------------------------------------NGALQQTATRRHRRDRSE---LIRKTDLVYLQTSPDYCRVN---GSYATLGRQCVRSSAAAKSGRRNRHPERKSCHRLCKACGLKVTDKVVEVTSSCKC-KFKWCCEVACQQCRRKVELSTCTL*---------------------------- Capitella_teleta_wnt9 QAQQICLRLKLHP-AQKKMCLSSLG-ISSTLLDSVRLSVVECQANFKFDRWNCSLGK-------------------------------PR-INMLNKG-YKETAYLHALTSSSLVHTFSRACAQGRL-DRCTCDESFS-------ASKNK-------------------------------------EAWLWGGCG-DNIQYGMKFARRFLRWMRK----S-LDLQA------------------TADSHNSDVGIRVVRNGINKTCKCHGVSGSCTVQTCWRQLANFH-EVGSDLKSKYD-SAVKVVVSAN--------------------------------------------------------------------------------------------------------------------QSTGKGQLTKRR---KNSVQS---NPKKGDLVFLEKSPNYCEPTA--FGHGTTGRVCDLN---------------KNCDILCCGRGYNIH--TRIVDKPCHC-QVIWCCHVKCQRCSVREDIYTCK*----------------------------- Capitella_teleta_wntA ------------------------------------MGIDECQHQFRDRRWNCTTYNDTDV---------------------------FG--KVLDLK-TREKAYIYAVSSAGVMFAVTTACAKGEL-HICDCDEK--------VRSQDTKG------------------------------------GFIWGGCS-HNVAFGDRFTREFVDSNEN--------RFN---------------DEGLMNLWNNNAGRKAIRTSMKLLCKCHGVSGSCSAKICWKTMTGFR-NIGSQLKDKFD-GASRVIHHDK---------------------------------------------------------------------------------------------------------------------KHRLKPMD-----------RYQKKPNKKDLVYLQESPDFCSSNTTIGSLGTQGRACNKT-----------SYGLDGCSLMCCGRGYQT--------EDCNC-KF-WCCNVVCDECIKREERHICN------------------------------ Helobdella_robusta_wnt1 ---------------------------------------------MAYRRWNCSVVTPLAASSLLFGRS------------------LFG--KITNK-GRLETSYLQSLTSASLMHSIAQGCSSNMI-SGCTSKTG--------ETNATTTATTLS--------------------------ATTNDVEWRWDGCN-DNDIFGSEFTREFIDRGEK-------YRD----------------LKSGVLKHNSRAGRQHVLQNMQKECKCHGMSGTCSLKTCWMKMPSIS-LVAAILKEKFN-GATKVDQ-GNSHHEHEKRR---------------------------------------------------------------------------------------------------------------LLPHN-----------PEHKKPTKFDLVYYEDSPTFCDPDPSLGYPGVKGRKCIEN-----------SMGMDGCDVMCCGRGYKKV--TVREVQKCNC-SFVWCCDVTCDYCDVVEERFVCE*----------------------------- Helobdella_robusta_wnt10 --MLCRSIIGRLSPAHHYFCLRHHD-VTEVAILGLRIALSECRYQFKNELWDCTNVMYHRG---------------------------KQ-ISDPKKG-FKESSVIFALLGASVSTQISRACSAGDLQYSCGCTSAQSSHRPDHSKTHTQTDF-------------------------------WGKLRGYSQACQ-SSLTYGDVMGKKFMERRSLRGQ----------------------DILWHVQQHNENLGRKLVKKMAIVRCKCHGVSGSCQLKTCWKVAPDFR-RVADVIKTKFK-MAVRVDMKNNNNNNNINNNNNNKIN-------------------------------------------------------------------------------------------------NNNNNNNNNNNNNKQINFLMKNPHTNTPRNLRDSLIYTQNSPNFCNPEPKLKILGTTGRQCNAS-----------SLDDNDCGSICCGRGFDIV--VKTIVKKCLC-KFKWCCAVVCRKCFVRRWVAICK*----------------------------- Helobdella_robusta_wnt11a SSCNRRRTVGLTS-DQKDMCQKNLD-LMTSVVQAAKQTIDVCQEIFFEKRWNCSTILNAPKFL-------------------------PD---LTGGS--REQAFVYSLAAGSLAQTIAKACSSGLT-SKCGCAQI--------PTEPAPG-------------------------------------NFRWGGCG-DDVKFGVAFSRQFTD---QTESRRKKRSKD-----------------VLMNVHNAHVGRKMLADSIAPICKCHGVSGSCSVKTCFKSLPALK-VVAVMLQNRYS-AAVEMG------------------------------------------------------------------------------------------------------------------DNAAGISALQTTGSKK------SSRSLSKRVASTDRLVFSSISPDYCLPDPSLGSVGTQGRECDKD----------ST-GSSGCRSMCCGRGYVSE--IVVQTFKCNC-KYYWCCEVKCKVCRKLVEVHKCR*----------------------------- Helobdella_robusta_wnt11b SRITCPKSEKFLAKQQQEFCRQTQQ-HANLLAETSNDVVELCEQAFQFKRWNCSSVRLAP----------------------------RF-KRDLTKG-TREQSFVYSLSSSVFLLNLERYCHLGQIIEGCRCAKRWH------ESDDTRIFN-----------------------------------------AKSNDVERC--NSIRYV------------------------------GVEVQTRLHNTAVGRKIITKSLAKYCRCHGTSGSCNVKVCWMAFNMTRDRLLHVLVKKYY-QAIRVRGSKNINSIMIKHKNGN-----------------------------------------------------------------------------------------------------NNNNNNNNNNNGRMISSSQE--------SFSNNLIYSAISSDYCLPDKYLGSSGTYGRECHLE-----------PKKQGHCDVMCCGRGFRNE--TRSRGVKCHC-KYYWCCYVKCKTCVQDVLVHFCK*----------------------------- Helobdella_robusta_wnt11c WDCTNPNLEGLLD-YQKKICIKNLD-LMSGVVHASLQTAQTCQELFIDSRWNCSNILQAPRYM-------------------------PD---LTGGS--REQAVVYALASASLVQSIAKTCSSGYS-TKCSCGRH--------PFDEPPAT------------------------------------DFKWGGCG-DDVRFSVDFSHKFTDKFWQKKLKEKKLKKL-----------------AMINLHNNRVGRQIMSTSLGTSCKCHGVSGSCSVKTCWKSLPDLK-TIGALLVHQYA-IAVEVDLRRPRVKNDDVTVGGKRGGRSGDKQQQQMSNSFWLDHEEKWIDFDYGGEEALIMAMNNNNNNNNNNNQNGINNINANNNNNNHMNNDYNEYDYGVDVRVMKAKSAPPSPPSLSNKKNNKNNKNKNNKNKKDVKKVLVPILPFRKNFSENDLLFITKSPDYCLPEPSLGSIGTKGRECSRT----------ED-GSGGCKSMCCGRGFTSE--EVEIQYRCDC-KYYWCCYVKCKTCYKVVEINRCR*----------------------------- Helobdella_robusta_wnt16a TCQLLQQHGYISS-EQLSLCLGDHF-SVLAAVSGRRLGLSECFHQFRYERWNC---------------------------SATVARNIES---GGKQRRTKEQAFMQAVMSAGVVFTVTEACSSGKL-LRCSCLSIPSSS-----SSSSSSNNNNN---------------------------RFNDDTWKWGGCS-DDIDYGLSYAKLFTDKPIKKQLLKNGIFRMSDLKG-------------LVDLHNNEVGRQILSSLMKIKCRCHGVSGLCGVRTCWKSLPTFR-EVGDALKNKYE-TSIEISRPSQHLLK-------------------------------------------------------------------------------------------------------------------REKRRRR------------REPISSADLIFLKKSPDYCKQNLKKGIPGTRGRLCNKN-----------STGPDGCDYLCCGRGFNLA--ETRLVERCHC-KFIWCCSVQCKMCERVEIKYTCK------------------------------ Helobdella_robusta_wnt16b MVELPLRH------PQLFKAIG--------------------VKQFEEERWNCRLLD-----------------------GATKDENILE---TILQQGTKEIAFIHAITSASLAHSITSSCSAGLL-LECSCDRSLQSI-----VSTDSS--------------------------------------WRWGGCS-DNVQYGIKYSKIITDGGKKQKDGKKAAL-MERVRS-------------LVHLHNNDVGRKTLHSLMTHKCRCHGVSGSCAVRSCWRSLPSFR-QVGDQLKFKYL-DSVEIS-PSLQLADSNSVSVA---------------------------------------------------------------------------------------------------------SGQKSQWRSI------------PQPASDTDLIFLDKSPNYCRPDRKRGVQGTRDRNCQPD-----------TDKPNNCKHLCCGRGYRTR--VIEVDEACEC-QFMWCCSIQCKICKKVQVVHTCL*----------------------------- Helobdella_robusta_wnt2 