#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on April 25, 2024; 15:20 GMT TreeBASE (cc) 1994-2008 Study reference: Cao L. 2014. Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages. BMC Evolutionary Biology, 14: 10. TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S14979] BEGIN TAXA; TITLE Taxa1; DIMENSIONS NTAX=88; TAXLABELS Amphimedon_queenslandica_GI_340369567 Amphimedon_queenslandica_GI_340370065 Amphimedon_queenslandica_GI_340373128 Amphimedon_queenslandica_GI_340373665 Amphimedon_queenslandica_GI_340374274 Amphimedon_queenslandica_GI_340376468 Amphimedon_queenslandica_GI_340376480 Amphimedon_queenslandica_GI_340377763 Amphimedon_queenslandica_GI_340378990 Amphimedon_queenslandica_GI_340379451 Amphimedon_queenslandica_GI_340379787 Amphimedon_queenslandica_GI_340380250 Amphimedon_queenslandica_GI_340380414 Homo_sapiens_CABLES1 Homo_sapiens_CABLES2 Homo_sapiens_CyclinA1 Homo_sapiens_CyclinA2 Homo_sapiens_CyclinB1 Homo_sapiens_CyclinB2 Homo_sapiens_CyclinB3 Homo_sapiens_CyclinC Homo_sapiens_CyclinD1 Homo_sapiens_CyclinD2 Homo_sapiens_CyclinD3 Homo_sapiens_CyclinE1 Homo_sapiens_CyclinE2 Homo_sapiens_CyclinF Homo_sapiens_CyclinG1 Homo_sapiens_CyclinG2 Homo_sapiens_CyclinH Homo_sapiens_CyclinI Homo_sapiens_CyclinI2 Homo_sapiens_CyclinJ Homo_sapiens_CyclinJL Homo_sapiens_CyclinK Homo_sapiens_CyclinL1 Homo_sapiens_CyclinL2 Homo_sapiens_CyclinO Homo_sapiens_CyclinT1 Homo_sapiens_CyclinT2 Homo_sapiens_CyclinY Homo_sapiens_CyclinYL Homo_sapiens_Fam58A Homo_sapiens_Fam58B Monosiga_brevicollis_GI_167517989 Monosiga_brevicollis_GI_167522783 Monosiga_brevicollis_GI_167523717 Monosiga_brevicollis_GI_167524110 Monosiga_brevicollis_GI_167526102 Monosiga_brevicollis_GI_167526156 Nematostella_vectensis_GI_156350442 Nematostella_vectensis_GI_156359300 Nematostella_vectensis_GI_156359932 Nematostella_vectensis_GI_156363375 Nematostella_vectensis_GI_156364707 Nematostella_vectensis_GI_156365799 Nematostella_vectensis_GI_156365937 Nematostella_vectensis_GI_156375154 Nematostella_vectensis_GI_156380901 Nematostella_vectensis_GI_156381346 Nematostella_vectensis_GI_156389378 Nematostella_vectensis_GI_156397054 Nematostella_vectensis_GI_156405242 Nematostella_vectensis_GI_156406586 Nematostella_vectensis_GI_156407073 Nematostella_vectensis_GI_156408249 Salpingoeca_rosetta_GI_326426811 Salpingoeca_rosetta_GI_326428978 Salpingoeca_rosetta_GI_326429298 Salpingoeca_rosetta_GI_326435281 Salpingoeca_rosetta_GI_326437558 Salpingoeca_rosetta_GI_326437566 Salpingoeca_rosetta_GI_326437823 Salpingoeca_rosetta_GI_326437989 Thecamonas_adhaerens_GI_195998946 Thecamonas_adhaerens_GI_195999522 Thecamonas_adhaerens_GI_196000815 Thecamonas_adhaerens_GI_196001479 Thecamonas_adhaerens_GI_196002535 Thecamonas_adhaerens_GI_196003236 Thecamonas_adhaerens_GI_196003740 Thecamonas_adhaerens_GI_196005765 Thecamonas_adhaerens_GI_196007260 Thecamonas_adhaerens_GI_196007480 Thecamonas_adhaerens_GI_196011367 Thecamonas_adhaerens_GI_196012973 Thecamonas_adhaerens_GI_196013209 Thecamonas_adhaerens_GI_196013340 ; END; BEGIN TAXA; TITLE Taxa2; DIMENSIONS NTAX=76; TAXLABELS Amphimedon_queenslandica_GI_340369066 Amphimedon_queenslandica_GI_340369314 Amphimedon_queenslandica_GI_340371337 Amphimedon_queenslandica_GI_340373367 Amphimedon_queenslandica_GI_340377126 Amphimedon_queenslandica_GI_340379293 Amphimedon_queenslandica_GI_340380476 Amphimedon_queenslandica_GI_340381019 Amphimedon_queenslandica_GI_340381980 Amphimedon_queenslandica_GI_340383363 Amphimedon_queenslandica_GI_340384408 Homo_sapiens_CDK1 Homo_sapiens_CDK10 Homo_sapiens_CDK11B Homo_sapiens_CDK12 Homo_sapiens_CDK13 Homo_sapiens_CDK14 Homo_sapiens_CDK15 Homo_sapiens_CDK16 Homo_sapiens_CDK17 Homo_sapiens_CDK18 Homo_sapiens_CDK19 Homo_sapiens_CDK2 Homo_sapiens_CDK20 Homo_sapiens_CDK3 Homo_sapiens_CDK4 Homo_sapiens_CDK5 Homo_sapiens_CDK6 Homo_sapiens_CDK7 Homo_sapiens_CDK8 Homo_sapiens_CDK9 Homo_sapiens_CDKL1 Homo_sapiens_GSK3alpha Homo_sapiens_MAK Monosiga_brevicollis_GI_167516186 Monosiga_brevicollis_GI_167516210 Monosiga_brevicollis_GI_167516962 Monosiga_brevicollis_GI_167517533 Monosiga_brevicollis_GI_167522415 Monosiga_brevicollis_GI_167522771 Monosiga_brevicollis_GI_167525607 Monosiga_brevicollis_GI_167525918 Monosiga_brevicollis_GI_167536606 Monosiga_brevicollis_GI_167538010 Nematostella_vectensis_GI_156349526 Nematostella_vectensis_GI_156360882 Nematostella_vectensis_GI_156365870 Nematostella_vectensis_GI_156374066 Nematostella_vectensis_GI_156383566 Nematostella_vectensis_GI_156385093 Nematostella_vectensis_GI_156391793 Nematostella_vectensis_GI_156392090 Nematostella_vectensis_GI_156398520 Nematostella_vectensis_GI_156403969 Nematostella_vectensis_GI_156407302 Nematostella_vectensis_GI_156408568 Salpingoeca_rosetta_GI_326426444 Salpingoeca_rosetta_GI_326430756 Salpingoeca_rosetta_GI_326431660 Salpingoeca_rosetta_GI_326434528 Salpingoeca_rosetta_GI_326436991 Salpingoeca_rosetta_GI_326436992 Thecamonas_adhaerens_GI_195996637 Thecamonas_adhaerens_GI_195996663 Thecamonas_adhaerens_GI_195998898 Thecamonas_adhaerens_GI_195999760 Thecamonas_adhaerens_GI_196000717 Thecamonas_adhaerens_GI_196001193 Thecamonas_adhaerens_GI_196001971 Thecamonas_adhaerens_GI_196002669 Thecamonas_adhaerens_GI_196003954 Thecamonas_adhaerens_GI_196010283 Thecamonas_adhaerens_GI_196013334 Thecamonas_adhaerens_GI_196013348 Thecamonas_adhaerens_GI_196015356 Thecamonas_adhaerens_GI_196015366 ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M20995] TITLE Metazoan_CDK; LINK TAXA = Taxa2; DIMENSIONS NCHAR=283; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 ] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . ] Amphimedon_queenslandica_GI_340369066 YEKLEKLGEGTYATVYKGKSNITGKLVALKEIRLEH-EEGAPCTAIREVSLLKDLKHANIVFLHDIIHTARSLTLIFEYVEQDLKQYLDQCSGMMAMPNVKLFLFQLMRGLQYCHSRKILHRDLKPQNLLISEQGDLKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSIDYADSIDMWGVGCIFYEMIVGRPMFPGANVEEELVLIWKSLGTPNEKTWPGITKNKEFISHSFLRYDPQPLGLIVPRLDKEGINLMSKLLSYESQERLLARDGMKHNYF Amphimedon_queenslandica_GI_340369314 FEILSQIGEGTFGKVYKAKDLKTGEVIALKKVLIDSEREGFPITAVREIKILRQLRHENIVTLKEIISDSSSFYLVFEYCAHDLMGLIDSGMVVFSESHIQSLMRQLMEALCYCHSKNFLHRDLKCSNILINNKGQLKLGDWGLARYYFAHSRLYTNHVITLWYRPPELLLGAEHYGPAVDIWSCGCILGELFTKKPLFHGSIEMEQLDAISRVCGTPTPANWPEVIKLPLFQTFKFKKLYRRRVKEEYSNIPEVPLDLLDKLISIDPSKRISSEEALNHPFL Amphimedon_queenslandica_GI_340371337 FNKLNRIGEGTYGVVYRAEDKKSKEIVALKRIRMENEEEGLPICSVREIGLLLSLSHENIVQLKEIAVGLDNMFLVMNYCEQDLASLIDNMASPFTEPQVKCIMLQLLEGLSYLHNNHVIHRDLKVSNLLLTDKGILKIADFGLARTLGRPLKPLTPTVVTLWYRAPELLFGSREYSCSLDMWSVGCIFGELLLNKPLLPGKSEANQIELITNLIGSPNEGIWPGYSKLPLVASLEIKRQPYNNLKEKVYWISETGRGLLNDLLTYNPEYRMSSSRALRCKYF Amphimedon_queenslandica_GI_340373367 YRKLDILGEGQFATVYRAEDTERNAIVAVKKIKIGQARDGINRTALREIKLLQELHHPHILGLLDVLGHKSNISLIFDFMDTDLEMIIKDKSLLLPPGVVKAYSLMILQGLEYLHAHWILHRDLKPNNLLINKDGVLKITDFGLAKAYGSPNRIMTHQVVTRWYRSPELLFGARLYSTGVDLWAVGCIIAEMLLRLPFLPGETDLGQLSTIFEFFGSPNEENWPSVKSLPDYVE--FKPSPPQSFRDVFSAAGDDLIHLLESCMKLDPSKRCTASQALQSSYF Amphimedon_queenslandica_GI_340377126 YEKLTKVGQGTFGEVFKAKDRKTGRLVALKKVCMENEKEGFPMTALREIRILQLLQHNNIVNLVEICRSKGSIYLVLDFCEHDLAGLLECKEIKFSLSEIKNIMQQLFNALAYIHGNNILHRDMKSCNILVTRKGELKLADFGLARALNKANQRYTNRVVTLWYRPPELFLGERNYGPPIDMWGAGCIMAEMWTRRPIMQGDTEQKQITLICQLCGSISPTEWAGVEKLEYYQKLELPQKENRKLKERLRHEDPYALDLIDKLLMLDPRKRIDADSTLEHDFF Amphimedon_queenslandica_GI_340379293 