#NEXUS [!This data set was downloaded from TreeBASE, a relational database of phylogenetic knowledge. TreeBASE has been supported by the NSF, Harvard University, Yale University, SDSC and UC Davis. Please do not remove this acknowledgment from the Nexus file. Generated on April 19, 2024; 19:14 GMT TreeBASE (cc) 1994-2008 Study reference: Arkhipova I. 2006. Distribution and phylogeny of Penelope-like elements in eukaryotes. Systematic Biology, 55: 875-885. TreeBASE Study URI: http://purl.org/phylo/treebase/phylows/study/TB2:S1732] BEGIN TAXA; TITLE Taxa1; DIMENSIONS NTAX=50; TAXLABELS Cercyon_ex_Schistosoma_japonicum Cercyon_ex_Schistosoma_mansoni Nematis_ex_Caenorhabditis_briggsae Nematis_ex_Caenorhabditis_remanei Nematis_ex_Caenorhabditis_sp4 Nematis_ex_Pristionchus_pacificus Neptune_ex_Acropora_palmata Neptune_ex_Anolis_carolinensis Neptune_ex_Anolis_sagrei Neptune_ex_Fugu_rubripes Neptune_ex_Hydra_magnipapillata Neptune_ex_Nematostella_vectensis Neptune_ex_Oryzias_latipes Neptune_ex_Sphenodon_punctatus Neptune1_ex_Danio_rerio Neptune1_ex_Reniera_sp_JGI2005 Neptune1_ex_Xenopus_tropicalis Neptune2_ex_Danio_rerio Neptune2_ex_Fugu_rubripes Neptune2_ex_Reniera_sp_JGI2005 Neptune2_ex_Xenopus_tropicalis Neptune3_ex_Fugu_rubripes Neptune3_ex_Xenopus_tropicalis Neptune4_ex_Xenopus_tropicalis Osiris_ex_Penaeus_monodon Osiris_ex_Tribolium_castaneum OsirisB_ex_Aedes_aegypti OsirisC_ex_Aedes_aegypti OsirisD_ex_Aedes_aegypti OsirisE_ex_Aedes_aegypti PLE_ex_Phaeodactilum_tricornutum PLE_ex_Selaginella_moellendorffii Penelope_ex_Aedes_aegypti Penelope_ex_Bombyx_mori Penelope_ex_Drosophila_virilis Penelope_ex_Drosphila_willistoni Perere_ex_Euprymna_scolopes Perere_ex_Schmidtea_mediterranea Perere10_ex_Schistosoma_mansoni Poseidon_ex_Anolis_carolinensis Poseidon_ex_Branchiostoma_floridae Poseidon_ex_Ciona_intestinalis Poseidon_ex_Eptatretus_burgeri Poseidon_ex_Fugu_rubripes Poseidon_ex_Hydra_magnipapillata Poseidon_ex_Oikopleura_dioica Poseidon_ex_Oryzias_latipes Poseidon_ex_Petromyzon_marinus Poseidon_ex_Strongylocentrotus_purpuratus Poseidon_ex_Xenopus_tropicalis ; END; BEGIN CHARACTERS; [! TreeBASE Matrix URI: http://purl.org/phylo/treebase/phylows/matrix/TB2:M1726] TITLE 'Penelope-like elements'; LINK TAXA = Taxa1; DIMENSIONS NCHAR=1000; FORMAT DATATYPE=Protein SYMBOLS= "A C D E F G H I K L M N P Q R S T V W Y" MISSING=X GAP= -; MATRIX [ 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 170 180 190 200 210 220 230 240 250 260 270 280 290 300 310 320 330 340 350 360 370 380 390 400 410 420 430 440 450 460 470 480 490 500 510 520 530 540 550 560 570 580 590 600 610 620 630 640 650 660 670 680 690 700 710 720 730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910 920 930 940 950 960 970 980 990 1000] [ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .] Cercyon_ex_Schistosoma_japonicum ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQKDKWIIIINEDKSSTTVVMNRTDYNEKAIRHLS-T-EPYLMVNSKNHTTIKKKKVKSETGRLLKELKPFIGVSLWFTFYS-----KSCTTPCFYGLPKIHEPGI--------------------------------------------PLRSTVDFTNTPIYVLSRYLSRVSKPLQQ-NLHNAVKDTYDFKSEISDLIVEHI-----ETMVSYY------------------------------------------------------------------------RSGNGSPVSLNVANLFIAHIEYHIFKYVIRSR--------VWFRYVHETFVII---EKTFLRT-FSRRINT---LSQYIKFNFESEDEHSELPFLDCLFKRN----LNGTLNLRTYHKPTHSNR-HIDFDSPHLFSAKTSLTLNLFRRVNKLITSKDGKKSEYKNVISILQLNNFPMNIIKNLQNRNDLLLTNNKS---------IKPSGIGTAGLPYRH---DTTEGLQ-----------------RILKQYGIKIFYKT-TNTIRGALVKIK--DKIPFTST--------------------------------------------------------------------------QNCVYRLGCV-----DCDAFYIGESSREIRTRAKEHESYTKRPPNNPVELEKLQIK------SAIPVHAIYY-NHEIDVKNIQISQKGFSNCKEKR-------MAETFHILLNP-----TALNKKEELAIRPT-- Cercyon_ex_Schistosoma_mansoni KKKIIKISKPTIEENTNNSVVNLSK--QPLTNTEEQLLRKGLNYNTSDASKLE---------------------------------------FYAALESSL-K--------------------------------------------------------------TSGISEETQ---QEIRQSIVPLTQRMKGNNQLTSQEQTAL------------KKLRTRKDIVIVPADKGRTTVIMDKEEYIKKAEEILE-DKSTYKPM-DINPVKKLDNRISKTLNKLVKAG--EITKQDQWRMKS-----NGPVLPRFYGRPKIHKPNI--------------------------------------------PLRPIVALPGTPTYNLSREISRILKHLVD-SSNHSIKSATQFLDQIRNIQINDD-----ELMISFDVTALFTSIEPNLAKETLSLLLTNDENLAKYTKLQ-----------SQSLLELIDLCLTTYFQFNNKIYKQTKGTPMGSPISGLIAEAVMQRLETTILPVIKPK---------IWIRYVDDTFVIV---KKEELEN-TYKQINN---VFNDIKFTMEQES-DNKLPFLDVLITRT----DTGKLETQVHRKPTHTDQ-ILNYNSNNPRTHKINCVQTLFKRARTHCNTITARKNEEKHLKTILQKNGYPINFIKKYQSHQPSETKS------------SIKINKR-ITLPYIK---GISETTTR----------------LLKTFGIGVAHKP--TKSLHSILCKPK--DEMAKEDK--------------------------------------------------------------------------TNIIYKINCT-----NCNKHYIGQSGRPLHLRLHEHQLAVKRHDIS----------------SLISIHVDNY-GHTFDWENVQILDRGNSKNTRE--------FLEAWHSGQSAINKH-IEINPIYQPIKKIMQE Nematis_ex_Caenorhabditis_briggsae -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSENPQKI-QKFRSSEIEKFK---NSQKKVFDVEALYTNIDNRAAYQAVVDKLKKNASVIDWYGDSF----------THIKMLLKSCLEFNGFQFDGRIYEQKRGLAMGSRLAPVLAVLYMDIIETPSKVHPII----------LFRSYIDDYIVVAE--SQDTLDN-IFTCLNS---QATHIRLTREAPK-MDWLSFLNCELRFK-----NKVFSSRWYRKPSNKNL-LIRMDSGHPKQQKINSISTLKKRPRKLNDPKELL--SEPSQRGAF-SNGYPPKGYPHKISKIYRNDYTTDK------------SNIPILAIPFVSD--SVTNLVRS----------------SLNQVRLEARVVELKGKSLRDLLVKNRLYDV--------------------------------RCTRR-QCRVCPNIGEGGCER---------------------------KGTVYQIDCD------CGEIYVGETGRPLAERFNEHSRAAEKPGTKAYLA------------TTWAKHSRE--KHGGRPLNISLKILDIERNTVRRKI------LEGIHIKAKN-----PSLNTKEELTDLVAGM Nematis_ex_Caenorhabditis_remanei