RLCYRHQQPYLSK-KQRETCYTRLD-LMRAVIHGLKMSIKECKRLFKYRRWNCTTFANGPH--------------------------VFG--KMELSG-HRESAFLQALTTASVVHTVHKRCYSGKI-KNCNCGSGG--------NSDAIRKR-------------------------------FVTSSFKWSGCR-DELAFGEKFARDFIDDENEV-----GPKSG----------------LDLMRMRNNAAGRRAVRKSLRLNCTCYGASGSCTVRTCWNSTAEFS-EIAEFLMSKYN-SAKHVYIDTNNLISHY---------------------------------------------------------------------------------------------------HTSLSRIKRNKKPKPFKLSMI---------DRKLKRPAKDDLVYVDFSPDYCQTNHELGRQ--EYK---HI*----------------------------------------------------------------------------------------------- Helobdella_robusta_wnt4 --EDCQFLVGFTK-EQQQICGRSLE-LMNYVLEGVVESIQACRAEFEGERWNCSGGLES--VN-------------------------SGGRVVEAGT--RETAFLYAILSAGVTHKVTKACSSGRL-KNCGCDRT--------LTG-----------------------------------------QEEWSGCS-DNVAYGKAFARSLIDVREELVGMSHPSRAL-------------------LNLHNNNAGRKTVELSMRTHCRCHGVSGACEMKTCWKTLPPFD-DVSKRLKINYD-NSKMVK--------------------------------------------------------------------------------------------------------------------------LKKAGSQM----DFAPQQQQPHSFNETDLLFTHASPSYCDLDLSRGSLGTSGRLCSND----------KTATTDSCKVLCCGRGYVVVG-EVTLVEKCHC-KFHWCCRVECQECKRRVELYRCK*----------------------------- Helobdella_robusta_wnt5a ------------------------------------MAADECFQQFGGMRWNCSLLSRGNKS------------------------SFMTLPDYLPDG-CKEASILKAFFSASMTFNVARACKDGQL-PQCGCSRRE--------KPR------------------------------------HLPAEWVWGGCG-DNTEYGFKFGVGFVDSREREMNYPRYSHEL---------------KIMLSNLHNNMVGRRTVVGLSKASCRCHGASGSCSMKTCWHQMADFN-EIARELKFKYENLPHLVKFNNAGTNSDYENIDNDDN-------------------------------------------------------------------------------------------------------TQQQPATD-----------TSSNRPTRDTLIYTEPSPDFCEALTNTSWPGTHGRQCKRG-----------EPGSEGCDLMCCGRGYNTF--REKVTERCRC-HFVWCCSVHCSTCEKYIDVHVCK*----------------------------- Helobdella_robusta_wnt5b MTFSCNTMNVLSY-GQMKFCQLYED-HMIGVVKAAQMGIGECQHQFKDRRWNCTVMPK-EPS-------------------------VFG--KVATRA-TRESAFLHAMMSAGVVHSISRMCRDGEL-TGCGCSKKK--------RPKK-----------------------------------AIRPEWIWGGCG-DNTDYGYKFSGGFVDVMEKEKNHPRKSPGL---------------SRMLMNLHNNEVGRRAVYRHVKIGCKCHGTSGSCSVRTCWNQLPSFR-QTGDRLRDRYD-AAAQVTFNPQGT---------------------------------------------------------------------------------------------------------------------RLIPIN-----------RKFNRPTKDDLIFTEPSPNFCNPDPERGSLGTSGRVCDRR-----------SQGTSGCGLMCCDRGYRSS--KVKYVERCKC-KFHWCCNVSCQTCERSMHVHTCN*----------------------------- Helobdella_robusta_wnt6 ---------MKTD--------------------------------------------------------------------------------------SREAALIRALTSAGILLKIFEACSRGQL-SQCGCEKTIS-------------------------------------------------RPQIWRSCA-GVVSFAAKIAQTFTESSDFG------SGRD---------------FKSILHRHNHRVGRLLSTSPTRQHCKCHGLSGSCTIFTCWQKLPTFA-TVGKKLRKVYEKAVQVTASNDHHQ------------------------------------------------------------------------------------------------------------------------------------DGESMLMTMRRSLVYSVKNLDFCTRNVKKGIEGTQGRICNPP-----------VTKIGSCEYLCCGRGFEKR--REIIEEECRC-TFKWCCTVVCSICKRTIEVFRCL*----------------------------- Helobdella_robusta_wnt7 ASVLCNKVPGLVP-EQRRLCRAYPE-AMAVVGEGAELGIEECRQQFSSRRWNCSSSENEP---------------------------PLM--FMTNIA-SKESAFVSAARSAGIAYAITRACSRSDL-AGCACDKSV--------SK----------------------------------------SDWEWNGCS-ANVNYGIKFCENFLDAREK-------YSDN---------------SQSLMNLHNNRAGRKVLRSSMKRNCKCSGVSGSCSVKTCWTSLPLMK-TIGSKLMKTYE-RARQVEAIRGQ---------------------------------------------------------------------------------------------------------------RSLSAVMLKLKRSA---------SKTEKKPSYRELVYLAESPDYCKKNRTIGVLGTKGRQCDRN-----------GDGLENCRHVCCGRGYNNQ--VVTKRKKCDC-VFHWCCHVTCKECMELTEESSCR*----------------------------- Homo_sapiens_wnt1 QLVLEPSLQLLSR-KQRRLIRQNPG-ILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPH---------------------------LFG--KIVNR-GCRETAFIFAITSAGVTHSVARSCSEGSI-ESCTCDYR--------RRGPG-------------------------------------GPDWHWGGCS-DNIDFGRLFGREFVDSGEK-------GRD----------------LRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLR-AVGDVLRDRFD-GASRVLY-GNRGSNRASRAEL-----------------------------------------------------------------------------------------------------------LRLEPED-----------PAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSS-----------SPALDGCELLCCGRGHRTR--TQRVTERCNC-TFHWCCHVSCRNCTHTRVLHECL*----------------------------- Homo_sapiens_wnt10a ANTVCLTLPGLSR-RQMEVCVRHPD-VAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIP-------------------------YE-SPIFSRG-FRESAFAYAIAAAGVVHAVSNACALGKL-KACGCDASRR-------GDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCS-PDMGFGERFSKDFLDSRE-----PHRDIHA------------------RMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFR-TVGALLRSRFH-RATLIRPHNR--------------------------------------------------------------------------------------------------------------------NGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSS-----------AGSDGCGSMCCGRGHNIL--RQTRSERCHC-RFHWCCFVVCEECRITEWVSVCK*----------------------------- Homo_sapiens_wnt10b ANTVCLTLSGLSK-RQLGLCLRNPD-VTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLP-------------------------HH-SAILKRG-FRESAFSFSMLAAGVMHAVATACSLGKL-VSCGCGWKGS-------GEQDRLRAKL--LQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCN-HDMDFGEKFSRDFLDSRE-----APRDIQA------------------RMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFR-AVGAALRERLG-RAIFIDTHNR--------------------------------------------------------------------------------------------------------------------NSGAFQPRLR-----------PRRLSG--ELVYFEKSPDFCERDPTMGSPGTRGRACNKTS-----------RLLDGCGSLCCGRGHNVL--RQTRVERCHC-RFHWCCYVLCDECKVTEWVNVCK*----------------------------- Homo_sapiens_wnt11 QTQHCKQLEGLVS-AQVQLCRSNLE-LMHTVVHAAREVMKACRRAFADMRWNCSSIELAPNYL-------------------------LD---LERGT--RESAFVYALSAAAISHAIARACTSGDL-PGCSCGPV--------PGEPPGP-------------------------------------GNRWGGCA-DNLSYGLLMGAKFSDAPMKVKKTGSQANKL-------------------MRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELQ-DVAADLKTRYL-SATKVV--------------------------------------------------------------------------------------------------------------------------HRPMGTRK----HLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCNKT----------SN-GSDSCDLMCCGRGYNPY--TDRVVERCHC-KYHWCCYVTCRRCERTVERYVCK*----------------------------- Homo_sapiens_wnt16 