YERLEKIGEGTYGVVYKARQATHGRVVALKKIRLDAECEGVPSTAIREISILKELDHVNIVSLLDVLYCDRKLFMVFEFLDYDLKKYMDRHAP---TGIPTDYLYQLLEGVAYCHAHRVLHRDLKPQNLLISSDGRIKLADFGLARAFGVPVRTYTHEVVTLWYRSPELLLGSQYYSTPVDIWSIGCIFAEMVTKRPLFPGDSEIDQLFRIFRTLGTPDESVWPGISSFPDYKSS-FPKWPRQNLQRIVKSLDTLGINLLEQMLCYEPCKRITAINGMRHPFF Amphimedon_queenslandica_GI_340380476 FEYEKKIGRGTYGHVYKAKKRSGDKEYALKQI----EGTGISMSACREIALLRELKHSNVISLQRVFLSDRKVWLLFDYAEHDLWHIIKYHQVQVPKTMVKSLMYQILSGIHYLHSNWVLHRDLKPANILVMERGRVKIADMGFARLFNAPLKPLDPVVVTFWYRAPELLLGAKHYTKAIDIWAIGCIFAELLTFEPIFHCRQEREQLERIFLVMGFPHDRDWDDMKHMPEYSTLMFGRQANCALQKYMVKHDTSAFKLLTKFLVMDPNKRITSDQAMLDTYF Amphimedon_queenslandica_GI_340381019 YTKLEKIGEGTYGVVYKARHKVTGKTVALKKIRLENEEEGVPSTAIREISILKEVQHTNVVKLEDIIHQDLKLYLVFEFMCMDLKKYLDSLPAFMEPDLVKSYTYQILKGIVFCHGRRIIHRDLKPQNLLIDNNGGIKIADFGLGRAFGIPVRAYTHEVVTLWYRAPEVLLGCPRYSCPLDIWSIGCIFAEMSNKKPFFQGDSEIDQLFRIFRILGTPSDAIWPSVTTMPNFKST-FPKWTGKSLSQLCPHLDSIGCDLLMQMVIYNPGKRISAKRAMEHPYF Amphimedon_queenslandica_GI_340381980 YKILGRIGEGAHGVVLKARHTQTGDLVALKRVHLKKPADGIPNSALREIKALQESGNHHVICLRDMFPHGPGFVLVFDYMLSDLAEVIRNAEKPLTEAQVKSYMTMLLKGVAYLHDNKIMHRDLKPANLLISQTGHLKIADFGLARVLSTEGRLYSHQVATRWYRAPELLYGARQYDTGIDMWAVGCIFGELLNTSPLFPGENDIDQLCCVLRILGTPSERIWPGMSQLPDYHKISFSEMSPTPMEVVVPDALPEAVDLLKSFLVYDSRHRLSAAKALLHSYF Amphimedon_queenslandica_GI_340383363 YEWLNRIEEGTYGVVFRARDIRTDEIVALKKLKMEKEREGFPITSLREISTLLKANHENIVNVREIVVGMDKIFIVMDYVEHDLKSLMETMKQPFLEGEVKTLLIQLLKAVHHLHDNWIIHRDLKTSNLLLSHKGILKVADFGLAREYGSPLKNYTPIVVTLWYRAPELLLGAKEYSTAIDVWSVGCIFAELLQHKPLFMGKSEIDELNLIFKELGVPNESIWPGFGELPVAKKVQFTQQPLNNLRKRFPMITKNGFVLLNKFFAYDPKRRVTAEDALKHEYF Amphimedon_queenslandica_GI_340384408 YERLEKIGEGTYGTVFKAKEKESGEIVALKIVRLDEDDEGVPSAALREICLLKELKHKNIVRLTDVLHKNLKLTMVFEYIDQDLKKYFDVSGGIISPQVVQSFFFQLLQGLAFCHYNNILHRDLKPQNILISKKGDLKLADFGLARAFGIPVRLFSAEVVTLWYRPPDVLMGAQVYNTSIDMWSAGTIFAELANGRPLFPGSDVDEQLKRIFKLVGTPTERSWPGLTKLPEFKEF--PPYPPACIESVVPALNDAGVDLLQRHLICHPTERISAEEAMRHEYF Homo_sapiens_CDK1 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT-FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF Homo_sapiens_CDK10 FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF Homo_sapiens_CDK11B FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGLLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF Homo_sapiens_CDK12 FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL Homo_sapiens_CDK13 FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFL Homo_sapiens_CDK14 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQE-EEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLVNHAEDLASKLLQCSPKNRLSAQAALSHEYF Homo_sapiens_CDK15 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNA-EEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNIEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLVPEAEDLASQMLKGFPRDRVSAQEALVHDYF Homo_sapiens_CDK16 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEH-EEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF Homo_sapiens_CDK17 YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEH-EEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF Homo_sapiens_CDK18 YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEH-EEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF Homo_sapiens_CDK19 FEYECKVGRGTYGHVYKARRKDGKKEYALKQI----EGTGISMSACREIALLRELKHPNVIALQKVFLSDRKVWLLFDYAEHDLWHIIKFHPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMERGRVKIADMGFARLFNSPLKPLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQFRRTANSSLIKYMVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYF Homo_sapiens_CDK2 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS-FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF Homo_sapiens_CDK20 YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMENQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF Homo_sapiens_CDK3 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGS-FPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF Homo_sapiens_CDK4 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGLPISTVREVALLRRLEHPNVVRLMDVCATEIKVTLVFEHVDQDLRTYLDKAPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ-MALTPVVVTLWYRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGA---FPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL Homo_sapiens_CDK5 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY--PMYATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF Homo_sapiens_CDK6 YECVAEIGEGAYGKVFKARDLKGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLEHPNVVRLFDVCTVETKLTLVFEHVDQDLTTYLDKVPEGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-MALTSVVVTLWYRAPEVLLQS-SYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQA---FHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF Homo_sapiens_CDK7 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVT--FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF Homo_sapiens_CDK8 FEYECKVGRGTYGHVYKAKRKDGKKDYALKQI----EGTGISMSACREIALLRELKHPNVISLQKVFLSDRKVWLLFDYAEHDLWHIIKFHPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMERGRVKIADMGFARLFNSPLKPLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMFRRNTNCSLIKYMVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF Homo_sapiens_CDK9 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKARDPYALDLIDKLLVLDPAQRIDSDDALNHDFF Homo_sapiens_CDKL1 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYF Homo_sapiens_GSK3alpha YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDK------RFKNRELQIMRKLDHCNIVRLRYFFYSKLYLNLVLEYVPETVYRVARKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYTEFKFPQIKAHPWTKVFKRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF Homo_sapiens_MAK YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKF-YSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQ-PPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYF Monosiga_brevicollis_GI_167516186 FDLVNEVGQGTYGQVSKARIKNTDQLVALKMLKMEADRDGFPVTALREIKILRQLRHESIINLIGIVADPAAFYLVFEYMEHDLYGLLSSKQCTLDQEQIRYLMFQLMDGLRYCHAKHFIHRDIKGANLLVDNQCRLKIADFGLARLYEDRSRAYTNNVITLWYRPPELLYGAEVYGPEVDVWSAGCILGEFFLCRPMFRAGTEIEQLHAISMACGTPDPTNWPEAQNLPAFKTLRPRKRYERNLAGFFRALYVRRLGLLSPLMGYSPTSR------------ Monosiga_brevicollis_GI_167516210 FRILGRIGEGAHGVVFKAKHIESGVVVALKRVGLKRIEAGIPVALLREIQALRHVQHPNVVRLHDAFAH------------------------------------------AACVLRGIIHRDLKPSNLLISPQGQLKIADFGLARIWHQDGRQYSHQVATRWYRAPELLFGARHYDLGVDLWAVGCIFAEMINSAPLFPGENDIDQLSCVLHTLGTPTPENWPEASTFPDYGKITFDETPGVPPEDLVRNTSPEGRTLFASFVPYSAKRRQSARSALRSLYF Monosiga_brevicollis_GI_167516962 FEKLNILGEGTYGVVYRARDSRTGHQVAVKQVKMNQERGGLPLSSLREITALQQLRHTNVLQLLHVAAGLTSIFLIMEYCEHDLAALVDNMPAPFPEPAVKCLMQQLFAGLDAMHRECLIHRDLKLSNLLLTDHGILKVADFGLTRVIEDPAHHMSPTVVTLWYRPPELVFGMKNYTRAVDIWSCGCIFAELLAHEPLFPAKTEVALLEMVIGLLGAPHESIWPAFRDLPLAHRFHMPHQPYSNLKQRFGFLSSTGLDLMQDLLMYDPEKRLSAIAASVHPYF Monosiga_brevicollis_GI_167517533 YLKIEKIGEGTYGTVYKAKVKATGNLVALKKIKLEAEEEGVPSTAIREISLLKELSHPNVVSLMEVIHSENKLYLVFEFLDQDLKKHIDSQRNGLSMELIKSYMLQLLKGIDFCHARRILHRDLKPQNLLINREGFIKLADFGLARAFGIPIRAYTHEVVTLWYRAPEILLGQRQYACPVDMWSIGCIFAEMVTRRPLFPGDSEIDELFRIFRVLGTPTEQTWPGVSQLPDYKDC-FPRWSGEGLASLIPGLDAMGLDLLQKMLRYEPSQRISARQALTHPWF Monosiga_brevicollis_GI_167522415 YKKLHKLGEGTYATVFKGISHINGKIVALKEIRLEH-EEGAPCTGIREVSLLKGLKHANIVTLHDVIHTKDNLIMVFEFLSKDLKAYMDDCNSYIDLRNAKLFLFQLLRGVGFCHSRKVLHRDLKPQNLLINHAGELKLADFGLARAKSVPIKTYSNEVVTLWYRPPDVLLGSVDYSGDIDMWGVGCIFGEMISGRPMFPGATNADQLELIFKTLGSPSESTWPGVMALPEAKSNELGAYSPQPVNAILPRLDKQGGALLKSLLKLDPHGRVSAVKAMQHPYF Monosiga_brevicollis_GI_167522771 