VHTKKSHRTREQKVALLENITILGD--VNISDAAKMLLSKGPKFALSGKFNQKVLSRLSMGFVSLAATLRTRAAS------------RSQNGITWDTLPPIPFP----------------------------------------------------PAHFFLHPKSDKTDQQVAAA-FNIFMKKINEQKCLHIADNMSKKMWSAL------------KELGQNKDINITVSDKRGEFVITTNAFYRESTILHLT-DTSVYTKI-TKTEYNEEVKKFYGGIESVLKS----WNKKTADRLTD-----CHPSKNTLYILYKTHKFEERGEK----------------------------------ATPSNTKVRPIISGVGGPTDRPSWVVCTIISQFLQ-FVGCHLQNTNEILKSLNDIRGKKIKT--EIFYESFDVESLYTNIDNEAAYEVVITKLKQHYAQIKWYGVSF----------RDIKSLLKTCLNFNAFVFNEQHYVQKRGLAMGSRLAPVLAILYMDKLESPSKSLPTL----------VFKRYIDDFIVVAE---SKEVLDSVFKLLNA---QTPNIRLTRETPS-NGWLPFLNMEITVE-----KGIFATRWYRKKANKNL-LLPIDSHHPTKQKRNIYDVTKSTAMSMSSITHRDY-SMELAESLLRKNGYNSRPKCPRFTFSEKKQVSNSNG--------KLFTDLPILPIPFVSD--WTTNTVRN----------------TLAQVGIKAMIIELKSPNLRDRLMKSRRFDN--------------------------------KCQRR-QCRVCPFIGNGGCGK---------------------------KGVIYRIDCD------CGDFYIGETGRPLAERFNEHSRAAEKPGTPSYK-------------TTIWSKHSFE-KHQGSPLSLKLSILETERNTTRRR------ILEGIYIKTVN-----PTLNTKEELSDMVADL Nematis_ex_Caenorhabditis_sp4 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CQKIKKAPRGSGI--------------LEEQRRTALSISDKGGEFVVSTRDLYRETVEKHLQ-DRSVYREI-RQLEYENAVTLLKHAQEEVYRS----WNRWTVDRLMD-----PHPSINTFYGLYKTHKFVERGDK----------------------------------ANSKNIKIRPIISGSGGPTDRPSWVVCTIITQLLQ-FVPCHLKSTSEFLEELGRINSPNE-----LHYESFDVESLYTNIDNRMAMEAVVRKLRKHSTEIEWFGMSV----------REVTHLLNACLNFNMFQFNNKLYAQKRGLAMGSRLAPVLAVLYMDIIECPSKIHPTR----------LFKRYIDDFIIITE--SQETLDQ-VFKSLNA---QAETIKLTREKPS-EGWLPFLNCQIRQR-----GNGFETKWYKKPSNKNI-LIRIESCHPIRQKRNIVKVTRKTAERTTSEGNRDEAEKLAA-KILLKNGYGTEWEKFRNTKGHRWKQPSRKTDPG-----KPVT--TILPIPFISD--QLSDLVRK----------------TLNDVGIDATLVELKGKSLKDQLVHNRLFDI--------------------------------RCDKT-KCRVCPTLGVGACGK---------------------------KGGIYQLTCE------CGEAYIGETGRPLVMRIDEHVRAANNPQRPSYA-------------TNAFSKHAKA-KHGGLPIRLTLKLLTIKRNTTRRK------ALEALYITTQS-----PSLNGKEELTDLVAKF Nematis_ex_Pristionchus_pacificus YLCPSIIPSCSSPSSSISRVSVASD--VVLSPDAISVLSLGPKFVPSRPFPRDITLNLSISLHQLSFSLRWAHTL-----------LGNSSSSIDPLVHKIPFP----------------------------------------------------SVRSGVPPPVLSIDSKISRL-STHIRDIVSNHRVLPLCNNLSRAQSSAL---------RDLRSQISSGSLRVTKSDKGGDFFVVPQSLERDIVKLHLS-DPSIYVTS-SSAQFKRTCDSIHRQFRAISPNI--SLPKRTVDCLLS-----GVPQVPVMYVLYKTHKCDLASAG----------------------------------NDPSRYPIRPIIVGCGGPTDRISWFLSQLLIPLLK-HVPTHLTNTRDALTALSSLDSNPD-----LCFESFDVSALYTNVSNRDAIRATMSLLSSHYRSLDLRGLSL----------LDIEDLLNSCLDCNIFAFDGLFYAQIRGLAMGNRLAPILAVIYMHYIEAQSIRDGIV----------WLGRYIDDYIVVAV--TQNHL-DSLFTSLNT--IGAPHIKLTRETPT-DNWLPFLNFQLSLT----PDGVFNTKWYRKPANRNI-LLHASSCNPSHSKRSIVISTIRTAINVSSHTYRSQ-SRSLANHIVSSNGHCPPPRTKCVPNTRVSRRVDK--------------PLPVFTIPFISD--EFTRDIRD----------------ALCKVDLEVRIVEKPGPNLLNMLSRNRYLDPP-------------------------------KCPLRERCFFCPTGGEGCCQT---------------------------AGVVYLIECS-----LCSHTYVGETGRPLHLRAYDHYKSSRNPTCNSYKH------------NAFAIHAISD--HNSNPISLKGTIIHRESNTCRRK------IAEAMFIVKLN-----PALNNRIELSKESAPI Neptune_ex_Acropora_palmata ---------------------------------------------SSNVVEFRTRLGDYIEDTTRQDVEKFLRRVQLK------AFFHNKEDKSDNTEKDAFETLT------------------------------------------------VKKSKWTPPEGQFASIDYFIK--KCRHDVHKLKSNCNTKLSNLSKEEWTAL------------INLKNRNDLVIKAADKGGATVVWRTDLYHQEAIRQLS-DPTFYTKV-NKDLTPANQKIVKDTIQELITKQ--ELPVTAQNLIITT------PRTSCIYFKPKIHKTQQPRPSIVSACSCPTELISSYFRQSHDTHSQITTFIYQRQQTTHLKYSRKFSIFSGREQNHFTCFVDRLIQPIAQ-QQESYLKDSKDFINFIENTKLPKN-----TILASKDVTSLYTNIPQEEGITTVCKAYEDFYKNRLPIPI------------NFLRRMLCLILKENSFQFNKRHYLQTHGTAMGXKMGPGYANLFVGLIENKFFSNYHGPKPD------LYKRYIDDCVGATS--SSKEELNLFINSVNS---FHPALKYTWEISE--NSLAFLDIKLSIN-----DNGLSTSVHYKPTDSHN-YLLHSSSHPQHVKNAIPFSQFLRLRRLCSDDTDFNNKCEEMCQFFKKRGYPDSAVTTGKHRAQEIDRETAL---------QTSQNEETDRIPFTLTYHPQNLAIKNVILKNFKILRNDPETKHIFSLPPLISFKRDKNLGNFLVRSAFKFNNQP----------------------------GTFTCKRT-RCKTCPFISNTVKISGPNRSVKVTDH-----------FTCISTNVIYCITCT-----LCKKIYIGETGRRLADRFREHLRDAEQNNTDAS--------------KPVARHFNLP-NHSHHNMTICGLSLHHGNTESRK-------NLEQKFIFQLGTLSP-HGINERLSFH------ Neptune_ex_Anolis_carolinensis RNRPNCFFLRGSKCQTEDLVVNLSR--RVLTPQEREVVNKGLSFVPKPKYNPFRMRIELARLFRTIRLRHHFGTKIN---PITSTFKPRSNFFPTTDHIGLRV-----------------------------------------------------------------FEKTVS-----EELCCTIIKHKRSYSTNFSSKEWHIL------------HNLANDKDLVWKPADKGGAIVLMNRTDYMDEIHRQLS-VREHYLNI-ERDPTHHIQSIIRTVTLEGLAL--GYISEDVYKFLHTPW-----PRIPVLYTLPKIHKNIRP------------------------------------------VPGRPIVSGSGSVLEPLAKFVDHYLQPFVK-QTSSYVRDTKHFINIIESLVIPTD-----AVLMSVDVISLYTNIPLEEARYICESTLNRRANHHPSH--------------LFFVDLLDIILEKNYFKFDEKYYFQIQGVAMGSPVAPAIANLFMDNLENETILNHTKNPVADG--IIKYCRFIDDIFIIVI--TSSNGYYLINTIHSN------------STETSVLHLNFLDVVYRNDRLKVSN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Neptune_ex_Anolis_sagrei RNKPNRFFSRGSKCETENLIVNLSN--RVLTPQEKHVINKGLTFVPKPKYNPFKMRIELARLFRTIRLRQHFGTTKN-----------ITTSTFKPRSNFFPSTDHI--------------------------------------------------------GLRVFEKTVC------EELCHTFTKTKGTHSTNFSNSEWNTL------------RSLANDKNLIWKPADKGGAIVLMNHTDYMNEIHRQLS-IREHYLNIER-----------------------------------------------VFYVPPKIHQGNMP------------------------------------------PPGRPIVSDSSSILEPLEQFLDYYLQPFVL-LMQSYMKDTKHFIKIIEDLTIPPQ-----SILMTLDITSLYTNIPLDRTRTIILELLNIREPQTPAS--------------HILMDLLDIVLQYNFFRFKTQYYLQIFGVAMGSPLAASVGNLLISNLEESHILHDTKTVGFFLPDILYDGRFIDDIF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAEKPYKCTECGKSFTIS--GNLKKHQKMHIK---------------------------GMSTKCL---ECGKCFGTNKSLALHRRMHAGRNRVNSETMGNPSIVSEEILTSAGVYRTPCS------CGQVYIGTTKCIPQTRIKEHERNCRLIQPEK---------------SALTEHLMNQPGHSILFENTEMLKHSNNYHVRL--------HRDATEIHKHV-----DNFNTKEQTMKMNKIW Neptune_ex_Fugu_rubripes