PEKLGCANLPLNS-RQKELCKRKPY-LLPSIREGARLGIQECGSQFRHERWNCMITAAATTAP-------------------MGASPLFG---YELSSGTKETAFIYAVMAAGLVHSVTRSCSAGNM-TECSCDTTLQNG-----GSASEG--------------------------------------WHWGGCS-DDVQYGMWFSRKFLDFPIGN-----TTGKENKVLL-------------AMNLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMSSFEK-IGHLLKDKYE-NSIQISDKTKRKMRR-----------------------------------------------------------------------------------------------------------------REKDQRKI------------PIHKD--DLLYVNKSPNYCVEDKKLGIPGTQGRECNRT-----------SEGADGCNLLCCGRGYNTH--VVRHVERCEC-KFIWCCYVRCRRCESMTDVHTCK*----------------------------- Homo_sapiens_wnt2a SRVMCDNVPGLVS-SQRQLCHRHPD-VMRAISQGVAEWTAECQHQFRQHRWNCNTLDRDHS--------------------------LFG--RVLLRS-SRESAFVYAISSAGVVFAITRACSQGEV-KSCSCDPKK--------MGSAKD----------------------------------SKGIFDWGGCS-DNIDYGIKFARAFVDAKER-------KGKD---------------ARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFR-KTGDYLWRKYN-GAIQVVMNQDG----------------------------------------------------------------------------------------------------------------------TGFTVAN---------ER-FKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLT-----------SRGMDSCEVMCCGRGYDTS--HVTRMTKCGC-KFHWCCAVRCQDCLEALDVHTCKAPKNADWTTAT*------------------ Homo_sapiens_wnt2b ARVICDNIPGLVS-RQRQLCQRYPD-IMRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHT--------------------------VFG--RVMLRS-SREAAFVYAISSAGVVHAITRACSQGEL-SVCSCDPYT--------RGRHHD----------------------------------QRGDFDWGGCS-DNIHYGVRFAKAFVDAKEK-------RLKD---------------ARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFR-RTGDYLRRRYD-GAVQVMATQDG----------------------------------------------------------------------------------------------------------------------ANFTAAR---------QG-YRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKT-----------SKGTDGCEIMCCGRGYDTT--RVTRVTQCEC-KFHWCCAVRCKECRNTVDVHTCKAPKKAEWLDQT*------------------ Homo_sapiens_wnt3 QPLLCGSIPGLVP-KQLRFCRNYIE-IMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSL--------------------------AIFG--PVLDK-ATRESAFVHAIASAGVAFAVTRSCAEGTS-TICGCDSH--------HKGPPG-------------------------------------EGWKWGGCS-EDADFGVLVSREFADARE--------NRPD---------------ARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFR-AIGDFLKDKYD-SASEMVVEKHRESRGWV---------------------------------------------------------------------------------------------------------------ETLRAKY-----------SLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVT-----------SHGIDGCDLLCCGRGHNTR--TEKRKEKCHC-IFHWCCYVSCQECIRIYDVHTCK*----------------------------- Homo_sapiens_wnt3a QPILCASIPGLVP-KQLRFCRNYVE-IMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSL--------------------------AIFG--PVLDK-ATRESAFVHAIASAGVAFAVTRSCAEGTA-AICGCSSR--------HQGSPG-------------------------------------KGWKWGGCS-EDIEFGGMVSREFADARE--------NRPD---------------ARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFR-AIGDFLKDKYD-SASEMVVEKHRESRGWV---------------------------------------------------------------------------------------------------------------ETLRPRY-----------TYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVS-----------SHGIDGCDLLCCGRGHNAR--AERRREKCRC-VFHWCCYVSCQECTRVYDVHTCK*----------------------------- Homo_sapiens_wnt4 EEETCEKLKGLIQ-RQVQMCKRNLE-VMDSVRRGAQLAIEECQYQFRNRRWNCSTLDS--LPV-------------------------FG-KVVTQGT--REAAFVYAISSAGVAFAVTRACSSGEL-EKCGCDRT--------VHGVSPQ-------------------------------------GFQWSGCS-DNIAYGVAFSQSFVDVRERS-KGASSSRAL-------------------MNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPPFR-QVGHALKEKFD-GATEVE--------------------------------------------------------------------------------------------------------------------------PRRVGSSR----ALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTC-NK----------TSKAIDGCELLCCGRGFHTA--QVELAERCSC-KFHWCCFVKCRQCQRLVELHTCR*----------------------------- Homo_sapiens_wnt5a AQPLCSQLAGLSQ-GQKKLCHLYQD-HMQYIGEGAKTGIKECQYQFRHRRWNCSTVD--NTS-------------------------VFG--RVMQIG-SRETAFTYAVSAAGVVNAMSRACREGEL-STCGCSRAA--------RPK------------------------------------DLPRDWLWGGCG-DNIDYGYRFAKEFVDARERERIHAKGSYES---------------ARILMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFR-KVGDALKEKYD-SAAAMRLNSRG----------------------------------------------------------------------------------------------------------------------KLVQVN-----------SRFNSPTTQDLVYIDPSPDYCVRNESTGSLGTQGRLCNKT-----------SEGMDGCELMCCGRGYDQF--KTVQTERCHC-KFHWCCYVKCKKCTEIVDQFVCK*----------------------------- Homo_sapiens_wnt5b AQPVCSQLPGLSP-GQRKLCQLYQE-HMAYIGEGAKTGIKECQHQFRQRRWNCSTAD--NAS-------------------------VFG--RVMQIG-SRETAFTHAVSAAGVVNAISRACREGEL-STCGCSRTA--------RPK------------------------------------DLPRDWLWGGCG-DNVEYGYRFAKEFVDAREREKNFAKGSEEQ---------------GRVLMNLQNNEAGRRAVYKMADVACKCHGVSGSCSLKTCWLQLAEFR-KVGDRLKEKYD-SAAAMRVTRKG----------------------------------------------------------------------------------------------------------------------RLELVN-----------SRFTQPTPEDLVYVDPSPDYCLRNESTGSLGTQGRLCNKT-----------SEGMDGCELMCCGRGYNQF--KSVQVERCHC-KFHWCCFVRCKKCTEIVDQYICK*----------------------------- Homo_sapiens_wnt6 PTSICRKARRLAG-RQAELCQAEPE-VVAELARGARLGVRECQFQFRFRRWNCSSHSKA-----------------------------FG--RILQQ-DIRETAFVFAITAAGASHAVTQACSMGEL-LQCGCQAPRGRAPPRPSGLPGTPGPPGP------------------------AGSPEGSAAWEWGGCG-DDVDFGDEKSRLFMDARHK------RGRGD---------------IRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFR-EVGARLLERFH-GASRVMGTNDGK---------------------------------------------------------------------------------------------------------------------ALLPAV-----------RTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSS-----------APDLSGCDLLCCGRGHRQE--SVQLEENCLC-RFHWCCVVQCHRCRVRKELSLCL*----------------------------- Homo_sapiens_wnt7a