YAKIDKLGEGTYGVVFKARDRHDGSIVALKRISLESAAEGVPSNAVREISLLKSLHHPNIVRLYDVLHSEHKLTMVFEYCDQDLKKFLDSCRGTPEHHVIQSFMFQLLQGIRHCHEERVLHRDLKPQNLLINKRGQLKLADFGLARPYGVPVRSYSHEVVTLWYRAPDVLLGATGYDTSIDMWSAGCILAEMANGSPLFPGTSVQDQLDLIFRVLGTPTIESWPGLHELPNYSGPFLPHVDGVGLEAEVSSLFPEGLDLLQQLLRYVPDERLSADRALRHRFF Monosiga_brevicollis_GI_167525607 FSPVGTGGEGTYGEVKRCRHVATQQIVALKKIKTEQEANGFPQTALREIQILKQLRHENIVQLQSVAVVGKFCYMVLEFVDHDLNRILTAIKSPVSTTIFKGLALQMLRGLDHLEKNCVLHRDLKPANILLSAQGVIKLADFGLAKYHHPDRKGHTALVCSQWYRPPELLAGQVSYPEKIDSWSLAVVMGELFNLDPLFDGRTSTYQFIQIQKLCGTDSFAWLEDCPLLPAKGH--KKRQVSQRFNTLIARSSEAVVAFMDKALTVDPNHRLLAGELLKWEHK Monosiga_brevicollis_GI_167525918 FANAGCVGQGTYGIVHKVYRLEGRKPYALKGMVTVSRTEGFSTANLRELALLRELHHDNVISLREAFIHTKEVWLLFDYAEYDLWWLCNDHNLRLQEPMLKSIMFQLLQGVHYLHEQWVLHRDLKPANVFLTRGGSIKIGDLGMARVFVAPPKAFDPVVVTYWYRAPEIMLGAKHYTKAIDIWSIGCIFAELINLVPIFHVKNDAAQLEAIFKVLGMPDEQKWSLLKHMPRYPDLKFKTK-----DDVLEPESSTRLSLMRRMFHYDPEKRISADEALTAPWF Monosiga_brevicollis_GI_167536606 YEKVKYLGEGQFGTVYLERDSQTGQLYAIKRIRLGDAKEGLNQSAFREIMFLREVHHPNIIDLHDVFLKKGNLHLVLELASTDLEKLIRNKRLDFAPGDVKSLLLQTYQALDYLHARWILHRDLKPNNILITTGGQVKLTDFGLACTFGSPSREMTTQVVTIFYRAPELLLGARHYGVGVDIWAMACIHMELELRTPILPGDGPFDQLDKIMAFLSSFGHAAQPNYRELSSSWE--FKPRDPTPIRALLPAVSDAAIDLLEKQFTYDPLKRPTARETLMHPYF Monosiga_brevicollis_GI_167538010 YEHLNRIDEGTYGVVFRVRDRSSGHIRAVKRLKMEKEKSGFPVTSLREINTMLKVRHENIVRVEEIVVGMDDIFIVMEFVEHDVKALLESIQKPLLQAEVKTLMLQLLSGVAHLHDNWILHRDLKTSNLLLSHRGILKIADFGLAREYGDPLKEYTTLVVTLWYRAPELLLGAKSYSTAIDMWSVGCIFSELLTRKPLFDGNGEIDTMNKMFKMLGVPDETRWPGLNDLPVPRSMSLRGPSENRLPRSYGILPSSGVNLLSDLLCYDPAQPYLEQQ--KQSRF Nematostella_vectensis_GI_156349526 FEKLNRIGEGTYGIVYRAKDTKSGKIVALKKVRMEQERDGIPISGLREITLLLNLRHENIVQLLEVVVGLDSLFLSMEYCEQDIASLLDNMSCPFSEAQIKCLMIQLLEGTKYLHEHFIVHRDLKVSNLLLTGKGVLKIADFGLARTFGYPYKPMTPVVVTLWYRSPELLLGAKVHTTAVDMWAVGCIFGELLGNKPLLAGKSEINQLQLIVDLLGTPNDHIWPGYSSLPGVKSISLKHQPYNNLKHKFSWVSQAGLSLLNYMLMYDPCKRATAAESLQSSYF Nematostella_vectensis_GI_156360882 YKKIDFLGEGQFATVFKAEDQETGNIVAVKKIKLGNAKDGINRTALREIKLLQELSHENVIGLLDVFGHKSSISLVFPFMETDLEVLIKDTCIVLSPADVKSFTIMTLKGLEYLHSHWILHRDMKPNNLLLDDKGVLKIGDFGLARAFGSPSRVYTHQVVTRWYRPPELLFGARIYGTGVDMWAEGCILAELLLRVPFLPGATDLDQLSRTFQTLGTPTEETWPGMTSLPDYVE--FKPFPGIPLKDIFSAAGDDMLDLLDRLLDCNPNGRVNATQALNMPYF Nematostella_vectensis_GI_156365870 YERQAKIGQGTFGEVFKAKNRKNKEIVALKKVLMDNEKEGFPITALREIKILQLLNHENVVKLLEICRTKASIYLVFEFCEHDLAGLLNNQAVKFSPPEMKKIMQMLLNALYFIHSNKILHRDMKAANILITKNGVLKLAEFGLARAIHIQKQRYTNRVVTLWYRPPELLLGERNYGPPIDLWGAGCIMAELWTRTPIMQGNTEQHQLTLISHLCGSITPEVWPGVDKLELFDKMVLPSGQKRRVKERLRMKDHNALDLIDKMLSLDPGPRIDADSALNHDYF Nematostella_vectensis_GI_156374066 YEEVAEIGTGAYGTVYKAKDLLDGKFVALKRVRIQNSEEGMPLSTIREIALLKQIAHPNVVRLLDIFHIETHLNLVFEHVDQDLAAYLEYCPQGLGEWKIKDLTYQILNGVDFLHTHRIVHRDIKPQNILVTKDGQVKIADFGLARVYKDA-MALTSVVVTLWYRAPEVLLQS-SYATSVDIWSVACILAELFNRRPLFEGKNDVDQLDKIFSIIGSPSQDEWPQNVSLPWTS---FSRYTTGSFQALVPEMCTEGTTLLKEMLQFLPRSRPSASEAMNHPFF Nematostella_vectensis_GI_156383566 FQWLNRIEEGTYGVVYRAKEKASGEVVALKRLKMEKEKEGFPITSLREINTLLKAQHPNIVHVREIVVGMDRIYIVMDYVEHDLKTLMEHMTSPFTVGEVKTLLIQLLRATAHLHDNWILHRDLKTSNLLLNNRGILKVGDFGLAREYGSPLRHYTPIVVTLWYRAPELLLGIKEYSCPIDMWSVGCIFAELLTMEPLFPGRSEIDQINRIFKELGTPSDKIWPGPSELPHVKKMTFTEYPYNQLRNRFGYLTDKGFSLLNRFLTYDPKKRITAETALKEDYF Nematostella_vectensis_GI_156385093 FEKVEKIGEGTYGVVYKARDKTTGRMVALKKIRLDTESEGVPSTAIREISLLKELNHPNVVSLLDVVHNQKSLYLVFEFLSQDLKKYMDCLPPGISTSLIKSYVYQLLSGVAYCHSHRVLHRDLKPQNLLIDKNGAIKLADFGLARAFGVPVRSYTHEVVTLWYRAPEILLGSRYYATPVDVWSIGCIFAEMKTRRALFPGDSEIDQLFRIFRTLGTPDDKVWPGVSELPDYKTS-FPKWPVQSIRHVLPTLDNTAIDLLQKMLTYQPNARISAKAALSHEFF Nematostella_vectensis_GI_156391793 FSKIEKIGEGTYGVVYKAKNLKTGGFAALKKIRLEVEDEGIPSTAVREISLLKELRHPNVVELQHILHQEPKLYLVFEYLTCDLKKHLDTTRGMLDKTLVKSYLYQITNAIYFCHARRILHRDLKPQNLLIDSKGLIKLADFGLGRAFGIPVRAYTHEVVTLWYRAPEVLLGGQRYSCPIDVWSIGTIFAEMVTKRPLFHGDSEIDQLFRIFRILGTPTEETWKGVTSLPDYKPT-FPKWAGDGLKKAVPQLDSDGLDLLKKMLIYDPALRISAKTSLKHPYF Nematostella_vectensis_GI_156392090 YQKLEPLGEGSYATVFKGLCTANKKIVALKQIRLQE-EEGAPFTAIREASLLKQLKHGNIVKLHDIIHTKDTLMFVFEFLDTDLNCYLEKYSRGICPHNTQLFCFQLLRGLAYIHDRKILHRDIKPQNLLISERGELKLADFGLARAKSVPSQTYSHEVVTLWYRPPDVLLGSKNYTTSLDIWGAGCIFVEMLTGIALFPGLNHIDQLNKIWQVLGTPTDETWPGVSKLPEYDPDIFINFRPRRIGQCIPRLVEGAEQLVIRMIQLDPKNRISAREAMRSTYF Nematostella_vectensis_GI_156398520 FDIIEQIGEGTYGQVYKAKDKITGELVGLKKVRTDNEKEGFPITAVREIKILCQLNHPNIINLKEIVTDKGAFYLVFEYMDHDLMGLLESGLVHLTEDHIKSFIRQLLDGLNYCHKKNFLHRDIKCSNILLNNKGEIKLADFGLARLYEAERRPYTNKVITLWYRPPELLLGEERYGPGIDIWSVGCILAELFTKKPIFPAYQEIGQLELISRVCGTPTPAVWPSIINLPHFHSIKPKRQYRRRIREEFNFLPEDALDLFDAMLTLDPSQRITAEKALEHPFL Nematostella_vectensis_GI_156403969 YTKLDKLGEGTYATVFKGKSKLTDNIVALKEIRLEH-EEGAPCTAIREVSLLKGLKHANIVTLHDTVHTQKSLTLVFEYLEKDLKQYMDDCGGIMSMNNVRIFLFQLLRGLDYCHKRKVLHRDLKPQNLLINDKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTAYSTQIDMWGVGCIFFEMATGRPLFPGSTVEDELLLIFKVLGTPSEEVWPGISANEAFIAGKFPDYPRENLIIHAPRLDNSGLELLEKFLEYTVKDRVSAHDAMRHDYF Nematostella_vectensis_GI_156407302 YDKLEKIGEGTYGTVFKGKNKETREILALKRVRLDDDDEGVPSSALREICLLKELKHNNIVRLYDVLHSEKKLTLVFEFCDQDLKKYFDSCQGEVDASVVKSFMFQLLRGLAFCHSHNVLHRDLKPQNLLINKDGELKLADFGLARAFGIPVRCFSAEVVTLWYRPPDVLMGAKLYSTSIDMWSAGCIFAEMANGRPLFPGNDVDDQLRRIFKILGTPTEESWPNVSKLPDYKEF--PPQPSVSLGMVVPKLSSTGRDLLQKLLVSNPAHRISAEDAMKHAYF Nematostella_vectensis_GI_156408568 YTILGRIGEGAHGIVFKAKHIESGEIVALKKVPLRRLEDGIPNTALREIKSLQENENPYVVKLIDVFPHGTGFVLVFEYMWSDLSEVLRNSERPLTEAQIKGYLLMLLKGVAYCHNKGIMHRDLKPANLLISSTGHLKIADFGLARVFSNEERQYSHQVATRWYRAPELLYGARKYDEGVDLWAVGCIFGELLNNSPLFPGENDIEQLCCVLKTLGTPNEEIWPGMTDLPDYNKITFPDMPAIPLEKIVPDASPEAMDLLKRFLVYPSKKRIPASEALLHPYF Salpingoeca_rosetta_GI_326426444 YVRICKVGEGTYGQVYKAQDRQNSQIVAIKAITLNGGAEGVPSNAVREISLLKRLDHPNIVRLLDVLYSQTRLMMVFEFCDQDLKQFLSHKPIQHDPNLAQTIMFQLLRAVAYIHSQHILHRDLKPQNILLDRKGRLKLADFGLARPIGVPVSKYTADVVTLWYRAPDVLLGSEHYGPCIDLWSTGVIFAEVLTGQPPFQGNSINEQLLLIFDMLGTPPP-SWD-MRQYERYKDFSMRHATSVGLETFLSRAAPVAVDLVKALLRYNPDARITAEAAMEHEFF Salpingoeca_rosetta_GI_326430756 YRIERRVGEGAHGVVFLGVHLASGQRVALKKVTLARLDDGIPTQVIREIRALCQLTHKNVVTLHDVFPSGMGIMLCFEYMASDLARVLQGQNLPLSAPHVKRYMSMLLSGVDFCHSHAIVHRDLKPANLLISATGQLKIADFGLARVYDE-ARPMSHQVATRWYRAPELLYGARVYDFGVDIWAVGCIFGELLNNSPLFPGENDIDQLSCVIQALGTPTRQDWPELDSLPDFAKINFDPTDPQPMHEILPDATQDAINLCSQFLVYSSSRRLPAAKALVHPYF Salpingoeca_rosetta_GI_326431660 FERLGRLGEGTYGIVYKAKDIETGAIVAVKRIKMKDEREGMPQTSLREVTTLKAMEHENVVQLLDIAVGHDQVYLIFEYCEHDLAWLVDNLPAPFPETVAKSLTVQLLKGLRALHSMFIVHRDIKLSNLLLNSRGYLKIADFGLARRSGDPPRPKTTNVVTLWYRAPELLFGDKAYTSKVDCWSAGCVMGELLAHKPILPGKSEVSQLDLIIQLLGTPNEAIWPGFSSLPLASRFQLTAQPYSNLKDEFRFISDRGIDLLQRLLTYDPHQRWSCDRALGHAYF Salpingoeca_rosetta_GI_326434528 YKKIAVLGEGQFGTVFLAEHTDTKERFAVKKIKVGSAEEGLHRTAFREIKFLQELRHANIIQLRDIFAKGFNIHLVLELCKCDMRAIILEN-IQLTPSDIKSLMLQCLQGLEYLHSHWIIHRDLKPENIFITRKGIVKLADFGLASTFGSPSRAYTAQVVTIYYRAPELLFNSKAYGAGVDVWAMGCVHGELELRRPLLPGTSEIDQLSRIFALRGSVNEHNWPGVTKLPGFLEVRFDQQNPTPLRHVMPAASDLALSLMDGLLTCDPAKRLTIKQALKHAYF Salpingoeca_rosetta_GI_326436991 FEKTEKLGEGTYGSVYKAIDKTTMAVVALKKIKLNDQEFGVPASALREIALLRELDHPNIVQLLDVIPSSSELHLILEYVYEDLRKFMHRVK-VLERPMYQSFLRQLLLGLEYCHIHRILHRDLKPENLLINHTGALKLADFGLARAFGIPVRAYTHEVVTLWYRAPEILLGSKQYACPVDMWAVGCIFAEMASSKPLFPGDSEVDQIMRIFRYLGTPTEKTWPGVSNLPDFRAN-FPRFPAIDLAPIVPQMDPVSMALLQHMLVYLPASRIPANQALKHPFF Salpingoeca_rosetta_GI_326436992 YEKIEKIGEGTYGTVYKAKLITSGELVALKKIKLETEEEGVPSTAIREISLLKELNHRNVVRLIEVIHSEHDLHLVFEFLDCDLKKHMEVS-RQLAPDLVRSYLFQLLKGIEFCHTHRILHRDLKPQNLLIDSDGNIKIADFGLARAFGIPVRAYTHEVVTLWYRAPEILLGARQYACPVDIWSIGCIFAEMVTTRPLFPGDSEIDELFRIFRYLGTPNEHVWPGVSELPDFKTT-FPQWKRQDLAKLVPGLDPTGLDLLEQMLRYAPSARISATRALRHPYF Thecamonas_adhaerens_GI_195996637 YDKLHKLGEGTYATVFKGRSKLTNDFVALKEIRLEH-EEGAPCTAIREVSLLKDLKHANIVTLHDTIHTERSLVLVFEYLDRDLKQYMDSCGSILDMSNVKIFLFQLLRGLAYCHSRRVLHRDLKPQNLLINERGELKLADFGLARAKSVPSKTYSSEVVTLWYRPPDVLLGSTEYSTSIDMWGVGCIFYEMATGLPMFPGSSTENQLQTIWEILGTPTEEEWSGLTRNLKVNSLSFHDCKGEPLRNRAPRLEADGLDLLAKFLQYKAKSRISSADAMKHKYF