FFRIKESRRGGGASTTNKEVINLST-HFQLTQQQLSLLNRGLSFVPTTTASRATRQIFAMDLYRYHRRLKLSAYF-----GPQPPRGGKTFTGISTWEPDISQ----------------------------------------------------------------LPSPLLEL--ISEDGRVLNNLKYRPETPNLPPEEVQAL------------KELRKNYEIIIKPADKGSGIVIMDRPDYVREALRQLQ-DRQYYIQL-KKPIYRETAEIIAAELQVLYESK--IITKEQQKYLLG----PRPPRPRYFYLLPKIHKPRGKWT-----------------------------------IPDRIPPGRPIVSDCGSESYGVAEYLEHYLTPLSI-QHPSYIKNTQHFLSKIGALTVKEP-----CFLFTMDVCSLYTNIEIPRGMGAIRKVLARHPDPNRPD--------------DVLLRLLEISLRRNDFVFQNKFYLQVKGTAMGKRFAPAYANIYMAEWEEEGFKKCKQLPL-------IYLRYLDDIWGVWT--GSREDLDNWVRVMNE---HHESIKVEVTTH--DTEINFLDTTTFKGPNFWETGRLDTKMYFKPTDSHS-LLHKKSFHPKHVFRGIVKSQLLRYSRICTQKQDYEDARKVLFTALRKRGYSRGFLRGINKSWDQAPTREKTQGKH-----GVPVVV--TYSTFGK---QVIQVLRRNFGR------------ILKGTALDKTFRG--IPAYRGNPTLKQLLIRAKLPER-----------------TRRGISGIRKYT-----SIKDPVTKHG-FRVPNHIPQTQ------------------ANCVYIIKCT-----KCRKFYVGETGNGLNTRLNQHRYTIRKNLEQK---------------SHLITHF--Q-DHGISHFTGYPLEHDPNWTTAQRR------RRERYWMDKLHSYYP-LGLNERRPGVSLE--- Neptune_ex_Hydra_magnipapillata KRWVDSEKVRMLTALTDKMITNISD--HVLTNEEKEALGKGLKFIPNSQKVGREVYEASVEKFKRKLRLKMFFKDRKEQKRSVFYKKSSWVPPETENENILEY------------------------------------------------------------------FGKID-----RDLEEMWNREIPRKRNNLKPEVWRAL------------KNLQNNRDIIIKKTDKGGGLCIMNKTTYEEKVNELLM-DRTVYREL-QTDQTNNIVRGITDMSNYMLKLH--KINEQTAEFLLPHK----PCRPPLFYGLPKIHKPNI--------------------------------------------PLRPIVSACSGPTDNLSEYLTRFIQPLVE-SLPAYIKDSIHFLNMLQNIRLQSSE----FIFVTADVTSLYTNIPHRDGIDAVVHYLRLIPLQDRPPDCPSP---------GIIGNLIEEILSNSTFSFGDKHYHQLTGTSMGTRVAPCYANLFMGRLDEQITNQFPNHIT-------FYRRFIDDIFFIFQ--GPIEVLDQICNFMNT---IHPTIKFTFNHSA--TSINFLDILLYKN----EQGNIHTTIYRKPTDTMG-LLHYDSHHPTHTIPGTIYSQALRYCTIITELNNLQKELKYLTMTLVLRDYPLHIINNNIKKALHKTQHELINNRRA----QENTERLTIVTPYTPIGQQINSIILS----NWNMI--DPNLQLQDIFPHKPLSVHTNLKSIKDLLIHTKHQQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Neptune_ex_Nematostella_vectensis RRRRRRRKNNSVVTLDSTSVINISS--TSLSPDETSVLARGLTFCPTPRKIDWSQVNADIYDFNRRMRLAEYFFNEDKPNDNDTLSFDSSFNPFRNKSTWTPS--------------------------------------------------------------SGRDNSLDTF--LNSVKLQIQNSTLNKTRSNITPGERNAL------------TQLNQRQDIIIKPADKGSGTVVMDKDWYINECNRQLN-DTKFYTQL-DADITNDIQKRVTTYINRMHTDG--IINQDTKSYLTPK-----DSKPGRFYILPKIHKHGN--------------------------------------------PGRPIISSNSHPTERISEFVDYYLQPLVS-KLPSYVKDTNHFLNILLTLSNLPTD----SLLVTLDVSSLYTNIPHNDGINACHHFLRTCNTNPIPAG--------------TICDLIRMILQMNNFSFNDKHYLQKHGTAMGTRMAPSFACLFLGLFETNALRDAPYKPH-------TWLRYIDDIFVVWT--EGLDKLNAFVDYLNN---LHPTIKFTSSHSY--NNVPFLDVNVSLV-----NSKIETDLYSKPTDKHQ-HLLFSSCHPHHTKKAIPYSLALRIRRICSTEESFNNRCNELTNYLLKRGYKPAFLKRQILRVANISRIDALRPNNN-------NHKNSRRIPFVTTYNPTLPNINNIIRRNYNLLLSSKRCHKVFTEPPLVAFRR--SPNLRDILVKAKLPSDRSPT---------------------NQPPGAFRCE--KNCLTCPYIRTDGLTSYTFFSTGETRPITSH-------ITCNTKNVIYMIQCN-----RCNLQYIGETKRKLKERFNDHRRTVDSQSRSIP--------------THAAEHFLKP-NHSASDIELIPIEKIRNNRDSIRK------AREATLIARAGTLEP-GGLNRREETV------ Neptune_ex_Oryzias_latipes --------------------------------------------------------------------------------------------------------------------------------------------------------QPFTLKSDWTPPSATLPPQINRL-IDQDISYFENDFKIIHNTPNLSGEETKTL------------KELAQNNDIVIKPADKGSLTVIMDKKDYLYEGYRQLN-DVTYYHKL-NKPIYLDTIPLVDTIINNLLKKK--FINKKQKTYLQGNS----QPRPRRFYMLPKIHKDPQKWT-----------------------------------VPSKIPPGRPIVSDCESETYYTAEYLDFFLNPLSN-KHDSYLKDTYHFIEKIKQLVIPAD-----SFLFTMDIDSLYTNIDHKEGIDSIKRIFQKYPDKKRPDK--------------ELLQLLEINLNRNDFEFNGEFFVQIKGTAMGKKFAPAYANIFMAEWESSALQKCALKPL-------CYYRYLDDIWGVWT--HSEQEFGTFLGTLNS---HNPSIKLKSTCHA--SSVDFLDTTTFKGSDFHTTHKLDIKVYFKPTDTHA-LLHKTSFHPKHTFAGLVKSQLLRFHRICTQQADFKKATKILFSALYTRGYSRTFLRKCFKSFQQIKTIDTSPLLPIV---TTYSAATCRMVRVLRR--NFRDLVQDQGLLKEHR--------FLPAYRRNKNLK---DILIRAKLPPPTPPKS---------------------------------------RALTSFFKHLDWICSHHNKNVFPSLCR---------GSPHSQNCIYVITCS-----TCGIQYVGETGNTLLVRFTQHRHNITKHKNTD---------------TYLVQHFI---SHGWDSVNATIVQMNPRWSTPERR------RQERNWIYKLDTLHP-RGLNEKKTPIF----- Neptune_ex_Sphenodon_punctatus --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VSTNTLNQARKTTSSQCKAQSTGV-MCYCYIKP-YCYKNNEIKEGIKTLLQEGLVKG--YITEQEFNLLLN-----SSPRTPVFYILSKIHKKKLP------------------------------------------PPGRPIVSASNSVLEPLAKFVDFFLRPIIP-QLQSYSQDSTHFLNIINNTDYGRLKFG-SVFLVTLDVVSPYSNIPPDRALTIVRSSLKLHHVQGPPP----------------GYLCHLLGLFMTKKXVSGFFYLQNLGMAMGSPWLQKLQTCLWVLMSTVLYLTLIQTP--------FIDMYTYGGGLIWT--GSEAELKGAHEFLNG---CHRNISFYLHYDK--FSINILDIRVTME-----KEGFTTFTYVKPTDKNT-YLHYHSFHPLHLRKNIPNGRFLRARRNCSSDVGYRLESDRLYQDCS-RGYPRRYLDSARTRVSRFTHKELLDKQQN----NSATVRHVCSLTFG----HLSTWIRS----------------FILKYWRLISHSPSCDLP--PLFVYKRTRNWDDLKPLALQKDTK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Neptune1_ex_Danio_rerio STKIPDPGQIHTEPNKGDEVINISN--ISLSTSCTSVLSKGLTYSPVNTANEFQT-KVDLFKFHRNLQLKVWYHTSTA--EARTYEEKKTIFKPKSTFIPCVS--------------------------------------------------------------NPTLNSFYK---KVSYEMDNIFASKKKKHFNLSKDEINAL------------DWLSTNDNLIIKRADKGGAVVVWGRDDYIKEALRQLQ-NCEYYQPL-KFDPAEKIKTELMEILTFAKTEE--WITQNEFEFLWS-----KEPRIPTFYMLPKIHKNLEN------------------------------------------PPGRPIISGNESITEPASKFVDYFIKPIVK-DLPSYIQDTTQVLNTIKNMQCDKT-----CILATMDVESLYTNIDHREGLEALLYYLEKRPSPKKPPT-------------CFIVQLAEWTLKNNVFLFQDQLYKQIKGTAMGACFAPNYANLFLGLWEERFVYSESNPYLSSIV---WWGRYIDDVILIWS--GLEADLRQFHAFLNN---TNANLRFSLDFS--FTQIHFLDLNIFKD----TTGKLHTTIFRKETDRNT-ILRADSFHPPWLIENIPFGQFQRLKRICDKEEDFEIKSQDMVHRFKQRGYKNRVIYKSYNKAKDSNRDELLIKRP-----RLNQSE--SSVYFVTQYSTEANTIKRIIKNNWNILMSDPHLREILPVSPSVVFRK--APTIQDKLVRSHLSSKK---TNTW----------------LNQTTGNYRCG---NCNHCENMLKTNMFRDPSSGREFKINSFINCNT---------TFVVYRLECP------CGCFYVGMTKRKLKLRLAEHKYAIRTCNPQY---------------PMALHYKNQG-HGNPSSLKIVGIEHIYNSTRGGDRIKRLK-QRETFWIYTLKATRF-PGLNGELDFSSFL--- Neptune1_ex_Reniera_sp_JGI2005 ---------TVDLIYSHPKTANLIIF-DHPLTDFNEILAAHIFFENHPPRSARTM----------------------------FIAKFTWTPPQAAIHPEILK-------------------------------------------------------------------SFAS------MNSQTVNLSITHEKPNLTRVEREAL------------NVLKKDDSIVIKKSDKGSCCVILKREDYVTEAENQLN-NPKHYAIL-PKPIFKETANMINNILADLVKT--SYLKQKQYDYLSAKP----DCRERHLYTLPKIHKNPTKKWF----------------------------------ISNKIPKGRPIISDCGSESYAVSEYIDHFLLPLAC-QHRAYLKDTTDFVNKIKNLRVPSN-----AILISIDVSSMYTNIDNTTGLTAVRKAFNRNPDPNRPDD--------------AILQLLEICLSRNDFTFNGKTYLQTSGTAMGKRFAPSYANLFMAEWEREVLPLCPFDPL-------FYGRFLDDIFMVWT--YSIEQFWEFFEILNN---HHPSIKLTANVSD--KSIDFLDTTVFKGDSIAETNKLDIKVYFKETDTHQ-LLHKSSFHPKHTFSGIIKSQVLRFHRICTRSSDFNQACTIVFSKLKERGYSKRFLRNIKNSTLAQIAA--------------KNRLYAEVPPGLRSAPCLSSRCKTCP--------------FISETHYFVSNSTNKRYPIQEHLTCEH------------------------------------------------------------------------------------SNVIYLISCK-----KCPKQYVGETKNNLRTRFNAHRSDIKLKKD-----------------KPVSNHFNLD-DHSIDDLTLIKKLIATANKTFPNSKILFTCIPISNKISKKAQQKL-STLNNMMMESSINSAT Neptune1_ex_Xenopus_tropicalis LVLKKYFLNDLNCVQLE-QPVNAATP-GSLIENG--SDSQGLSFPSMSDNLNCQLLFQDERCLQNLYALQ-------------NESDTSIHRFGVDPEEIRDG-------------------------------------------------LRMTSDFYPLHCRGSVVDRFQEL-IEKELLSLKMETRSQFTGFNLTSQEKAAL------------KQLQDDKSIVIKNADKGGMVVVLDSETYKNEAMRQLN-DISTYQPL-STDPTIEFTKNLVELVNDAYKSG--LFNERIRDYLIP-----TSPRVPLFHHLPKVHKSERP------------------------------------------PLGRPIVSGIASLNEKLSEYIDLYLQPLVK-RLTSYVMDTKHVLQLLNHLEWSDT-----FSWGTIDVASLYSCIPHEKGMLAISYHLDMYSTYDEGTK-------------HFILDSISYLLSHNFFLFDQVFYLQRCGTSMGAKFAPAYANLYMGWWEETHIYGGDSLYLHN---IVFYKRYVDDLLLVWQ--GSHSEFSLFVTELNT---NTLNLRFTSEFNT--HTISFLDLKLVAR-----GTVVETTTFRKACAGNS-LLRADSCHPAHMFKGIPVGQFQRLRRNCSTESAFLEQAVILRDRFLDRGYSMRSLSSAFTKALRMERSDLLTNKKGQH--HGRVGRGNVSPTFVTSFSNQFYKIRRIVSNLIPVLYNDPD--LALVLQGGYNIVAKKAPTLGNILSPTLWQSRPLR-ATWL------------------TVKGTYRCG-ARRCVTCSHIRQSTTFSSSVSGTVFNMHFY---------ANCNTRYVVYLLTCSR-----CRIQYVGCTTRSLKSRMREHIRHIAARNSN----------------SPVARHFLQC-CQSDVSFLHIQVIDKVLPDARRSDLYVRLLRSEVKWIFTLDTRHP-NGLNSIFDISCYV--- Neptune2_ex_Danio_rerio KRSPIRDTSQVASSLNCQNVVNLSS--KPLSSDCLQALEKGLSFVPTTYCNEFNVFLDFQKFFRTLRLKEFFSSNDSRLNLCPPTQHNTNSPPVNNLAIDPGA-----------------------------------------------FHKKSTFMPPKNKNFSVETYCRLV---GRDVGQVLNKKREYTVFNNMPVAQRNAL------------HDIKNDKSVVIKPADKGGSIVVMDTQYYDQEIYRQLQ-NQSFYTKL-RGDPTNNFKKEIYDSLQTFLLRG--DVTNKEFEFLKVD-----YPITPVIYILPKIHKNLAK------------------------------------------PPGRPIIAGMGSLIEKISVFVDSFLKPHVQ-SLPSFVQDSQDMIKILQSVSLPQIP----TLLVTLDVESLYTNIPHDGGIQAIDFFLREFLSDKKP-T------------IECLKELTKLVLTKNYFMYKDDYFLQIKGTAMGSTMAPNYANLYMGFFEHEYVFNPTVNSYLSN--ILLWRRYIDDIFMIWC--GSENDLLVFQQFLNH---TSEHLKFTIEFNP--SQVSFLDLLIIKDG-----SKLVTDLYRKPTDKNT-FLHGLSFHPTKLKKSLPISQFKRIRRICSDTETFEKQRKELCQRFYDRGYSTKWIKEAAARFENMDQKEALVRK--------TLKPTNTRISCIIQYSALSNEFANIVRRHWHILNSDPVMRHCCKDPPRIVFKR--APNVRQMIVRADQGSDR-SDNPFS------------------VPEGNYRCG---QCAQCNFTTKCQFFSHPHSGKQLKIKGV---------ISCNTKNVIYMIKCP------CGLAYIGKTRRCLKTRIAEHRSNIRLNDQR----------------NPIAVHFNAL-KHNLATLRYIGIEQVKVPRRGG-DVDRLLLQREAFYIYTLNTLSP-RGLNLDFDLKSFL--- Neptune2_ex_Fugu_rubripes