ASIICNKIPGLAP-RQRAICQSRPD-AIIVIGEGSQMGLDECQFQFRNGRWNCSALGERT---------------------------VFG--KELKVG-SREAAFTYAIIAAGVAHAITAACTQGNL-SDCGCDKEK--------QG-QYH----------------------------------RDEGWKWGGCS-ADIRYGIGFAKVFVDARE--------IKQN---------------ARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFR-ELGYVLKDKYN-EAVHVEPVRAS---------------------------------------------------------------------------------------------------------------RNKRPTFLKIKK-P---------LS-YRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKT-----------APQASGCDLMCCGRGYNTH--QYARVWQCNC-KFHWCCYVKCNTCSERTEMYTCK*----------------------------- Homo_sapiens_wnt7b ANIICNKIPGLAP-RQRAICQSRPD-AIIVIGEGAQMGINECQYQFRFGRWNCSALGEKT---------------------------VFG--QELRVG-SREAAFTYAITAAGVAHAVTAACSQGNL-SNCGCDREK--------QG-YYN----------------------------------QAEGWKWGGCS-ADVRYGIDFSRRFVDARE--------IKKN---------------ARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFR-EVGHLLKEKYN-AAVQVEVVRAS---------------------------------------------------------------------------------------------------------------RLRQPTFLRIKQ-L---------RS-YQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRT-----------SPGADGCDTMCCGRGYNTH--QYTKVWQCNC-KFHWCCFVKCNTCSERTEVFTCK*----------------------------- Homo_sapiens_wnt8a AFSASAWSVNNFLITGPK----AYLTYTTSVALGAQSGIEECKFQFAWERWNCPENALQLSTHN------------------------------RLRSATRETSFIHAISSAGVMYIITKNCSMGDF-ENCGCD--------GSNNGKTGGH------------------------------------GWIWGGCS-DNVEFGERISKLFVDSLEKGK-----------------------DARALMNLHNNRAGRLAVRATMKRTCKCHGISGSCSIQTCWLQLAEFR-EMGDYLKAKYD-QALKIEMD-------------------------------------------------------------------------------------------------------------------------KRQLRAGNSAEGHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNS-HNTSR-----WERRSCGRLCTECGLQVEERKTEVISSCNC-KFQWCCTVKCDQCRHVVSKYYCARSP----GSAQSLGKGSA*----------- Homo_sapiens_wnt8b LQLSHSWSVNNFLMTGPK----AYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHG------------------------------GLRSANRETAFVHAISSAGVMYTLTRNCSLGDF-DNCGCD--------DSRNGQLGGQ------------------------------------GWLWGGCS-DNVGFGEAISKQFVDALETGQ-----------------------DARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFR-EVGAHLKEKYH-AALKVDLL-------------------------------------------------------------------------------------------------------------------------QG---AGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRG-RALGR-----WERRSCRRLCGDCGLAVEERRAETVSSCNC-KFHWCCAVRCEQCRRRVTKYFCSRAERPRGGAAHKPGRKP*------------ Homo_sapiens_wnt9a AHYKACDRLKLER-KQRRMCRRDPG-VAETLVEAVSMSALECQFQFRFERWNCTLEGR------------------------------YR-ASLLKRG-FKETAFLYAISSAGLTHALAKACSAGRM-ERCTCDEAP--------DLENR-------------------------------------EAWQWGGCG-DNLKYSSKFVKEFLG-RRS----S-KDLRA------------------RVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFH-EVGKHLKHKYE-TALKVGSTTN--------------------------------------------------------------------------------------------------------------------EAAGEAGAISPPRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGR--FSPGTAGRRCHRE---------------KNCESICCGRGHNTQ--SRVVTRPCQC-QVRWCCYVECRQCTQREEVYTCKG*---------------------------- Homo_sapiens_wnt9b AHLKQCDLLKLSR-RQKQLCRREPG-LAETLRDAAHLGLLECQFQFRHERWNCSLEG--------------------------------R-MGLLKRG-FKETAFLYAVSSAALTHTLARACSAGRM-ERCTCDDSP--------GLESR-------------------------------------QAWQWGVCG-DNLKYSTKFLSNFLGSKRG----N-KDLRA------------------RADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFR-ETGQVLKLRYD-SAVKVSSATN--------------------------------------------------------------------------------------------------------------------EALGRLELWAPAR---QGSLTKGLAPRSGDLVYMEDSPSFCRPSK--YSPGTAGRVCSRE---------------ASCSSLCCGRGYDTQ--SRLVAFSCHC-QVQWCCYVECQQCVQEELVYTCKH*---------------------------- Lottia_gigantea_wnt1 QLYNNPSLLPLTK-KQKKLVTRNPG-SIMAIAKGAKMAIDECKYQFKNRRWNCPTYVDGHGG------------------------SIFG--KILNT-GCRETAFIYAATSAAVSHSIARACSEGSI-HTCSCDFE--------HNKVP------------------------------------VGKDWEWSGCS-DNARYGHKFSRRFVDVLEK-------GRD----------------FRYMMNLHNNEAGRVHVSSGMKQECKCHGMSGSCTIKTCWMRLPPFR-NIGHILKDRFD-GASKVLP-GNTGRAVKRKRRR-----------------------------------------------------------------------------------------------------------FNFSPVN-----------PNHKRPGRRDLVYFEHSPTFCEKENMIGFEGTAGRECNST-----------SLGVNGCDLMCCGRGYKSE--TFPVKERCHC-TFHWCCQVKCQVCTRLKVRNTCL*----------------------------- Lottia_gigantea_wnt10 PNTVCKTYPDLSE-AQYDLCRKYPD-VTASAIQGVQVAIHECQFQLAEYRWNCSSLERKNKNP-------------------------HS-SPLLSKG-YKETSFAYAISSAGVTHQVSKACSMGKL-KSCGCDMSVY-------GNQQ---------------------------------------NFEWGGCS-HNINFGAKYASKFLDSKER----TSRDIHA------------------QINLHNNRAGRLAIIRHVRKQCKCHGMSGSCELKTCWKAAPDFR-AVGTILKKKYD-RATKVQVDIT--------------------------------------------------------------------------------------------------------------------NSANTKLIKRN-----------GRIPKHLELLFYEKSPNFCDPNPLVDSPGTTGRLCNKTS-----------GGINNCETLCCGRGYNTL--RVKRTERCHC-KFFWCCYVTCKTCEYDEWVTVCK------------------------------ Lottia_gigantea_wnt11 --CS--KALGLLP-RQRRICKQHLE-IMSTIVGASLLSVETCQNQFSDRRWNCSSISQVPSVP-------------------------RD---LSRGT--REQAYVYGIASAALTHSVARACSIGVT-RKCSCGAL--------PNTAPTG-------------------------------------AFKWGGCG-DDLHFGMALGRAFTDASLKSKKGKSKSSKK-----------------AMMNRHNFAAGRKIVESSLTTACKCHGVSGSCSIKTCWKSLPDFD-SIGATLKNRYA-LAVEVK--------------------------------------------------------------------------------------------------------------------------RKRKKKQK----VLVPIMKNKKTIRSDELIYYTKSPDYCSPDAKSGSIGTHNRLCDKT----------SR-GSGGCDVMCCGRGYDSF--KMEVMERCEC-KYYWCCYVKCKTCVKTLNLSKCR------------------------------ Lottia_gigantea_wnt16 -------IPGLVI-QQKEVCQKNPE-SVYCIGEGARRGILECQKQFKFERWNCT---------------------------LIGNNTVFG---HVLSKGTREAAFIYAILSAGVVHSVTQSCSAGNL-TDCSCDMSKYGR-----ENKGEG--------------------------------------FQWGGCS-DNVDYGLKFSRGFVDAPEIV-----RHEDSRDIRN-------------LMNLHNNEVGRQIVEKNMQLRCRCHGVSGSCAVRTCFRSLPNFR-KVGLELKDKYE-KSVRLARRSRKRLRR-----------------------------------------------------------------------------------------------------------------KDKTKRKQ------------GISKQ--ELVFVHRSPNYCKEDIKRGIFGTRGRVCNRS-----------SPTEESCDLLCCGRGYNTQ--VVKYVERCHC-KFFWCCYVKCKTCETMMDIHTCK------------------------------ Lottia_gigantea_wnt2 TGVLCDNIPGLVG-KQRKMCRHYPD-VMVWLREGARLGVEECQYQFQDHRWNCSTLHRDAS--------------------------VFG--KSMLKG-TREAAFVYSISSAGVVYSITSACSKGEL-LHCACDPTK--------RGTSKD----------------------------------SKGEFDWGGCS-DSVRFGSRFSRMFVDAKEK-------RVSD---------------ARALMNLHNNRAGRRAVRRFRKLMCKCHGISGSCTLRTCWLAMEDFR-RVGDFLKRKYN-GATQIMMNQAG----------------------------------------------------------------------------------------------------------------------TGLIVAN---------KN-HKHPTRSDLVYFESSPDYCIKDEESGSLGTEGRECIKG-----------SLGTGGCDIMCCGRGYDTK--TIVKQEQCEC-KFHWCCLVKCKECSKTMDVQTCKGPISSSASSLLSSSSLSSLQTVQRVLNKP* Lottia_gigantea_wnt4 DENHCDSLYGFVK-RQKKLCRKNLE-IMDNVKVGARVAIEECQSQFGNRRWNCSTANS--KKL-------------------------FGNVILKQGT--REAAFVHAISSAGVAHSVTRACSSGTL-QKCGCDRT--------VRGRSPE-------------------------------------GFEWSGCS-DNIDYGMAFSKAFVDAREKGKKRKNTGRAL-------------------MNLHNNEAGRKAVDANMKVECKCHGVSGSCEMRTCWKAMPSFK-KVGEILKEKFD-GATEVK--------------------------------------------------------------------------------------------------------------------------HQVKGTRN----ELVPLNPQFKRHTESDLVYMVASPDFCEADKKTGSLGTHGRIC-NK----------TSKAIDGCELLCCGRGYRTR--IVTIKERCFC-KFLWCCYVKCKECTRQIEEHTCL------------------------------ Lottia_gigantea_wnt5 AQPMCTELQGLSP-GQIRFCRVYHD-HMPSIGRGAQLGIHECQYQFRNRRWNCSTVD--DSS-------------------------VFG--PVLNIG-NREAGFTHSISAAGVVYAISRACREGEL-SKCGCSRAR--------RPK------------------------------------DLHRDWIWGGCG-DNIEYGYKFAKAFVDMREKEKNHPRHSRDL---------------SRMLMNVHNNEAGRRAVYNFAKVACKCHGVSGSCSLKTCWQHLPNFR-EIGNRLKDRYD-ASTEVKFNKRGT---------------------------------------------------------------------------------------------------------------------KLTRKV-----------KKWNKYTKNDIIFLDDSPDYCDKNAETGSVGTAGRECDRN-----------SQGLGGCGLLCCGRGYNTF--KRKLIERCNC-KFHWCCFVRCGSCERYVDVHICR*----------------------------- Lottia_gigantea_wnt6 TNSICRKTRRLAG-KQRAICRKEPE-IVEEVAKGAKVALMECQYQFRTRKWNCTTLRRS-----------------------------LS--KILRR-DTREAAFVYAITAAGVVYAVTEACSMGRL-LQCTCDN----------NLRDI--------------------------------ATDG--EWEWGGCG-DNVDFGYQKSREFMDARRRK-----RRRGD---------------VTTLVQLHNNEAGRQAVRKYMRKECKCHGLSGSCTLKTCWRKMPLFR-DVGNRLKQKFD-GGSKVISSNDGK---------------------------------------------------------------------------------------------------------------------YLIPEG-----------DTIKPPSKEDLVYSEESPDFCRRNKKEGALGTRGRECDPT-----------SMGVGGCDLLCCGRNYSKK--QVTIKENCNC-RFMWCCEVICETCQKIKTETRCL*----------------------------- Lottia_gigantea_wnt7 ANIICNKIPGMAP-KQRAICRSRPD-AIVSIGEGAKLGLTECQYQFRFMRWNCSTLDSND--------------------------SMFG--YESLGG-TKEAAFIYAMTSAGVSYAITQSCGLGSL-PNCGCDKDK--------GD-GKL----------------------------------APQGWKWGGCS-ADIKHGLRLARKFMDARE--------IAQN---------------ARSLMNLHNNRAGRKAVKDNMGTDCKCHGVSGSCTMKTCWTTLPPFR-KIGDSLKKRYK-KSKIVVPYLGR---------------------------------------------------------------------------------------------------------------RARTAVTLILKR-A---------KRPHRKPRRSHLVYLDKSPNYCDFDGKTGSLGTVGRKCNRT-----------TKDTDGCDLMCCGRGYNTH--QYTRTWQCNC-KFHWCCYVNCNKCSERTEEYTCK*----------------------------- Lottia_gigantea_wnt9 SSAKLCEMLKLHR-RQKRMCRRGKG-IAESLLEATRLAVIECQYQFKHERWNCSLGQ-------------------------------YR-QNILRRG-FSETSFLYAISSAGLVHAFARACSKGVL-DRCTCDESK--------HLENH-------------------------------------KTWLWGGCG-DNLRYGLKFTRKFLKRARK----SGKDVRA------------------KVNQHNSRVGIKVVKENVNTTCKCHGVSGSCTVKTCWLQLSPFS-KIGRTLKNKYE-RAKKVLIQTN--------------------------------------------------------------------------------------------------------------------QATGKNLLVRRANAETNALNNEGRSPKRGNLLYMDESPSFCRRSR--YTPGTTGRTCDKD---------------RDCETMCCGRGYNVK--HTTVVKACKC-QVFWCCHVKCKQCLKNQEIYMCK*----------------------------- Lottia_gigantea_wntA -RKRCSNLAFLAP-RQQELCGLEEK-IIDVIHDGASMGIDECQHQFRDRRWNCTTFNTTNV---------------------------FG--QILKIK-SRETGYIYAILSAGIMYSVTRACAKGDL-DHCGCDTK--------VRRISTEG------------------------------------EFEWGGCS-DNIRYGSKFSKDFVDSKEM--------RIS---------------EDGLMNVWNNGAGRKMVKDELELMCKCHGVSGSCSVKICWRKMKSFR-AIGSALKGRFD-GASLVKMDRR---------------------------------------------------------------------------------------------------------------------RKRLKRTN-----------KLQKRPTKKDLVYLNESPDFCEHNLENGSVGTRGRECNKT-----------SYGLDGCRLMCCGRGYYT--------DDCDC-KF-WCCRVECKKCTNVKEMHYCN------------------------------ Nematostella_vectensis_wnt1 QLSPPNQIRALTQ-KQIRISRRYPE-LIQYIAGGARTAIHECQHQFRNRKWNCSAHSPEN---------------------------VFG--KILKR-ACRETAFTYAITAAGVSHAIARACGEGKL-SACSCDQR--------YRGVS-------------------------------------KQGWQWGGCS-DNIHFADNFSKRFVDAQEK-------GRD----------------FRAQINLHNNEAGRAAVRNNMMLECKCHGLSEACTVKTCWKRLPDFR-LVGDDLKAKFD-DASMVEYQQNNNNRNSNRNRNEDP--------------------------------------------------------------------------------------------------------ALFIPSK-----------PYLRRPTVYDLGYYEHSPNFCERNPSAGSLGTQGRECNTT-----------SMGTDGCELMCCGRGFTTS--SQERVENCNCRVFLGGCEVKCQKCKHEGSLSNCL*----------------------------- Nematostella_vectensis_wnt10 SNTVCKNTPSLSK-EQLKMCRRLPD-VVASALQGMQYAIHECLAQFRYRRWNCSSLEMKNRNP-------------------------LA-NPLLSRG-FRETAFVHAILSAGMTSSVARACSMGKL-AKCGCDESLR-------GRGT---------------------------------------GWEWGGCG-DNIDYGIETSAKFLDSRE-----KGRDLHS------------------MMNMHNNMVGRTTLSENAKTKCKCHGMCGSCSVKTCWKTVPDIR-EIGDRLMEKYD-HATTIGMGN-----------------------------------------------------------------------------------------------------------------------GRLRLHLTRR--------KARRSSVGRALVYYEDSPNYCIENKELGIFGTRGRICSPES-----------LDTDNCQNLCCERGYTTK--KLQVTKRCRC-HFSWWCYLICDTCRETSTVSICS*----------------------------- Nematostella_vectensis_wnt11 