Thecamonas_adhaerens_GI_195996663 FTILGRVGEGAHGVVFKAKHVGNGEVVALKKIHLKKIDDGIPNNILREIKTLQAITHENIVRLFDVFPDGSSLVLAFEYMVTDLSEILRSSQNTLPE-VSSYYMIMLLRGISFCHENHIIHRDLKPANLLISSSGQLKLADFGLARVMSVEERLYSHQVATRWYRAPELLYGSRTYDEGVDLWYLGCIFAELINKSPLFPGDSDIKQLGCVLSILGTPTTSTWPGLIELPDYNKITFSGFLPIPFESIVPDATSEVGKIK----------------------- Thecamonas_adhaerens_GI_195998898 YEKITKIGHGTFGEVFKARNRISKEFVALKRVLLGNEKEGFPITSLREIKILRALKHDNIVRLQEICRSRGSIYLVFEFCAHDLAGLLQNPQVKFNLSEIKRMMKHLLSGLFYIHSNKVLHRDLKAANVLVTRDGVLKLADFGLARVYSRKTHCFTNRVVTLWYRAPELLLGCRDYGPAIDMWAIGCIMAEFWTRSAIMQGNSETNQLTLITQLCGSITPEVYPDVDKLDLFKKFDLPASQKRRVKERLSHRDRHALDLIDRCLTIDPAKRIDSDSALNHDFF Thecamonas_adhaerens_GI_195999760 YVQVTEIANGAYGRVYKARDLNHNRLVALKKIAVINDEQGIPISTIREITSLKSLGHQNIVRLYDIFANTMDLTLVFEHVEQDLQTYIRNCPSGIDTRKIKDIIYQIVNAIDFLHANRIVHRDLKPQNVLISRQGIVKVADFGLAKVFCEN-VPITSVVVTLWYRCPEVLLQS-TYATPVDMWSVGCIMAELYLREPLFCGQTDIDQLQKIFSMTGLPDESEWPVNIPFSRST---FCQYTRRQYSEMMPEICQDGVDLLQKLLKFNPKERLTAEESLQHPYF Thecamonas_adhaerens_GI_196000717 YEKLVKIGEGTYGTVYKAVNHDTGEIVALKKVRIDDENEGIPSFALREICLLKELKHKNIVMLYDVIHGNKELMIVFEYCDQDLKRYCDACQGKIDPSIVQSFTNQLLQGLAYCHSHHILHRDITPQNILVTGNGDIKLADFGLARNFGIPVKSFSAEVVTLWYRSPDVLLGATLYDTSIDIWSTGCIFAELSNGQPLLPGKDVADQLKIIFKIFGTPNEQIWPGVSQLMKDKDY--PSYNAMSILHVVPNLNQLGCDLFQLMMVLDPSKRCTAEQALQHAYF Thecamonas_adhaerens_GI_196001193 YEKLEPLGEGSYATVYKGYSIGHQKLVALKEITLNE-EEGTPFTAIREASLLKQLKHANIVVLHDIIQTPTKLTFVFEYVTTDLSQYLNLHPGGLNMKNVKLFLYQLLRGLSYCHQRRILHRDIKPQNILVSEIGEIKLADFGLARAKSVPSKTYSPDVVTLWYRPPDVLLGSTNYSTSLDIWGVGCIFTEMVSGIATFPGVRNIDQLDKIWHKLGTPTEETWPGVTSYPEYCAAETMFYESRTIAEVIPRLDPGAADLATKMLQYQPFKRIFCQAAMNHQYF Thecamonas_adhaerens_GI_196001971 YKKIKLLGEGQFAVVYQAEDTHKNKIVAVKKIKLGPANDGINRTALREIKLLQELKHENIIGLLDVFGHKSNISLVFDYMEADLEVIIKDSSIILTNAHIKQYIIMTLRGLEYIHSNWILHRDMKPNNLLIDSNGILKLADFGLARYFGSPNRYYTNQVVTVWYRAPELLFGANSYGTGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFQTLGTPIEDKWADIHKLPGYIK--FKTLPAIPLNEIFTAASDDMLDLLRRLFEYNPSSRITATEALQMKYF Thecamonas_adhaerens_GI_196002669 --ILKQIGEGTYGQVFKAKIKDTDKLVALKKVRTDHEREGFPITAVREIKILKQLNHQSIVNLLGIVSNRCAFYLVFEYMDHDLMGLLESGLVTFDEEHIRSFMRQIMEGLNYCHKRQLLHRDIKCSNLLMNNKGQIKIADFGLARFYNPKSRPYTNKVITLWYRPPELLLGEERYGPSVDVWSCGCILGEFFTKKPIFQANSEINQLDLISQICGTPCPENWPSVVELPYYNNFKLRKY-ERRLEQEFHDLPELAVDLMQYMLILDPSMRYNAEQSLQHPFI Thecamonas_adhaerens_GI_196003954 YLKIEKIGEGTYGVVYKGKNRNTQQLVALKKIRLENEEEGIPSTAIREVSLLKELKHPNIVDLIEVLYEESKLYLVFEFLDMDLKRYLDTLPKTIDAMLMKSYLYQILLGVVYCHSHRVLHRDLKPQNLLINSKGCIKLADFGLGRAFGVPVRVYTHEVVTLWYRAPEVLLGSTRYSCPLDIWSTGTIFAEMWLRRPLFQGDSEIDELFRIFRILGTPDDDIWPGVSSLPEFKSS-FPKWSKQSYDTFVPNMSESGIDLLSKMLIYDPANRISGKRALSHPYF Thecamonas_adhaerens_GI_196010283 FDKLNRIGEGSYGVVYRARDLDSKEIVAIKKIRMENERDGIPVSSLREITLLVNLKHINIVNLKDVVVGLDSIFLVMEYCEQDLSSLLYNMKAPFTEPQVKCLSLQLIHGVQYLHHNFVIHRDLKVSNLLLTDKGILKVADFGLARNYGLPAAPMTPTIVSLWYRAPEVLLGCTKHTLAVDMWSVGCIIAELFDHNVFLKGKSEKDQLDLMCQMLGTPNEAIWEDIRDMPLYGKIILRQQPYNNLKHKFSWLSAAGLNLLNSLLTYDPGRRITADETLKLSYF Thecamonas_adhaerens_GI_196013334 FEWLNRIEEGTYGVVYRAKDLKSDEVVALKRLKMEKEREGFPITSLREINTLLKADHPNIVHVREIVVGMDKIYIVMEYVEHDLKTLMESMSQPFSISEVKCLMKQLLSAVQHLHDNWILHRDLKTSNLLLSHQGILKVGDFGLAREYGSPLKVYTSIVVTLWYRCPELLLGVKEYSTAVDMWSVGCIFGEFLVKKPLFPGKSEIDQLNKIFKDLGTPNDQIWSGFSELPVAKKVTFTEQPYNRLRDRFGYLTDQGFDLLNRFLTYDPKKRISAEDALNHEYF Thecamonas_adhaerens_GI_196013348 FHKLEKIGEGTYGKVYKACNKITGQTVALKKIRLDSDKEGVPSTTLREISILRSLNHSFVVRLYDVVHSDQCLYLVFEYLDHDLKHYLDHA-YKIPPALLKSYLYQMLRAISYCHSRRVLHRDLKPQNLLIDSTGTLKLADFGLARIFGLPVRQYTHEVITLWYRAPEILLGSTYYSTPVDIWSIGCIFVEMINRRPLFAGDSEIDQLFRVFRTLGTPDEITWPGVSEMSDYKST-FPKWPSRDLNSVIYSHDEDCVDLIKQMLVYEPNGRISARLALQHPYF Thecamonas_adhaerens_GI_196015356 FEFECKVGRGTYGHVYKAKMKSSGKEYALKLI----EGSGISMSACREIALLREVHHPNVISLQGVFLTNRKVWLLFDFAEHDLWHIIKYHAISLDSKMVKSLLKQILEGIHYLHANWILHRDLKPANILVMERGRVKIADMGFARHYWSPLKPLDPVVVTSWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQERDQLERIFMVMGYPHEKDWEDIKKTPNYAKLAFRKITNCSLAKYMIKQDSKEFILLQKCLTIDPNKRISSEQAIDDAYF Thecamonas_adhaerens_GI_196015366 FDFECKVGRGTYGHVYKAKMKTSGKEYALKLI----EGTGISMSACREIAILREISHTHVISLQGVFLTSRKVWLLLDFAEHDLWHIIKFHSVPIDTKIVKSLLRQILDGIQYLHSNWILHRDLKPANILVMERGRVKIADMGFARHFWAPLKPLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEHDQLDRIFTVMGFPHERDWEDIKIMPEYKRLQFKKPASCSLAKYMIRHDSREFSLLQKFLIADPNKRISAELAMDDAYF ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M20996] TITLE Metazoan_Cyclin; LINK TAXA = Taxa1; DIMENSIONS NCHAR=235; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=? GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 ] [ . . . . . . . . . . . . . . . . . . . . . . . ] Amphimedon_queenslandica_GI_340369567 ----PIHETLKKREAA---ISSIQF-KS--PQLHLRRELVEFITAVSKDLGLSDGTRFLAIRLADQFMDGHNVMEYRLRLMGLTCLLLAAKSEEIDVPSIEMLQHANTSAYSRQEFHTLELYILKYFKWCLSHPSVAHFIDYYLHTSLKENLMKEFTAYFMEVTLRGI-KANSLSRHFLINCKDAAGILPAACKW---------------------------------------- Amphimedon_queenslandica_GI_340370065 ----SKTYTYSQAIYH---IEENPR-SYKYVTARDRDEQVSWFRNITHDLSFSISVFYQSTLLLDTFLSTKKTKREFLQTMAASCYSIATKLVESCVALSHKLVSKYYSGCSVTDVEKMEAFLIQTPDIASALHTIQDYIKKFHRLA--ERSLCHLYKC-AQHVVCNHELMKYRPSMLGLAILGCHLKQL--CDWLSTLLEILQIRGGELSICY--------------------- Amphimedon_queenslandica_GI_340373128 ----EDIKWIFSAEVLEHLTPSRKKGISHEMERRYRREGARFISNTSNTLKLRRDTLATGTVFFHRFYMVQNFADFDKYVVAAACVLLAGKVEETP-KKCKDIVRVAKREKPLEELISFERVLLQTIRFDLQVDHPYGYLLKFAKHMKGEKQVLQMAWTFINDSLCTTLCLQWEPPVVAVALLYLAGKLSKFRSWWRQFVT---VDAHDLESCHQDY------------------ Amphimedon_queenslandica_GI_340373665 ----LSSSNLLVPKERLINTPSRKDGMSRDLEIDMRVTGCHYIQSAGILLKLPQVAMATAQILYHRFYYAKSFVKFKCYYTMMACLFLAAKLEESS-RRLRDVINVFHHFRLRNLIIKHERYILKELGFCVHVQHPHKLIISCLQILELEKNLIQKAWNYMNDSLRTNIFLRYNVQTIACSCIYIATGHLKVPPWWELFD----VNYTDMKTSLE-------------------- Amphimedon_queenslandica_GI_340374274 ----DIYQYMREREVKFK-VSSYLD-HQPLINSSMRSILIDWLVEVQENFELFHETLYLAVKIVDRYLEKKEVKKEYLQLVGATSMLIAAKFEELSPPLVDDFIYLCDDAYQHDELLSMERNILATLEYDVNAPVAYRFLRRLARAAGADMETHTLARYICESTLQEYEFVSDDPSHIAGAAMYLSIRMKGLGGWTPTLQHYSQYEASNLLPMVQRLD-LISRPAGNTSTVRSKY Amphimedon_queenslandica_GI_340376468 ----QLESSLREKSEDLARAKQLHSAELANLMDEMRALRVNYDQKMKKRKKQVAATSSSAVDPDGRFVQVTEIPKNKLQLVGVTAMLIASKYEEMYAPEVADFVYITDSTYSNTEIKAMERNILKTLDYSFGNPLCLHFLRRNSRAGDATPQMHTMAKFLMELCLPDYSMLEYLPSLVAAAALYISNKLYSDGEWTPALRHYSQYTEPDVLPCVGKMSLVLSMHTAKQQAVKNKY Amphimedon_queenslandica_GI_340376480 -------------------AAGTEDKNHEKSGYSPVLEETLFVAKAGLRLRMSEVAIATALQYYHTFQSTMEKNRFDENLVAMACLFLAAKAQEVS-LRLSDLVNTCYHWQLKESVAKMELVLLRALKFEFQLDLPHRYLLHHLLSLSHSQWVTRLSWSLLQDSFHTTLNHIHPPNKMAVAVLYLAVKVSRLYQWWEVMCG---VTEPELQTCEANY------------------ Amphimedon_queenslandica_GI_340377763 ----AETNASFCRKYSDAAISKECQFLTPTEEESVCLYYMKKLFEFCNVFPVPRGVLGTAGAYFKRFYLLTSVMDYHPKEIFLSCAYLAFKIEEYN-VSLDEFVYMLSPQSSSEMILNNELMMLKRLKFHLTIHSPFRPLEGFLIDMKTSIPLRKEADSFLMSSLYSDVLFLYPPSQIALAALYYASTVIEV------------------------------------------- Amphimedon_queenslandica_GI_340378990 ----ASLAVFYIVKGRPRDRPPKTLDIFDLHPLTRDPLIYKFIKTLFHAAQLTSECAIITIIYLERLLQYSELHPCNWKRILLGAILLASKVWDDQAVWNVDYCQILRE-ITVEDMNELERVYLEQIQFNINVAAKMY-AKYY--------------FDLRTLS--EENGLTFEY------------------------------------------------------------ Amphimedon_queenslandica_GI_340379451 ----FKEWLLDKQEIEVWRQKDVSYFSSSEDYQKLMIFFANFIQTLGEQLKLRQQVISTAIIYFRRFYSRHSLGDVDPFLLGPTCLYLASKVEECG-VVPGTL-YIRKSSYKAQLIMECEFLLLEMLDCCLIVYHPYRPLTQYVTDLGQE--LLPTAWKIVNDTYRSDICMLYPPYLIALVAIHMAAVVHKKKAWFAELS----IDMNKIIETNLD------------------- Amphimedon_queenslandica_GI_340379787 ----LWREMRLKDTSQAAPGTELRL-RHPSIMPTMRTILLDWMLEVCEEYRIHRETYYLSLELFDRFMDTQNVQKEQLQLIGVTCLFIASKIEEIYPPKLADFAYVTDGACNSEEIVFMELMICKALKWRLHHCSVNTWVNLYMQL-SYFRPLFEYVMQVLDLCTLDITSRQFCNSILAASALYLVSEKC-----QMHLNLVTGFQLADIHVCVQWLIHEVNINMLEEAQDIIKY Amphimedon_queenslandica_GI_340380250 ----APPRRWYYSREQLSNSPSRADGVDPEKELRYRQDAASLIQDMGPKLNLNVLCMSTAIVYMHRFYMINSFKAFDRVLLATAALFLAAKVEEHP-RKLEHVAKCSYSTKLIDDITYHELVLLQTLGFDVQVKHPHPHVVQCMNLVGVSR-LSQAAFFLAHNSQLTTFCLEHPPTVVACMCIHLTCAWKGLKNWWEYVDS---VTYDKLEGATEN------------------- Amphimedon_queenslandica_GI_340380414 ----YQYVQQIVRSSPSLLSASIYD-AQPDVNEEMVFILLDWIVEVAEMKSFSTKTLHLAISLIQRYMVARKLKRSRLQLLGVTALLLAARWTAVPIITIREAAWLTDNTYRYDEVVCMMGEIVSTLHGEIQKPTVPDYLEMFELLVNADKKSSCLAAYVSESAVLFPDFGRYTAAQIAAGCLLLARVLLEQLPWPSALVEATGLTVPDLYHCTSLLQ-----RRSSNSSLLKYR Homo_sapiens_CABLES1 ----KHKRVLIFPSYMTTVIDYVKPSDLKMNETFKEKLKREMRKLAQEDCGLEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKHEVKHLIDKLEEKLNRRELIAFEFPVLVALEFALHLPEH-EVMPHY-------------------------------------------------------------------------------------------- Homo_sapiens_CABLES2 ----GKHKRVLIFASYMTTVIEYVKPSDLDMNETFRESLKREMRSLSEECSLEPVTVAMAYVYFEKLVLQGKLSKQNRKLCAGACVLLAAKISSDLKSGVTQLIDKLEERFNRRDLIGFEFTVLVALELALYLPEN-QVLPHY-------------------------------------------------------------------------------------------- Homo_sapiens_CyclinA1 ----EIYQYLREAEIRHRPKAHYMK-KQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELKAYLDIPHRPQQAIREKY Homo_sapiens_CyclinA2 ----DIHTYLREMEVKCKPKVGYMK-KQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFHQQPANCKVESLAMFLGELSLIADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLQTYLKAPQHAQQSIREKY Homo_sapiens_CyclinB1 ----DIYAYLRQLEEEQAVRPKYL--LGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLKVMVNQGLTKHMTVKNKY Homo_sapiens_CyclinB2 ----DIYQYLRQLEVLQSINPHFLD--GRDINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQVQPVSRKKLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGEVDVEQHTLAKYLMELTLIDYDMVHYHPSKVAAAASCLSQKVLGQGKWNLKQQYYTGYTENEVLEVMQHMKVKVNENLTKFIAIKNKY Homo_sapiens_CyclinB3 ----EIFSYMKEREEQF-ILTDYMN-RQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLKLLTFSSYDSLKAVYYKY Homo_sapiens_CyclinC ----HYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFG-VVNTRLIAAATSPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQE--LLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKRQWFAELS----VDMEKILEIRVK------------------- Homo_sapiens_CyclinD1 ----RVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLNFLTRFLSRVIKCDPDCLRACAL-------------------- Homo_sapiens_CyclinD2 ----RVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQSSLTELLAKITNTDVDCLKACQE-------------------- Homo_sapiens_CyclinD3 ----RVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLG-CSMTELLAGITGTEVDCLRACQEQI------------------ Homo_sapiens_CyclinE1 ----EVWKIMLNKEKTYLRDQHFLE-QHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQNVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYMQVAY----NVLLIAELLDLCVLDVDCLEFPYGILAASALYH-F-SS-----SELMQKVSGYQWCDIENCVKWMGKLKHFRGVADEDAHNIQ Homo_sapiens_CyclinE2 ----EVWLNMLKKESRYVHDKHFEV-LHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLFLQVDA----KVLLIAQLLDLCILAIDSLEFQYRILTAAALC-HF-TS-----IEVVKKASGLEWDSISECVDWMKSPVKLKTFKKIPMEDRH Homo_sapiens_CyclinF ----SEIVCQLFQASQAVSKQQVFS-VQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVVDYKEVLLTLVPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALLLARLTHGQQPWTTQLWDLTGFSYEDLIPCVLSLY-----RQVSLTAVKQRF Homo_sapiens_CyclinG1 ----SRCQPKVCGLRL---IESAHD-NGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEEVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQ----FERLEAQ-LKACHCRIIFSKAKPSVLALSIIALEIQ--------E-------------------------------------- Homo_sapiens_CyclinG2 ----ERFQPREKGLSL---IEATPE-NDNTLCPGLRNAKVEDLRSLANFFGSCTETFVLAVNILDRFLALMKVKPKHLSCIGVCSFLLAARIVEEDIPSTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFLHLYHTII-----LDKLEAQ-LKACNCRLIFSKAKPSVLALCLLNLEVE--------D-------------------------------------- Homo_sapiens_CyclinH ----ANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFN-VSSPQFVGNLREEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTILELRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGI------------------------------------------- Homo_sapiens_CyclinI ----KAITREAQMWKV---NVRKMP-SNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFLHIFHAIAVSTRPLAVLTKQ-LLHCMACNQLLQFRGSMLALAMVSLEMEKL--PDWLF-------------------------------------- Homo_sapiens_CyclinI2 ----CHLQLAQDREAR---LWRGGK-PQDEICDAFE-EVVLWLLRLQNTFYFSQSTFNLALTIFGRLLISVKVKEKYLHCATITSLRLAAKVNEEEIPQVKDFTKHYGSDYSPNELLRMELAILDRLHWDLYIGTPLDFLTIFHALVVLSWPVASLTRQ-LQHCMAGHQLLQFKGSTLALVIITLELERL--PGWCA-------------------------------------- Homo_sapiens_CyclinJ ----DIHQALRYKELK---LPSYKG-QS--PQLSLRRYFADLIAIVSNRFTLCPSARHLAVYLLDLFMDRYDISIQQLHLVALSCLLLASKFEEKEVPKLEQLNSLTNLVLTKQNLLHMELLLLETFQWNLCLPTAAHFIEYYLSEAVHDLHMAKYADYFLEVSLQDYAFLNYAPSLVAAACVASSRIILRLPTWPTRLHRLTAYSWDFLVQCIERL------------------ Homo_sapiens_CyclinJL ----DVHCTLREKELK---LPTFRA-HS--PLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTSKQLYTVAVSCLLLANGVEDREVPKLEQILSSQNFTLTKKELLSTELLLLEAFSWNLCLPTPAHFLDYYLLASVSHHCLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLPYWTRDLQRISSYSLEHLSTCIEIL------------------ Homo_sapiens_CyclinK ----HTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETP-KKCKDIIKTARSDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFRRWWEQFVD---VPVDVLEDCHQDYQQSSEPSQPQQKDPQQPA Homo_sapiens_CyclinL1 ----LTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAP-RRIRDVINVFHHINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPHWFLLFG----TTEEEIQECIERY------------------ Homo_sapiens_CyclinL2 ----ITLENCLLPDDKLRFTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAP-RRIRDVINVFHRVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNLVQTSWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPHWFLLFG----ATEEEIQECLKQY------------------ Homo_sapiens_CyclinO ----SCYAFRKAQE-SHFHPREALA-RQPQVTAESRCKLLSWLIPVHRQFGLSFESLCLTVNTLDRFLTTTPVAADCFQLLGVTSLLIACKQVEVHPPRVKQLLALCCGAFSRQQLCNLECIVLHKLHFTLGAPTISFFLEHFTHA-RVALEAQALARGVAELSLADYAFTSYSPSLLAICCLALADRMLRVS--RPVDLRLGDHPEAALEDCMGKL------------------ Homo_sapiens_CyclinT1 ----NNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQP-KKLEHVIKVAHTLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASK-LAQTSYFMATNSLLTTFSLQYTPPVVACVCIHLACKWSNWKHWWEYVDT---VTLELLDETHEQ------------------- Homo_sapiens_CyclinT2 ----GASSRWFFTREQLENTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNKNIISSTALFLAAKVEEQA-RKLEHVIKVAHALQQTQELVILETIMLQTLGFEITIEHPHTDVVKCTQLVRASK-LAQTSYFMATNSLLTTFCLQYKPTVIACVCIHLACKWSNWKHWWEYVDT---VTLELLDETHEQ------------------- Homo_sapiens_CyclinY ----CVALAIYYHIKNRDPDGRMLLDIFDLHPLSKSEQIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEICPANWKRIVLGAILLASKVWDDQAVWNVDYCQILKD-ITVEDMNELERQFLELLQFNINVPSSVY-AKYYF------------DLRSLAEA--NNLSFPLLS------------------------------------------------------------ Homo_sapiens_CyclinYL ----FLSKSQTDVREKRKSNHLNHCDLSNPHKEQREKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEICPTNWKRIVLGAILLASKVWDDQAVWNVDYCQILKD-ITVEDMNEMERHFLELLQFNINVPASVY-AKYYF------------DL--RSLA--DDNNLNFAP------------------------------------------------------------ Homo_sapiens_Fam58A ------------PEGGGGGPAARGPEGQPAPEARVHFRVARFIMEAGVKLGMRSIPIATACTIYHKFFCETNLDAYDPYLIAMSSIYLAGKVEEQH-LRTRDIINVSNRWELRDSIVQCELLMLRVLRFQVSFQHPHKYLLHYLVSLQNHSWVAVTAWALLRDSYHGALCLRFQAQHIAVAVLYLALQVYGVKPWWQVFND---LTKPIIDNVSDQY------------------ Homo_sapiens_Fam58B --------MEDAGEEAGEDAGEDAREGAAAPAARVHFRVARFIMEAGVKLGMQSIPIATACTIYPKFFCETILDAFDPYLIAMSSIYLAGKVEEQP-LWAHDIISVSNRWELRDSIVQRELLMLRVLRFQVSFQHPHKYLLYYLVSLKNHSWVAVTAWALLRDSYHGGLCLRFQAQHIAVVVLYLALQVYGVKLWWQAFSD---LTKPIIDTVSDQY------------------ Monosiga_brevicollis_GI_167517989 ------------------------R-KQRDINHTMRSILIDWLIEVTEEYKLTLQTFFVTVGYVDRFLSEMAVQRSKLQLVGVTCMLLACKYEEIYPPTIDDFVYITDKTYSRPQVMKMEHVILKVLRFDMGSCTPLTFLYYFLNAIPHHDDTKWLAQYLCELSAYGRRSLGQRPSTTAAAAIVIALHTFELHPLPPALVSVIRQGPEELQAAVNTLEIFSVYPNLQHEAIKEKY Monosiga_brevicollis_GI_167522783 ----CMAFSREAFARGAAPVRRGGL-RQPDREGKMRFILMDWLIEVADLKTFGGETLFVAMDLVDRFLQHCRITRKTLQLLGIACMVMAARYLEEGVITIREAAWLTDSMYSYDQIVRTIGQVLVDVSGNVIRPTTFHYLNLLLQIGGATPAVFLLGQHMAEALILTIPLTEFPPAKLAAAMACCTFALAGVQPWSSTMERWSGLELRTIYDSA--------------------- Monosiga_brevicollis_GI_167523717 ----DIYNYMREMEVRLCCDPAYLQ-SQPEVNERMRAILIDWLVEVHYRFELLQETLYLTVDVLDRFLSSERTSRSQLQLVGVTAMLIASKYEEMYPPEVGDFVYISDNAYRREQILAMEQTMLRVLDFNLGKPLPLHFLRRDSRAGHADGTMHTFAKYFMELTLCSPRFLGYKPSQVAAAATYISREVVGEQLWTPTIEFFADYTLTDIMPVILDMAILRESPTAKQQAVRTKF Monosiga_brevicollis_GI_167524110 ---------------------------------------------IYHGITPSANALYFAIAYLQRYAVTTTLMEHHPDLICLTCWLLAVKASEAK-VPLHCLVAVAQRKDVEDQVRQLESSLAQKLNYEFYVSLPSRAMRAILIELQGPAPDEKSIMAALLNLWASPAQLQMAPVQLCLAALG--------------------------------------------------- Monosiga_brevicollis_GI_167526102 ----EVHRNMRVQESQ---LQLAQY-CG--PLADLRPRCVQRIHRLARAFRFHRLTRDAAIFYFDRMLFLFHMHESHLELAVQTAFLMAAKCQEAEVPTHHDLHRAGCAVVPTAHLKAFEASYLERVDWILTSVTPSDFLDYYARFSISDCLTLDLADQVLQEASMANHVATFLPSHRAAAAITTARLIVDIPAWSPTLQAVSGLTWREISPCVDAMQ----------------- Monosiga_brevicollis_GI_167526156 ----FPCLDSDLPRFDLANTPSRRRGIPAELELRLRIAGCELIQKTGMLLGCKQVVMACAQMLLQRAYCRLDISRHSLQWVGLACLFLAAKTEEDH-QRLRSILLVGRVHELKNNVIKSERRVLKELGFCVHLKHPHKDV-------------AQLAWNYMNDALRSDVFLRFEVAVIACACIDLATRKLDIDLWFQSFG----VHPDDFEQCATQY------------------ Nematostella_vectensis_GI_156350442 ----RVLTNLLACEERYLPSCNYFKIVQTEVEPHMRKLVATWMLEVCEEERCEEEVFALSMNYLDRILSLLPVKKFQLQLLGAVCMFIASKMKETSPLTAEKLCIYTDNSITTEELLDWELLVLGKLKWDVSAVTPHDFLDQIFSRLPLDRSTRKHASTFIALCCTDDKFLLYTPSMLAAASVCAAFTGLGIRSWASLLHAITNIEPECLRSC---------------------- Nematostella_vectensis_GI_156359300 ----QIMRYAMALENKYQLPENFLE-KQEEVSHQARAVLIDWLIEVHLFYNFPQDCLYLIVALVDRYMSLRTVPVAHFQLLGMACLLVACKYEDRFVPTREELVAMADQAFDQSELMHMETRLLTCLEFDLAQPLPTFFLRPIARASAIDLETYVVSKFIMEAAMLDAIMVTFKPSIIAATAFFMA------------------------------------------------- Nematostella_vectensis_GI_156359932 ----HCNQWMLDVDEIMIGRQQDLQFLTEVEYQKVHIFYSNFMQSLGEHLDLRQQVIATATVFFKRFYSKNSLKSIDPLLIAPTCVYLASKVEECG-AINNKLISASSVPYRMNQVLECEFYLLEMLDCCLIIYHPYRPLTQYVSDLGME--ILPTAWRIINDSLRTDIFLIYPPYLIALAAIHMACVIQQKKQWFAELS----VDMDQIVETHHR------------------- Nematostella_vectensis_GI_156363375 SPLPELWSYMLEKDRKYTKDHLYLR-QHPHLQPRMRAILLDWLIEVCEVYRLHRETYFLAVDFVDRYLSVKDIPKQRLQLVGTTALFIAAKLEEIYPPKLSEFAYVTDGACKEDEILQQELLMLQDLNWKLCPITSNTWLNIYMQLHSCEALHFVIVSQLLDICSLDIESLQFSYSVLAAAAMYHV---I-----PVSIEEITCHKREDLSPCIQWM------------------ Nematostella_vectensis_GI_156364707 ----EIMRFLRAMEEHYSVSPTYMN-NQQEVNEKMRAILLDWLVQVHLKFRLLQETLYITMSIIDRFLAVHQVSKRELQLVGVGAMLLASKYEEMFAPEIGDFVYITDHAYTKKQIRQMESLIFRKLDFSLGKPLCLHFLRRNSKAGAVGAEEHTMAKYLMELTLIDYQSIKFLPSEIAAASLSLAMRVMGKSEWTPTLEHYSGYSEKKLSTCMQRLQLVLGARDSKQKAVYNKY Nematostella_vectensis_GI_156365799 ----AEFLTQFLQKSKALNSHKLFG-FQTELNNTMRYILVDWLVEVALMKDFSSQIVHIAVHCVDQYLMKRKVQRSELQLLGITCILIAARFQGKDIVTIREASWLTDDTYSYEEVVRMMGEVMSCLRGEV-------------------------------------------------------------------------------------------------------- Nematostella_vectensis_GI_156365937 ----ITLENCILSPDKLTETPSVKDGLDKNVEEDLRIIGCEFIQTSGLLLKLPQVAMATGQVLFQRFYYTKSFVKHDVEVGSCTCYYCTSKRNGQI-KATKHRIVSVRGFNRKNQVVKAERRVLKELGFCVHVKHPHKIIITYLQILECETNLAQLAWNHMNDSLRTSAFVRFAPETIACACIFLASRLLKIPPWYELFD----------------------------------- Nematostella_vectensis_GI_156375154 ----DIFKYLKQAELNNRAKPGYMR-KQPDINNSMRAILVDWLVEVAEEYKLLPQTLYLTVNYIDRFLSAMSVLRGKLQLVGTACMLLASKFEEIYPPEVSEFVYITDDTYTAKQVLKMEQLVLKVLTFDLSVPTILNFLERFIKATNVPPKVEALARYLCEISLLSEPFLKYLPSTIAASAIVLSLHTLGLSYWNNTLSHYTGFELHDLQTCIQDLRSFAYAPNHPQQATREKY Nematostella_vectensis_GI_156380901 --------------------------KQKELTISMRAILVDWLVEVQESFELYHETLYLGVRVLDNYLMRSYVERENLQLVGAVSLYIACKVEERHPPCLDDFLYICDDAYQQKAFVAMEKKILNSLEFNINMPIPYRFLRRFAKVASADVKTLTLSRFILETTLHHYKFIVHKPSFLAAACLRLALRMKGCDDWTPTVVHYTGYSVAQLDGCVIELEMISEPPKQNLMTVRNKY Nematostella_vectensis_GI_156381346 ----NVNSAYKSRHSEAYPDKKNVKYLTVEEEKKLVEYYELVIVEVSAKFPVPRSVTATAITYLKRFYVKTSVMDHPPKEMFLVCLFMACKVEEYN-ISVENFVQILPREKVMDFILAHELLLMERLDFHLTIHHPFRPMEGFLIDIKYGKVWRIKAEEFLLRAMRTDVAFHFSPSQIALAALSVGST----------------------------------------------- Nematostella_vectensis_GI_156389378 ----SSDERWYFTKEQLQNSPSRRMGMDAERELSYRQQAATLIQDMGQRLSVSQLTINTSIVYMHRFYMCHPFQKFHRHAMAPCCLFLSAKVEEQP-RKLEHVIRVAHALQQAQDLIENESILLQTLGFEVTVHHPHTYVVKGIQLVRASK-LGQASYFMATNSLLTTLCLQFKPPVVACACIHLACKWCNYKYWWQYINT---VTKKLLDEAQE-------------------- Nematostella_vectensis_GI_156397054 --------------------ERAARRKATYAYLKEHFKVTQFIMESGAKLSLPQNAMSSACVLYHQFWKGCDPKDFDPYLIGMTAIYLASKAEECP-CKVRDVINVCYRWELRESVVNCELLMLRVLGFRVSYDNPHKYLLHYLKVLQDGMWVPQISWSYLLDSHHIPLCLEYPPAHVAVALLHFAVECVGLRPWWKALCD---VTPELIQSTEDDY------------------ Nematostella_vectensis_GI_156405242 ---------WLFTHDGLNRTPSRLDGIDYATECRYRREGTRFIMECGNKMGLRYDTMATGAVYFHRFYMIQSFKNFPRWVTGAACLFLAGKVEETP-KKCRDIIKTANSPDPKEEVMIYERILLQTIKFDLQVEHPYPCLLKLGKGLKGDRALVQMAWTFINDSLSTTLCLKHRSEVIANAMLALAAKLNN-------------------------------------------- Nematostella_vectensis_GI_156406586 ----KCVSLAVYYHIKNRDPEVRTVDIFDLHPLMNDPHIYKFIKTLFHAAQLTAECAIITLVYLERLLTYAEVYPGNWKRILLGAILLSSKVWDDQAVWNVDYCQILKD-VTVEDMNELERAFLEFLQFNINVPSSVY-AKYYF------------DLRSLADA--NDLMFPLLS------------------------------------------------------------ Nematostella_vectensis_GI_156407073 ----DIHEVLREKEAR---IPNFMA-AS--PQLKIRRYLVDWLAVIGEKLGSSHGVVHLAIYYMDFFMDKFIIQESQLHLLALTALLLAAKFDENEIPDISTLNKFVNNTYQHAEYHQMELLLLEFFNWNIDLPTPVQFLEYYLAKATIDYKLRKYVYYFLEISFQDHTFLSFSPSLITSSCIAASRICLNLPSWTNELSKVTNYDWDKIAHCTEIM------------------ Nematostella_vectensis_GI_156408249 -----------------------------------RDKSVCILLHINRHCGFQPETFALAVNLLDRFLSVVKANPKYLPCISISCMFLAAKMVEEDIPTAGNLIGVSGLSCTPSDLLRMERIILDKLGWNLSAVTPLQLLQVFHALCV----LHHITLK-LEELLCNHKFTFFKPSTLALSLLSCEISSL--NVW---------------------------------------- Salpingoeca_rosetta_GI_326426811 ----KVMTYLRHLEKKFRPHAGYMG-RQRDINHNMRSILVDWLVEVTEEYRLQLQTLYIAVGYIDRFLSNMAVQRSKLQLVGVTCMLLAAKYEEIYPPSVNEFVYITDNTYRREQVLKMEHVVLKVLRFDMGACTALTFLVRFIHAASATPPSHCLALYLAELSLLGNKFIQYLPSVKAAAAICLSQHTFARPVWTPTFERYCRLSPEEVQPCLNDMEAMTSAPHLEYQAIREKY Salpingoeca_rosetta_GI_326428978 ----PIFEYMRELEVRLHVPANYFK-IQTEINARMRDVLVDWLAEVHHRFELIQETFHLTVHLLDRYLSKEPVTRDDVQLVGITAMMVAAKYEEMYPPELGDYVYITDKAYSEDRILAMERKLLRVLDFSLGKPLPLHFLRRNSKAGHADATMHSMGKYMIELSLGSHAMLKYVPSQLAAAATYISREIVGEELWNPTLEHYAKYSLEDIAPVVHDMAVLKHSTVSRLQAIRNKF Salpingoeca_rosetta_GI_326429298 -----------LTKEQVADTPSRKDGIDADREARYRRECIHFIKQLAIRFQLSPRVYMTAMVIFHRFFLTHSFKDLSRLNFAAACLFIGGKIEEQP-KRMQDFLPVVHEARLRFILQGCERAVLQTIDFELSYDHPLEPLLQYA------------------------------KTEIAAALLELASRKSSSRPWFE-------------------------------------- Salpingoeca_rosetta_GI_326435281 ----AIYAKNLQREE---KYLLNPR-PSRGINLAMRTVVIDWMIEIQVSFKLRDETLFCAVDILDRYLAARPEQRHDYQCCGATSLWIASKFLEVLPPELADFEYVCAGLYPRQAFIDKELTMLTALRFYVMNVTPLDFISVYAIVLQLSLEGMALAEYLITLPLQEQRFYGLRPSVRGAAAVHIASKTCDGPGWSEDHSALFKLDHRHIMLVAQ-------------------- Salpingoeca_rosetta_GI_326437558 ----QYYRVLEQRLASCEVSINALK-MQPCMPPRLRARVFHWLADVCDRARMTLDTLFFAITYFDTYCSVRAVTVANMQLLACACLRLAAKIEETRVPSLRLLSRLTDGACQPTGIAQFELDLAAVLKWRLIRSTPLHWTRFFIGVA---LGSSAPSCQVLQLAMSDAWALRFDARQMAAAAVLLSA-TR-----PIDILAVTGLDKCALRTCLRWVRAVGFCHDGSSCGASGLK Salpingoeca_rosetta_GI_326437566 ----VALALSYVVEDGHKQDNPRLFSEKFKRHPITDRRIYKFMFQLFNSAQLTAECAIITLVYVNRLIAYTSLHASTWKRVVLGAILLASKVWDDQAVWNVDFCSMLPS-VAVEDMNDLERTFLEMLDFNIDVDSCV------Y------------AKYYFELR--ALAEKFEFP------------------------------------------------------------ Salpingoeca_rosetta_GI_326437823 ----------SLPRYDLQNTPSRAHGVSEELETRLRVAGCEIIQSAGILLNCNQVVMACAQILYQRFYYRQSFATQRFEVTAMGCLFLASKVEEEQ-QRLRILMNVCRHHNLKHRVIKAERLVLKELGFCVHLDHPHKLIISMQSVLSLEDNLAQRAWNYMNDGLRTTVFVRYTTATIACACLDLACTDVGIDQWYELFG----LMGFAPAPMGAAA------------------ Salpingoeca_rosetta_GI_326437989 ----FRETVELGMEKLRLRSDAPPP-AQPDSQGKMRFILVDWLLEVASLKMYSIDTLHCAVDMVDRYLATRTITRRTLQLLGITCMVIAARFLEQDVVTIREAAWLTENTYDYEDVVQMVAAVLAVADGHVRRPSPNDYITIFAELSNVPVHIRCFMDYVSESCLLHQPTLTHAPAALGAAIYFVSMHLVGCSAWPSSLTSNSDLRVSH---EI--------------------- Thecamonas_adhaerens_GI_195998946 ----LHNQFFQKLKDDDSRHIRTKDLPSVEELDHLCTFYEFELMDLCRRF----PMPATAAVYMKRFYLVCSVMDYHPCDIMLACVYLATKVDEYN-ISIDKFLTMVPEERAKSRTLGFELLVMEKLKFHLTIHCPYRPVEGLLINIMVIADLRRHIDKFLSKILYCQAMLIYPPSQVGEIALFPSQ------------------------------------------------ Thecamonas_adhaerens_GI_195999522 ----TAYVRKMVESCRNINIKLVNR-IQLELNDRMRYILIDWLVEVAEMKEFSSEMLCNAIDLVDRYLEINPIPRSNLQLLGISCMVIASRYHCVDIMTIREAAWLTDNTYKYDEVVRMIGEVFAAVNGEIRTPSAFDYLKIFCTISEVSQKCTYLASFILELSWLFLENSRYKSAVKAAASLLLARVLMGNLPWTEELKSYTGLSLEDLSSCVLHLK-----KCLAEKPPKDYY Thecamonas_adhaerens_GI_196000815 -------GEKSKVVMPPVVKISAQQLIEDKDHWPEYLKIGKFIAESGIKLKLGSVVIARAATIYHRFYFLCDISQFDRYLVAVTCLYLASKVEDTP-RRARDVITTSYKWQLRDSVVNFELFMLRMLKFDVSSELPHKYLLHYLKSLQDSNWINQLCWQLLQDTSLLPFILLYPPSVIATAVIYLAVKCNNIKPWWNVFSN---LNEEGLQQCYKEY------------------ Thecamonas_adhaerens_GI_196001479 ----RVLQNLLKLEENYLPNRDYFTNVQREIKPFMRCMVTNWMLDVCHGENCNDKVFPLAVNYLDRFLSMVSIRKIRLQLVGSVCLFLASKLKDRIPLTAEKLCSWTDYSVTCQELLDWELLLLEKLKWDLGSVTPLDFLDQILYRLSFEKDYKKHAYTLIALCCTDFQLCTNPPSMIAGGCILCALA----NDNNRIVQKITSIEPDYLICC---------------------- Thecamonas_adhaerens_GI_196002535 ----DIYKNMLKQEKRCTLDPDYMT-GQPVITKGMRAILLDWLVDVHLRYNFHPESLYLTTYIIDRYLQTTQVNRKKLQLVGIAAFYIAIKYEEIFLASTDDLLYLTENSYEINEFIQMEAKILKALDFSLSRPTSIHFLRRISKAASADIEQHTFARYLTEIALIEYSLLSYLPSQIAAAASLISLKIFD-KSWTPTLQYYSSYSEDSLKPVARQI------------------ Thecamonas_adhaerens_GI_196003236 ----EVWQVMIENDNNFKRSPDCFD-RHPNLVPNMRGILLDWMMEVCESFKMQRETFYMAMDYLDRYLSLSNILKQKLQLIGTTCLFIAAKIEEIQPPQVSEFAYVTDSACSEDDIIKLELQLLQTLEFQLSPVTVTSWLNVYVQLFNIKLSEMLYAIRLIDLCILDSWCLMHSYRSIAASAFYLIA-PS-----KQLAIDCTGYLWENLTSCISWM------------------ Thecamonas_adhaerens_GI_196003740 ----IIFENMKQREAQL-VVNDYLE-RQNDITEQMRMILIDWLCEVQQNFELFHETLYLAVKIVDRFLSARVVSRDALQLIGATAMLMSSKIEERYPPLVDDFVYICDDAYSRQAVLDMERDICYALDFDLNIPIPYRFLRRYGKVASLSMENLTLARYILELTLQEYQFVTFKPSMLAAGCLCLALKMKNCGEWTQTLVHYSGYEESELNELVQKLAMIAKPAPENCKVVKTKY Thecamonas_adhaerens_GI_196005765 ----DIHSYLRKAEYFHRPKYDYME-RQCDVNGTMRSILVDWLVEVSEEYKLRERTLYLAISYIDRFLSAMSVRRSKLQLVGTAALFIAAKFQEIYPPDCAEFAYITDDTYNIKQVLKMESLMLKVLSFNLSSPTAVDFLERYGSEAGLDSEIRELSMYLTELTLKDYGFLQFMPSLIAVSAVSLALHTFKLKYWPQELSTYTNYQWQQVSPCLNRIEAFRLAHTQPQRAVVEKY Thecamonas_adhaerens_GI_196007260 ----LSLENTIYPDEKLQETPSQLDGLSKEMETNLRIAGCEYIQAAGILLKLPQVAMATAQVLYQRYYYSKSFVKYNYEICAMACIFLAAKIEEHP-RRIRDVVNVFYHFHKKSEVIKAERRVLKELGFCVHVKHPHKCIVTYLKILECNDNLIQKAWNYMNDSLRTDVFMRYTPETIACACIYLSARQLGIPPWYEVF------------------------------------ Thecamonas_adhaerens_GI_196007480 ---------WYFCSNEIVNSPSRSDGIEITAECRYRREGARFIMDVGNRMNLRYETVATGIVFYHRFYMMHSFKTINRLIGAAACLYLAGKAEETP-KKCRDLVKAVRTDDPKEEIISHERLLLQTIKFDLCVQHPYKYIVKFAKNLKDDRAVVQMAWNFVNDSLSTTLCLQWKPQVVAVSLLHLAAKLSKYKSWWQHFLE---INSDVLEDCLQDY------------------ Thecamonas_adhaerens_GI_196011367 ----HYSQWVLDRQEILAGREEDLSYLSEDEIFKIHMFFANFIRHLGDLLKLRQQVIATAIVYFKRFYSRNSLKSIAPLLLAPTCILLASKAEECG-IITGRFINACTNPYKMPVILECEFFLLELLDCSLIVFHPYRPLLQFVEDFEKK--LLPCAWRAINDSYNTDICLMYPPYIIALACLHTACIIQSITQWFAELS---------------L------------------- Thecamonas_adhaerens_GI_196012973 ------------------------------ITPTQREALISSMINLSRKHNIKRDTLFMAVNYLDRFLKVVTVTEDCFELVGLTCMMIACKVEECQPPKMEEFLTSCTHYYKKAEMKRLEIIILNYIDFRLSPPIAPHFLEYIIHFHQHYIELVNIANQVLLKILPTYRFNHIKSSILAASAFEY-------------------------------------------------- Thecamonas_adhaerens_GI_196013209 ----CTLKCFICFALRMYRHDPPRLKDIFELHPLMRPHVYKFFKTLFSSAQLTAECAIISLIYVERLMEYAEIHPSNWRRVVLGAILLASKVWDDQAVWNIDYCQILKD-TTVEDMNALEREILQLIMFNINVPSSIY-AKYYF------------------------------------------------------------------------------------------- Thecamonas_adhaerens_GI_196013340 ----FAVTNFYFSDTELQNTPSRRNDISVATELYYRQTCALCIQELGMKLGANQLTINTALVYMHRFYMFHSLASYNLKNIAACAIFLASKSEEHP-NKLNKVITAAYELKLSQDLVDNEYAMFFTTGFDIEIMHPHTHVIKCLHG----------------------------------------------------------------------------------------- ; END; BEGIN TREES; TITLE Figure_1_Metazoan_CDK_BI; LINK TAXA = Taxa2; TRANSLATE 1 Amphimedon_queenslandica_GI_340369066, 2 Amphimedon_queenslandica_GI_340369314, 3 Amphimedon_queenslandica_GI_340371337, 4 Amphimedon_queenslandica_GI_340373367, 5 Amphimedon_queenslandica_GI_340377126, 6 Amphimedon_queenslandica_GI_340379293, 7 Amphimedon_queenslandica_GI_340380476, 8 Amphimedon_queenslandica_GI_340381019, 9 Amphimedon_queenslandica_GI_340381980, 10 Amphimedon_queenslandica_GI_340383363, 11 Amphimedon_queenslandica_GI_340384408, 12 Homo_sapiens_CDK1, 13 Homo_sapiens_CDK10, 14 Homo_sapiens_CDK11B, 15 Homo_sapiens_CDK12, 16 Homo_sapiens_CDK13, 17 Homo_sapiens_CDK14, 18 Homo_sapiens_CDK15, 19 Homo_sapiens_CDK16, 20 Homo_sapiens_CDK17, 21 Homo_sapiens_CDK18, 22 Homo_sapiens_CDK19, 23 Homo_sapiens_CDK2, 24 Homo_sapiens_CDK20, 25 Homo_sapiens_CDK3, 26 Homo_sapiens_CDK4, 27 Homo_sapiens_CDK5, 28 Homo_sapiens_CDK6, 29 Homo_sapiens_CDK7, 30 Homo_sapiens_CDK8, 31 Homo_sapiens_CDK9, 32 Homo_sapiens_CDKL1, 33 Homo_sapiens_GSK3alpha, 34 Homo_sapiens_MAK, 35 Monosiga_brevicollis_GI_167516186, 36 Monosiga_brevicollis_GI_167516210, 37 Monosiga_brevicollis_GI_167516962, 38 Monosiga_brevicollis_GI_167517533, 39 Monosiga_brevicollis_GI_167522415, 40 Monosiga_brevicollis_GI_167522771, 41 Monosiga_brevicollis_GI_167525607, 42 Monosiga_brevicollis_GI_167525918, 43 Monosiga_brevicollis_GI_167536606, 44 Monosiga_brevicollis_GI_167538010, 45 Nematostella_vectensis_GI_156349526, 46 Nematostella_vectensis_GI_156360882, 47 Nematostella_vectensis_GI_156365870, 48 Nematostella_vectensis_GI_156374066, 49 Nematostella_vectensis_GI_156383566, 50 Nematostella_vectensis_GI_156385093, 51 Nematostella_vectensis_GI_156391793, 52 Nematostella_vectensis_GI_156392090, 53 Nematostella_vectensis_GI_156398520, 54 Nematostella_vectensis_GI_156403969, 55 Nematostella_vectensis_GI_156407302, 56 Nematostella_vectensis_GI_156408568, 57 Salpingoeca_rosetta_GI_326426444, 58 Salpingoeca_rosetta_GI_326430756, 59 Salpingoeca_rosetta_GI_326431660, 60 Salpingoeca_rosetta_GI_326434528, 61 Salpingoeca_rosetta_GI_326436991, 62 Salpingoeca_rosetta_GI_326436992, 63 Thecamonas_adhaerens_GI_195996637, 64 Thecamonas_adhaerens_GI_195996663, 65 Thecamonas_adhaerens_GI_195998898, 66 Thecamonas_adhaerens_GI_195999760, 67 Thecamonas_adhaerens_GI_196000717, 68 Thecamonas_adhaerens_GI_196001193, 69 Thecamonas_adhaerens_GI_196001971, 70 Thecamonas_adhaerens_GI_196002669, 71 Thecamonas_adhaerens_GI_196003954, 72 