DKKDCNRIHGFSG-KQYKICRRNLP-AMLYVTAAVEMTREECQHQFQNKRWNCSTIVKAPQFL-------------------------PD---LKRGT--PEAAFVYALSAAALTYSITQACGMKRL-KPCKCGTN--------PKFKHPD--------------------------------------GEWGGCH-DNIARGMRFSKDFTDAVEAQRMRKHKSMAV-----------------ALMNLHNNGVGRKAVHSRLEFHCRCHGVSGGCTAKTCIRRLGDFR-LVADLLKNRYA-RIVYVES--------------------------------------------------------------------------------------------------------------------------KTKSKRK---ARVLKSKRGRRRYTSSDLVALQGSPNYCHKNRKRGTAGTHGRLCDPT----------KRRGEGSCAYLCCGRGHRTE--EVVHEERCEC-KYIWCCYVKCQTCRKRVRESRCL*----------------------------- Nematostella_vectensis_wnt16 VSPSCSRVPGLSL-QQLRMCLQKPD-VIPSVSQGANIGIHECKKQFKYERWNCSTS---------------------------NDPTVFG---TLLKIAHKESAFVYAITSAGVVHAVGKSCSKGNL-TECSCE-SKRGA-----RNQPKG--------------------------------------WEWGGCS-DNVNYGVWLSKTFVDAPEKADR---RARSQRKARA-------------MMNLHNNEAGREAVLALMRVQCRCHGVSSSCAVKTCSKSLPKFE-EVGEALKAEYK-DAIR-AVYIKRKRKL-----------------------------------------------------------------------------------------------------------------KRKDNKKL------------RIPSS--SLVYLDESPNYCYRDKKLGIDGTSGRECNKN-----------SSGVDGCDLLCCGSGYNTQ--TVRSVHSCHC-RFIWC*----------------------------------------------- Nematostella_vectensis_wnt2 AKVMCNSITGLIS-IQRQMCLDNPD-VMVSIGKGAKLGVEECQHQFRDQRWNCSTVNGDAT--------------------------VFG--KVMRRA-SRETAFVYAISSAGVVHEVTRSCSLGEL-KDCSCR-NK--------KGRSRK-------------------------------------GFEWGGCS-DNIQYGLNFAKAFVDSRE--------VEKD---------------ARALMNLHNNHVGRRVVKTNMSLDCKCHGVSGSCSVRTCWKSISSFR-IVGQHLREKYT-TAVQVTVGQSG----------------------------------------------------------------------------------------------------------------------GELTNAE---------VS-YKKPSRDDLVYLEDSPNYCMVDSNTGSLGTSGRECNGSA----------SDTTGACSLLCCGRGFNTI--QIEEEYKCHC-KFHWCCYVKCQTCRRTVDKHICKAPSQPE------------------------ Nematostella_vectensis_wnt3 KSMLCYVTRQFNS-RQQEVCRKNPD-LMEHVAHGAKYGVHECRHQFRNRRWNCSTIRESG--------------------------SLFE--SVLS-KGCREAAFVHAVTAAGVAHSVTDACSKGRI-ESCDCDRN--------LSGRSS-------------------------------------KGWTWSGCN-SNIKFGVWFSKQFTEARE--------RGDD---------------LRQIMNRHNSRAGRKALEELVWRKYKCHGLSGSCSMKTCWMQQANFR-QIGDHLKVKYD-SAVEMTTKVNRRGK------------------------------------------------------------------------------------------------------------------KRLKPKY-----------SHFKKPSDKDLIYFETSPNYCDKNVTVGSLGTSGRQCNYT-----------SNGIDGCELLCCGRGHNIQ--QAKITRNCNC-VFKWCCEVKCERCKEV------------------------------------- Nematostella_vectensis_wnt4 SKKNCDEIGQLSNHRQVQVCKRNIQ-VMDSVKDGASVALFECQHQFRYRPWNCTTVQFSRSPV-------------------------FG-NSINGGT--REAAFVHAISSAGVAYAVTQACSSGRLGQKCGCDRK--------TRG-QAD-------------------------------------GFNWGGCS-DDIDFGMTFATRFVDARERGSGIGSPARVL-------------------MNLHNNRGGRLAVRKFMDLQCKCHGVSGSCNIKTCWRALPNFR-IVGDYIKEKFD-GATEVE--------------------------------------------------------------------------------------------------------------------------YKLIGGKH----VLVPKNRKYKPHTQMDLVYLVQSPDFCEPNPKTGSLGTQGRIC-NR----------TSQAIDGCDLMCCGRGYVSR--TEVRQEQCAC-KFFWCCHVRCQTCMRRVEVSYCK*----------------------------- Nematostella_vectensis_wnt5 QPGLCMNLGGLTR-EQIDLCQKNID-HMASVGLGAKMAIQECQFQYQYEKWNCSIPDAEKSS------------------------LFER-ITSKDVA-TREAALTYAISSAGVVWALARACTEGNL-STCSCSRER--------RPL------------------------------------DLNKEYQWGGCG-DNIEYAVKFGREFMEAGEDHRPTEEDRKKY---------------ARTLMNLHNNNLGRRVVKDISVVECKCHGVCGSCNLKTCWRQLVEFR-EIGNALHDKYD-AAVQVALKRKEGRS----LLLPMR-------------------------------------------------------------------------------------------------------SRHYSQRK-----------AKSAQETRDELVYIDKSPDFCSKNAAHGAQGTRGRKCIKE-----------SLGKDGCNLLCCSRGYKMK--KEVQATRCRC-KFHWCCKVKCKTCIKNVTTHICN*----------------------------- Nematostella_vectensis_wnt6 ----------------------------------------------------------------------------------------------------------------------------------MGLDE------------------------------------------------AER-HDFGRRGCQHVYTQFGFDTAKQFMDPMGS---------RD---------------AKALISRHNNKAGRLAVKNHMEKKCRCHGLSQTCQMKTCWWELPAFR-SVSDRIKTHFD-GAVKVYVDNKGE---------------------------------------------------------------------------------------------------------------------RIIAEE-----------STVKPPTEEDLVYTTRSPDFCNSEYRTGSLGTRGRTCNET-----------SQGTGGCELLCCGRGYERT--VINEEVNCRC-RFHWCCEVRCKKCKKERVVFTCK*----------------------------- Nematostella_vectensis_wnt7 PSIICTRIQPLSA-KQMRFCEDKPG-TMVSISQGYDLGVEECKYQFRNKRWNCSLLGEER---------------------------PFG--QRAVPG-TKEAAFTHAIISAGIVQAVTLACTQ-NP-TGCGCDRNK--------DG---I----------------------------------SREGWKWGGCS-VNIGHGLAVAKEFLNAND--------AVRS---------------DIALMNRHNNEVGREVVNRSLLTECTCHGPSASCVTRTCSQALPSPR-AVSNRLKALYD-TARRATVYLSS------------------------------------------------------------------------------------------------------------------------LVR-P---------DDKVEKVKPMDLAYLKDSPNYCTKNTLSKLPGTLGGNCKISD---------DSQEEENCDVMCCGRGYDTH--LITKRWQCRC-KFVWCCNVRCSTCSKRDIVQTCK*----------------------------- Nematostella_vectensis_wnt8 --------------------------------------------------LDCFLAFT----------------------------------------ANRETAFVHSINTAAVTYFLTRDCRRGIF-RNCACVR------------QTGQA------------------------------------GEWRG-CN-DNVKFGEVLSKHFLNARHVDKR----------------------KARAVIHLHNNAVGRKAVKKTLKQQCKCHGVSGGCSSKSCWKTLPLFS-EIGDYLKAKYQ-QAQKVRLHT------------------------------------------------------------------------------------------------------------------------NKLVLKLPSRVFAPLTK-----KARRSLVFLKPSPDYCHRDTKKGSTGVLGRECSSDS-----------PNYLECIQMCTSCDYRVEKKLAVRSSKCNC-KFVWCCDIKCSECKKLVAVTKCVR*---------------------------- Nematostella_vectensis_wnt8b -MPCQGQSRKKMAVLKVLRGREAYDKLVSSIQKGAKLGLQECRSQFRNEKWNCTMAVKT-----------------KNKSTSKQNPAYVM---SMVPHATREMAFAHGISAAGVTFALTMDCRLGAF-EDCSCIHG----------KSEGNK------------------------------------GNWWGGCN-ENVKFGEVMARHFLEALQSGK-----------------------DERSLLNVHNNEVGRKAVRATLKRECRCHGISGSCSTRTCWRKLSSFA-EVGQYLVEKYS-TAKRVIFQ-------------------------------------------------------------------------------------------------------------------------NGNFYELTMLGTRPISK-----KDN-NFIYSESSPDYCQRNMTVGSAGVLGRECEGSK-----------DELVRCRQLCDSCRFDTQEFTEIKNTFCNC-KFHWCCKVKCMTCKETTRKTRCVARQQAL*----------------------- Nematostella_vectensis_wntA VTQFCSLMPWMKP-HQKQKCLLEPL-VMPSVQRGVGMALEECPSHYSDHKWNCSGVNTAQVFQ----------------------------ERGILKTNTKESAFVFALTSAGVSFQITKGCSLGNW-EQCGCDTQV--------RGRVQTK---------------------------------DEASWEWGGCS-ENVGHGDDFSRKFMDPEP--------PRKE---------------LEYLLVKHNNEAGRKALKDNMGKTCKCHGVSGSCTVKICWRTMPNFS-VVPQLLRKKFD-QATKVKANDK------------------------------------------------------------------------------------------------------------------KTKLQRITRGKRGK-----KKRQKGRRPSAGDLVFAEKSPKFCIPNPELGILGTRGRVCDAN-----------AKDNRGCKKMCCNRGYDT--------VKCNC-EF-WCCKVQCDMCKKDWTEYRCR------------------------------ Strongylocentrotus_purpuratus_wnt10 TQTLCRTFPGMNR-KQMQLCRRMPD-VTAAAIQGIDMAVHECQHQMKNRRWNCSSLEMRHGNP-------------------------FA-HALMSRG-LKETAFAHSLASAGVLYQVTRSCSAGKL-PYCGCDTRFV-------GSGE---------------------------------------GFEWGGCS-HDIKFGEGFAIDFLDSSEK----SGRDAQA------------------RMNLHNKRAGRLAVSHYAEKRCKCHGMSGSCQLKTCWMQTPHFR-EVGNRLMEKFS-LALEIRARNT--------------------------------------------------------------------------------------------------------------------NSGSVELVTRAR-SQFSTPRKKRRFPPQEELVFLEKSPDFCDADTRLDSPGTRERYCNRTS-----------TGIDGCDSLCCGRGYNIR--LERRTEWCNC-TFHWCCYVRCQQCHSSQWVNQCK*----------------------------- Strongylocentrotus_purpuratus_wnt3 VEIPCKGITNISG-KQVRFCLKNQD-KMPTVAEGAYHGIEECQFQFRGRRWNCTTIDGDQ--------------------------SVFG--RVLD-RASRETAFVNAILAAGVTHAVTRACSRGDY-LECGCDRT--------HRGPPGGRI-----------------------------GIVPNSTWRWGGCS-EEVWYSMELTKDFLKPTA---------AKR---------------ARTKMDRHNTDAGRNAVLHNMELRCKCHGVSGSCELKTCWWEMAPFR-KLGDALKTKYD-MAAEMAVERQRKGRTFV---------------------------------------------------------------------------------------------------------------EELAPRY-----------DDFKEPTTNDLIYYDQSPDYCTFDQEVGSFGTQGRECNRT-----------SHGIDGCELLCCGRGHNTM--TVVRRERCDC-VFVWCCKVVCKECVRVIDVHTCK*----------------------------- Strongylocentrotus_purpuratus_wnt5 TQPLCSELLGLSP-GQQKLCQLYQD-HMAPIGEGAKMSIDECQNQFTNRRWNCSTVD--SNN-------------------------VFG--KVLSIS-SREAAFTYAITSAGVVNAISRSCREGQL-STCGCGKSP--------RPP------------------------------------DIPRDWVWGGCG-DNIDYGFRFAREFVDAREMETNPQRGSFAY---------------DRMKMNLHNNEAGRKAVYDNAGTECKCHGVSGSCSLKTCWLQLSPFN-RVGTILKDKYD-GATNVRVNKKG----------------------------------------------------------------------------------------------------------------------RLVNSD-----------ARFNKPTRDDLVYLQPSPDYCLPDIQTGSLGTTGRECNKT-----------SMGTDGCTLMCCGRGYNSF--TKEVVERCKC-KFKWCCYVKCRKCRTLVDVHVCK*----------------------------- Tribolium_castaneum_wnt1 YMDLSSAHGTLRR-KQRRLARENPG-LLVALHKGANNAIHECQHQFRNQRWNCSTRAFPRGK------------------------NLFG--KIVDK-GCRETAFIYAITSAAVTHAIARACSEGSI-DTCNCETH--------YKGRPHVSGNGG------------------------GAAVAGVRDFEWGGCS-DNIGFGFTVSREFVDAGER-------GKT----------------IREKMNLHNNEAGRWHVKDQMRQECKCHGMSGSCTIKTCWMRLPPFR-VIGDLLKDRFD-GASHVAASGHHRNNNNAHQNRPPKNPKLNAISSNSIHSKRENR-------------------------------------------------------------------------------RKHKYGFQLKPFN-----------PEHKPPGTKDLVYYEMSPGFCEKNPKLGIQGTHGRLCNDT-----------SMGVDGCDIMCCGRGYRTQ--EVVVFERCNC-TFHWCCEVKCDVCRTKRTIHTCV*----------------------------- Tribolium_castaneum_wnt10 GNTVCRTTPGFSR-LQLELCYRYPE-EMLAALQGIRQAVKECHYQFFNYRWNCSSLSTKTKNP-------------------------YT-SGIFRKG-FRETAFAYAISSAGIAISVAKSCSRGVL-TNCGCEMHQH-------RHNN------------------------------------TKGAWKWAGCS-HNLHYGSKFSKMFFESKE-----VNDDIHS------------------QVSLHNSKIGRMTVFANMQIKCKCHGLSGSCELKTCWKQVPNFH-YVGKSLKEKFE-SAIQVDQANYFTNRNFKIIN----------------------------------------------------------------------------------------------------------YKKKLKQRIKSR-QWTPHKKKHKRGLKN-NLLFYEKSPHFCDAAPPLDVWGTSGRLCSLNA-----------TDQSSCSSLCCGRGYNLV--KQRRTVSCFC-VFRWCCTVECRDCIEEKWISICK*----------------------------- Tribolium_castaneum_wnt11 -----------------------ME-AMPHVQKAAVLAADTCQTVFKDRRWNCSSITTAPYLT-------------------------PD---LTRAT--REQAYVYAISSAALTYTMARACASGTL-YHCTCAGK--------PDEPPNS-------------------------------------NFQWGGCG-DNIHWGVYFAKRFIDNVEKNNVDKSRKRRKGYEYDEDRKSKLVREEIAAVNLHNNRVGRRIIRESIQTQCKCHGVSGSCNVKTCWKGLPPMF-EIGRKLMKQYT-NAKEVS---------------------------------------------------------------------------------------------------------------------------RYYVEGN-----------LGKTRISDHLLYLSKSPDYCTKDVKLGSFGTVGRKCNVT----------TN-ETNSCRQLCCGRGYRTL--VEEKLERCHC-KYYNCCYVKCKICRTKTQIYECG*----------------------------- Tribolium_castaneum_wnt5 GPPTCHTLPGLSP-GQIRLCQLYMD-HMNAVALGARQALSECKHQFENRRWNCSLLN--DVN-------------------------VFG--PVITIA-SRESAFAHALASAGVSYAVSRACRDGQL-ASCGCSRMG--------RPK------------------------------------DLRKDWVWGGCG-DNLEYGYKFTQNFVDVREKERKFKRGSKEQ---------------GRNLMNLHNNEAGRRAVIKKSKVTCKCHGVSGSCSLITCWQQLATFR-EIGDYLRDKYD-GATEVRINRRG----------------------------------------------------------------------------------------------------------------------RLQLRD-----------TRFRVPTAYDLVYMEDSPNYCIRDERVGSLGTQGRTCNRT-----------SQDLDGCNLLCCGRGYNTL--KSTIKERCHC-KFKWCCEVECKTCVRSVDVHTCK*----------------------------- Tribolium_castaneum_wnt6 PRTICKKTKRLRG-KMAEICS-KQA-LVDQIRLGVELGQRECQYQFRFRRWNCTSSRKS-----------------------------IR--KVLLR-DTRETGFVNAVLAAGVTYQVTRACTTGEL-LGCSCDR--------KMKSKKNKKRLKM------------------------ASMPEG--DWEWEACGGENIDFGLKKSKDFLDTRYK-------KRSD---------------MKTLVKLHNYVAGRMAIKNHMRTECKCHGLSGSCTLKTCWRKMPPFR-EVGNRLKERFD-GAVKVIAGNDGQ---------------------------------------------------------------------------------------------------------------------SFMPED-----------SSIKPPGKTGLVYSEESPHFCLPNNTLGSFGTQGRTCVET-----------SPGEEGCSILCCGRGSRSH--DETEEKNCKC-KFLWCCEVKCEKCNETRTISTCL*----------------------------- Tribolium_castaneum_wnt7 