Thecamonas_adhaerens_GI_196010283, 73 Thecamonas_adhaerens_GI_196013334, 74 Thecamonas_adhaerens_GI_196013348, 75 Thecamonas_adhaerens_GI_196015356, 76 Thecamonas_adhaerens_GI_196015366; TREE Fig._1_BI = [&R] ((34:0.884985,(32:0.798028,33:0.950484)1:0.185902)1:0.009333079,((64:0.418034,(36:0.435605,58:0.40015)0.88:0.100133,(9:0.215464,(24:0.240841,56:0.126784)0.86:0.050155)0.97:0.056692)1:0.455657,(((43:0.517355,60:0.337341)1:0.233851,(4:0.32326,(46:0.143944,(29:0.113972,69:0.215394)0.85:0.058487)0.72:0.054436)1:0.200065)1:0.241482,(((42:0.652534,(22:0.034788,(30:0.026951,(7:0.131684,(75:0.091477,76:0.109547)1:0.12471)0.71:0.043438)0.51:0.023983)1:0.366767)1:0.564746,((41:1.38146,((65:0.209454,(5:0.244114,(31:0.108352,47:0.164341)0.96:0.042787)0.94:0.080833)1:0.359902,(2:0.236986,((35:0.658776,70:0.129256)1:0.150746,(53:0.146011,(15:0.048272,16:0.044807)1:0.083132)0.65:0.05151)1:0.117607)1:0.242149)0.84:0.102873)1:0.178476,((44:0.43204,(10:0.140199,(14:0.093003,(49:0.14577,73:0.098695)1:0.051903)1:0.050316)0.69:0.075451)1:0.226302,((37:0.399687,59:0.383249)1:0.15053,(3:0.315283,(72:0.290019,(13:0.205729,45:0.205653):0.054392)0.93:0.058321)1:0.052691)0.54:0.123401)1:0.200727)1:0.146128)0.95:0.139239,(((26:0.223444,28:0.177226)1:0.130299,(48:0.28413,66:0.507538)1:0.130139)1:0.515815,((61:0.440124,((38:0.172746,62:0.165788)1:0.10191,((8:0.259515,(51:0.242594,(12:0.148714,71:0.228961)0.84:0.056035)0.65:0.029174)1:0.133613,(74:0.340113,(6:0.261146,(50:0.160809,(23:0.111417,25:0.1806)1:0.066248)0.73:0.028338)0.55:0.040519)1:0.081871)0.61:0.039221)0.94:0.085562)0.93:0.066392,(((40:0.253062,57:0.634576)1:0.207506,(67:0.390266,(11:0.250841,(27:0.117293,55:0.094037)0.87:0.045394)0.69:0.057487)1:0.136324)0.93:0.084708,((39:0.341851,(68:0.275368,(52:0.296175,(17:0.135626,18:0.230683)1:0.104896)0.62:0.052245)1:0.224095)0.64:0.056675,(1:0.230166,(63:0.212665,(19:0.087799,(21:0.145346,(20:0.055839,54:0.195437)0.94:0.034622)0.89:0.021192)1:0.058433)1:0.069562)1:0.06101)1:0.291085)1:0.106437)0.92:0.094629)1:0.182388)0.96:0.101262)0.86:0.077816)0.54:0.22710492); END; BEGIN TREES; TITLE Figure_3_Metazoan_Cyclin_BI; LINK TAXA = Taxa1; TRANSLATE 1 Amphimedon_queenslandica_GI_340369567, 2 Amphimedon_queenslandica_GI_340370065, 3 Amphimedon_queenslandica_GI_340373128, 4 Amphimedon_queenslandica_GI_340373665, 5 Amphimedon_queenslandica_GI_340374274, 6 Amphimedon_queenslandica_GI_340376468, 7 Amphimedon_queenslandica_GI_340376480, 8 Amphimedon_queenslandica_GI_340377763, 9 Amphimedon_queenslandica_GI_340378990, 10 Amphimedon_queenslandica_GI_340379451, 11 Amphimedon_queenslandica_GI_340379787, 12 Amphimedon_queenslandica_GI_340380250, 13 Amphimedon_queenslandica_GI_340380414, 14 Homo_sapiens_CABLES1, 15 Homo_sapiens_CABLES2, 16 Homo_sapiens_CyclinA1, 17 Homo_sapiens_CyclinA2, 18 Homo_sapiens_CyclinB1, 19 Homo_sapiens_CyclinB2, 20 Homo_sapiens_CyclinB3, 21 Homo_sapiens_CyclinC, 22 Homo_sapiens_CyclinD1, 23 Homo_sapiens_CyclinD2, 24 Homo_sapiens_CyclinD3, 25 Homo_sapiens_CyclinE1, 26 Homo_sapiens_CyclinE2, 27 Homo_sapiens_CyclinF, 28 Homo_sapiens_CyclinG1, 29 Homo_sapiens_CyclinG2, 30 Homo_sapiens_CyclinH, 31 Homo_sapiens_CyclinI, 32 Homo_sapiens_CyclinI2, 33 Homo_sapiens_CyclinJ, 34 Homo_sapiens_CyclinJL, 35 Homo_sapiens_CyclinK, 36 Homo_sapiens_CyclinL1, 37 Homo_sapiens_CyclinL2, 38 Homo_sapiens_CyclinO, 39 Homo_sapiens_CyclinT1, 40 Homo_sapiens_CyclinT2, 41 Homo_sapiens_CyclinY, 42 Homo_sapiens_CyclinYL, 43 Homo_sapiens_Fam58A, 44 Homo_sapiens_Fam58B, 45 Monosiga_brevicollis_GI_167517989, 46 Monosiga_brevicollis_GI_167522783, 47 Monosiga_brevicollis_GI_167523717, 48 Monosiga_brevicollis_GI_167524110, 49 Monosiga_brevicollis_GI_167526102, 50 Monosiga_brevicollis_GI_167526156, 51 Nematostella_vectensis_GI_156350442, 52 Nematostella_vectensis_GI_156359300, 53 Nematostella_vectensis_GI_156359932, 54 Nematostella_vectensis_GI_156363375, 55 Nematostella_vectensis_GI_156364707, 56 Nematostella_vectensis_GI_156365799, 57 Nematostella_vectensis_GI_156365937, 58 Nematostella_vectensis_GI_156375154, 59 Nematostella_vectensis_GI_156380901, 60 Nematostella_vectensis_GI_156381346, 61 Nematostella_vectensis_GI_156389378, 62 Nematostella_vectensis_GI_156397054, 63 Nematostella_vectensis_GI_156405242, 64 Nematostella_vectensis_GI_156406586, 65 Nematostella_vectensis_GI_156407073, 66 Nematostella_vectensis_GI_156408249, 67 Salpingoeca_rosetta_GI_326426811, 68 Salpingoeca_rosetta_GI_326428978, 69 Salpingoeca_rosetta_GI_326429298, 70 Salpingoeca_rosetta_GI_326435281, 71 Salpingoeca_rosetta_GI_326437558, 72 Salpingoeca_rosetta_GI_326437566, 73 Salpingoeca_rosetta_GI_326437823, 74 Salpingoeca_rosetta_GI_326437989, 75 Thecamonas_adhaerens_GI_195998946, 76 Thecamonas_adhaerens_GI_195999522, 77 Thecamonas_adhaerens_GI_196000815, 78 Thecamonas_adhaerens_GI_196001479, 79 Thecamonas_adhaerens_GI_196002535, 80 Thecamonas_adhaerens_GI_196003236, 81 Thecamonas_adhaerens_GI_196003740, 82 Thecamonas_adhaerens_GI_196005765, 83 Thecamonas_adhaerens_GI_196007260, 84 Thecamonas_adhaerens_GI_196007480, 85 Thecamonas_adhaerens_GI_196011367, 86 Thecamonas_adhaerens_GI_196012973, 87 Thecamonas_adhaerens_GI_196013209, 88 Thecamonas_adhaerens_GI_196013340; TREE Fig._3_BI = [&R] ((14:0.746129,15:0.33809)1:0.035656817,((87:0.287672,(72:0.670257,((9:0.410832,42:0.352822)0.61:0.102372,(41:0.234499,64:0.237737)0.95:0.165512)0.97:0.264369)0.52:0.165892)1:1.88702,((((10:0.448575,(53:0.205434,(21:0.22454,85:0.36506)0.89:0.091032)0.86:0.158512)1:0.784686,(48:2.12808,(60:0.524135,(8:0.51488,(30:0.62266,75:0.978323)0.65:0.176669)0.95:0.299752)0.85:0.400982)0.97:0.606633)0.78:0.377348,((69:0.986848,(3:0.44179,(84:0.351198,(35:0.219854,63:0.294063)0.99:0.123916)0.86:0.083454)1:0.271985)0.85:0.154604,((12:0.368136,(88:0.817013,(61:0.222316,(39:0.10022,40:0.117625)0.97:0.080934)0.91:0.11965)0.97:0.164667)1:0.47292,(((7:0.895392,77:0.615026)0.51:0.184126,(62:0.57329,(43:0.05756,44:0.161253)1:0.610208)0.9:0.267255)1:0.582675,(4:0.298539,((50:0.531624,73:0.339503)1:0.422291,(83:0.18677,(57:0.421645,(36:0.115008,37:0.126967)1:0.149775)1:0.123913)0.86:0.083342)0.99:0.157661)1:0.64348)0.8:0.272954)0.52:0.142572)0.99:0.586296)1:0.783068,((49:1.68225,((1:1.22203,65:0.478248):0.109412,(33:0.276984,34:0.491969)1:0.279374)0.62:0.309725)0.94:0.35488,(((2:1.69598,(31:0.425672,32:0.868361)0.65:0.229896)0.54:0.217956,(66:0.523243,(28:0.462322,29:0.397724)1:0.63342)0.7:0.202641)1:1.07244,((22:0.310373,(51:0.25116,78:0.57807,(23:0.132946,24:0.281669)0.99:0.10386)0.54:0.121299)1:0.847307,(71:1.64701,(80:0.599362,(11:0.808379,54:0.425887,(25:0.254938,26:0.461125)1:0.20732)0.78:0.155501)0.99:0.391184)0.87:0.35823,((38:0.995691,86:1.20404)0.92:0.550342,(((46:0.874434,74:0.736848)1:0.453747,(13:0.676549,76:0.505936,(27:0.434983,56:0.364576)0.98:0.181858)0.81:0.18799)1:0.975622,((45:0.487442,67:0.19044)1:0.26337,(82:0.52373,(58:0.233549,(16:0.263334,17:0.222215)1:0.179692)0.96:0.107997)0.99:0.130325)0.99:0.165273,((70:1.70645,(5:0.319101,(20:0.437563,(59:0.465119,81:0.323587)0.96:0.109076)0.97:0.117152)0.97:0.241065)0.57:0.157269,((52:1.06011,79:0.472307)0.95:0.192389,((6:0.790764,(47:0.206605,68:0.357928)1:0.237865)0.86:0.128736,(55:0.357686,(18:0.224812,19:0.293147)1:0.163109)0.91:0.104451)0.98:0.135317)0.98:0.16382)0.59:0.175425)0.63:0.166667)0.79:0.136603)0.56:0.249386)0.64:0.274861)0.96:0.510679)0.96:0.753028)0.94:1.5332432); END;