SEVFCSRIPGLTS-RQREMCRSSPD-AMVAVGDGIRLATAECKYQFRHQRWNCTGIDNPT---------------------------SFG--HVVIVG-SREAAFTYAISSAGVAYAVTSACARGNI-SACGCAPGP--------KL-REP----------------------------------APSGWKWGGCS-VDINFGMRFARKFMDARE--------LEGD---------------ERSVMNLHNNKAGRKAVKMSLLTECKCHGVSGSCTMKTCWKTLPGFR-QVGDNLMKKYY-RARPVTSVPSSPGPRGIDSF------------------------------------------------------------------------------------------------------RRPRKVHLVLKKGK---------IAIKKMPKKSDLVFLQTSPNYCERDLAAGSLGTVGRSCNRT-----------SRGNDGCDLMCCGRGYNTH--QYTRTWQCRC-KFHWCCYVDCDTCSERTEEYTCK*----------------------------- Tribolium_castaneum_wnt8 INSLFKSKTILQFNQDLN------PVIIESVANGAQMAMDECRNVFKWDRWNCPQSAFSRQNNH---------------------------------LATKEKAYTNAIITAGIIYSITRDCSQGVI-KGCGCDPKLRKNIYQEAKTKNLER------------------------------------DWTWGGCS-DDSSFGEELVLKLLEDNEESS-----------------------DAQAFINRHNNRIGREIIREKMLKTCKCHGVSGSCSFQTCWMQMPTFP-EIAKQLRERYD-RAIMISFERV-----------------------------------------------------------------------------------------------------------------------QGALTLGNSARHMPLESAG---DVLPNLLYLEKSPDFCLSNNSTGWPGTRGRTCSRTTSASMAE-------RKSCRNLCRSCGFRVRKQEKKVTKRCNC-KFIWCCEVECDVCVEYVNEFTCH*----------------------------- Tribolium_castaneum_wnt9 ----MTGYVPMIS-NGSKLCWRQRG-LPDVLLTARNLSIISCQNQFQYDQWNCSKRD-----------------------------------FFFKKI-YRETAFMHSMAAAALTFSIARACSEGTL-AGCQCGEHG--------KPSNS-------------------------------------SKWQWGGCS-DNIKFAKKFTRRFLQLRKK----DDGNYQN------------------AIVKYNSEVGIRIVIENVQVVCKCHGLSGSCSLKVCYKKIQAFD-YVSKQLKGLYH-AAIYVEHENH--------------------------------------------------------------------------------------------------------------------IRPYKS------------------GKMGQKLVFLENSPSFC--------PTTVDRRCNNT---------------ENCATLCCGRGFYTT--QVHEINKCMC-R-------------WRKEMFNV*------------------------------ Tribolium_castaneum_wntA HKERCSKLEYLVE-SQKQLCSQYDR-ILPVIGNGARLAMDECQHQFRNSRWNCTAFPEKNVT--------------------------FG--NVITIR-SREAAYLSAVSAASVAFAVTRACSKGDL-TDCSCDTR--------MRQKKSH-------------------------------------KWKWGGCS-EDIKYGEKFSRDFLDSKED--------DKT---------------ADGLMNLHNNEAGRRSVKSRMVRTCKCHGVSGSCSMQICWRRLPPFR-KVGDALFQRYE-GASHVKFVERKW-------------------------------------------------------------------------------------------------------------------RKKLKAIS-----------ADLKKPNKTDLVYLDDSPDYCEKNETLSILGTHGRICNRT-----------SQGIDGCRLLCCGRGYQTR--VREVEEKCKC-HFVWCCNVVCDICRYRREEHVCN*----------------------------- Xenopus_tropicalis_wnt16 EKLGCTNLP-LSF-HQKEMCRKKPY-LLSSIREGARLGIHECRNQFKHERWNCSVSPTISSAS-------SSFSLSFITSSLASAHTIFG---YELSSGTKETAFISAVTAAGLVHSVTRACSAGNM-TECSCDTSLQNG-----GSASEG--------------------------------------WHWGGCS-DDLQYGMWFSRKFLDAPYKN-----SSGRDSDVLN-------------AMHLHNNEAGRQAVTKLMTVDCRCHGVSGSCAVKTCWKSMSSFE-KIGNFLKNKYE-NSIQIADRLKRKVRR-----------------------------------------------------------------------------------------------------------------REKNDRKI------------PIYKG--DLVYTNKSPNYCVEDPKLGISGTHGRECNRT-----------SEGSDSCNLLCCGRGYNTH--VVRHVERCEC-KFVWCCYVRCRRCESMTDVHTCK*----------------------------- ; END; BEGIN TREES; TITLE Tb11336; LINK TAXA = Taxa1; TRANSLATE 1 Acyrthosiphon_pisum_wnt16, 2 Achaearanea_tepidariorum_wnt2, 3 Branchiostoma_floridae_wnt1, 4 Branchiostoma_floridae_wnt11, 5 Branchiostoma_floridae_wnt3, 6 Branchiostoma_floridae_wnt4, 7 Branchiostoma_floridae_wnt6, 8 Branchiostoma_floridae_wnt7b, 9 Branchiostoma_floridae_wnt8, 10 Capitella_teleta_wnt1, 11 Capitella_teleta_wnt10, 12 Capitella_teleta_wnt11, 13 Capitella_teleta_wnt16, 14 Capitella_teleta_wnt2, 15 Capitella_teleta_wnt4, 16 Capitella_teleta_wnt5, 17 Capitella_teleta_wnt6, 18 Capitella_teleta_wnt7, 19 Capitella_teleta_wnt8, 20 Capitella_teleta_wnt9, 21 Capitella_teleta_wntA, 22 Helobdella_robusta_wnt1, 23 Helobdella_robusta_wnt10, 24 Helobdella_robusta_wnt11a, 25 Helobdella_robusta_wnt11b, 26 Helobdella_robusta_wnt11c, 27 Helobdella_robusta_wnt16a, 28 Helobdella_robusta_wnt16b, 29 Helobdella_robusta_wnt2, 30 Helobdella_robusta_wnt4, 31 Helobdella_robusta_wnt5a, 32 Helobdella_robusta_wnt5b, 33 Helobdella_robusta_wnt6, 34 Helobdella_robusta_wnt7, 35 Homo_sapiens_wnt1, 36 Homo_sapiens_wnt10a, 37 Homo_sapiens_wnt10b, 38 Homo_sapiens_wnt11, 39 Homo_sapiens_wnt16, 40 Homo_sapiens_wnt2a, 41 Homo_sapiens_wnt2b, 42 Homo_sapiens_wnt3, 43 Homo_sapiens_wnt3a, 44 Homo_sapiens_wnt4, 45 Homo_sapiens_wnt5a, 46 Homo_sapiens_wnt5b, 47 Homo_sapiens_wnt6, 48 Homo_sapiens_wnt7a, 49 Homo_sapiens_wnt7b, 50 Homo_sapiens_wnt8a, 51 Homo_sapiens_wnt8b, 52 Homo_sapiens_wnt9a, 53 Homo_sapiens_wnt9b, 54 Lottia_gigantea_wnt1, 55 Lottia_gigantea_wnt10, 56 Lottia_gigantea_wnt11, 57 Lottia_gigantea_wnt16, 58 Lottia_gigantea_wnt2, 59 Lottia_gigantea_wnt4, 60 Lottia_gigantea_wnt5, 61 Lottia_gigantea_wnt6, 62 Lottia_gigantea_wnt7, 63 Lottia_gigantea_wnt9, 64 Lottia_gigantea_wntA, 65 Nematostella_vectensis_wnt1, 66 Nematostella_vectensis_wnt10, 67 Nematostella_vectensis_wnt11, 68 Nematostella_vectensis_wnt16, 69 Nematostella_vectensis_wnt2, 70 Nematostella_vectensis_wnt3, 71 Nematostella_vectensis_wnt4, 72 Nematostella_vectensis_wnt5, 73 Nematostella_vectensis_wnt6, 74 Nematostella_vectensis_wnt7, 75 Nematostella_vectensis_wnt8, 76 Nematostella_vectensis_wnt8b, 77 Nematostella_vectensis_wntA, 78 Strongylocentrotus_purpuratus_wnt10, 79 Strongylocentrotus_purpuratus_wnt3, 80 Strongylocentrotus_purpuratus_wnt5, 81 Tribolium_castaneum_wnt1, 82 Tribolium_castaneum_wnt10, 83 Tribolium_castaneum_wnt11, 84 Tribolium_castaneum_wnt5, 85 Tribolium_castaneum_wnt6, 86 Tribolium_castaneum_wnt7, 87 Tribolium_castaneum_wnt8, 88 Tribolium_castaneum_wnt9, 89 Tribolium_castaneum_wntA, 90 Xenopus_tropicalis_wnt16; TREE Fig._1 = [&R] (((((67,((38,4),(((12,(26,24)),56),(83,25)))),((59,((44,6),(71,15))),30)),(((((80,(45,46)),((60,(16,(31,32))),84)),72),((74,((8,(48,49)),(86,((34,18),62)))),(((29,2),((14,58),(40,41))),69))),(68,((1,((13,57),(27,28))),(90,39))))),(((77,(89,(64,21))),(((3,(35,(81,((22,10),54)))),65),(((47,7),(61,(33,17))),(85,73)))),((((((36,37),78),((82,(23,11)),55)),66),(88,((63,20),(52,53)))),(87,((75,76),(19,(9,(51,50)))))))),(70,(79,((43,42),5)))); END;