SVGKLISPTNLQFQEGDKNVINLSKK-CKLSPAQSSLLSKGLTFVPTKGSNKDLINSTRFALQQYHRKLMIAAYFESKGDTDPPPFTPKSDWTPPWTNVPVNI--------------------------------------------------------------------KKII--QRDLEHFDSKFKIKSIKPNLTKAEVEAL------------RSLQNNPLIVIKPADKGSAVVIMDRDQYVLEGHRQLS-DKNYYIQL-DKPIYVETIPMVKQIAQTLYDKK--FINSKQKTYLIGS----EEPRPRRFYMLPKIHKEPEKWS-----------------------------------KPHETPPGRPIVSDCNSETYYTAEYLDFYLNPLSI-KHPSYLKDTYDFVEKIKTLSIPPN-----SFLFTMDVDSLYTNIDIAEGIQAVKNIFVKYPDSKRPE--------------KELLQLLRINLTRNDFEFDNKFFLQIKGTAMGKKFAPAYANIFMAEWEEWALQRCPIKPL-------YYYRYLDDIWGIWD--HPREKFEVFLNILNN---HNPSIKLKALIDS--DSVDFLDTTTYKGPNFPLTHQLDIRIFFXKTDSHA-LLYKTSYHPKHTFAGIVKSQLLRFYRVCSREEDFKVSVKTLFSALVTRGYSRSFLRKCFKTFKKVRPTWCSSLLPLI---TNYSESAIKLVNTVKK--NFYQGIDNSEILQNHR--------LIAAYKKNRNLK---DYLVKAKLKPLSTPKA---------------------------------------TGVGEFFQHCLWVQNKCNKNVFKTQLG---------TGPLTKNCVYLIFCN-----SCGMQYVGETGNTFRTRFYQYKYNICKQHNIH---------------IPIIQHFL---LHGWPALKATILEANPHWTTPQRR------RTERKWIYLLNTLRP-DGLNEK---------- Neptune2_ex_Reniera_sp_JGI2005 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSNPAKFMDHILQPLAQ-AYNDYLKNSTQLISYLETSTIPND-----IILVTLDVKSLYTSIPQSECLESVRNEMFNHQDLIIFDP-------------DLITHLLSINLNNNYFEFSKKVFLQVIGTAMGAAFSPTVANIYMSVLIKRFLSSTTEKPF-------FFKRYIDDIIMLW---PKHQDLNNFFNKLNK---FHPNIKFTMSQSE--TTINFLDITIYKGEDFSETNKLSIKTYQKEINRYQ-YLHFNSNHPIHIFKGLIIGETIRYVRTNSTIIEYKKQIKRFTERLISRGYKINFINTAIRSVNYKNRAKYLQNNNN----NTTTKQRLQQPILKCTPPPNFICIKRIILEQFHEY-------NLSRYSKEPLFVTLKSNTLKDILVHSKHRPSTKDLQKITEKTSPIPQHNQPKRIVTLRTAGPNKCN-KKRCSTCNHFNSSAIFKSTANKRQFKIEHP---------FTCTSSNVIYLITCL-----XCQXQYVGKTSKTLRERICHHRSSINNNEP-----------------RYISKHFNLP-GHQLSHLKVQVIDRSKMERPRNT--------------------------------------- Neptune2_ex_Xenopus_tropicalis AEGPQTAATTQSTDFQKTLVINISS--HTFTSEEMCLLSKGLSFSPVRGCDTFQLDIDLERFFRNLRLKSFFSQPTFKELEKGACNESNLQLTLKKVGLRNKS-----------------------------------------------------NFIPPTSDPIVETYVKLVKSDIRELKSRLKLKPLLNTRHNLTKNEKRHL------------SDILSYKQVIVKPADKGGALVILDKGYYINEIKTQLA-DENVYCML-SNDPLVTIQNKIRVTVGSAYRDG--IIDGETQKFLIKI-----DPITPVFYTIPKIHKNLNY------------------------------------------PPGRPIVANTDSVFSPLSIYLDKVLQPIVH-STKSFLKDTNQLLEILSSCKVTDQ-----TLLASLDVTSLYTSIAHVAGLTAVNNWLQEVTDYTDGEK-------------SFLLDLLQIVLYDSYFMFGDNFYKQLQGTAMGSNVAPTYANLYMADFEKSSVYTNALFQQFCP----LYYRYIDDVILFWE--GPPGTLVEFHQYLNS---VIPTLKFTLIYDT--HTVNFLDVIIRKT-----GSHIETDLYQKHTDRNN-LLHNTSFHSRSLLESLPVTQFKRVKRIVSNRTQCEKRLEEMSERFQARGYPKKKLQEGLEKIREETTEQLRTPS------QRKIKEKEKRLAFVSQFSVASEQVGRILRRHWQVLQMGIPTVTEFSTPPLMAYKR--NKNLKDLLVKADIGSEKKYSQRFF----------------GTPKMGTFPCL---SCAQCNNITKGEFFTHPHTGKNISIKNY---------FTCNSTYVVYLIKCP------CGLAYVGETTQKVKDRIKQHKSNIRCNLQHL----------------PIPAHFHEM-KHSISQLRYQVIDAVGPLRRGGNRQWMLK-KLEMRWINILGTLSP-GGLNREYTPMLFI--- Neptune3_ex_Fugu_rubripes PLKTKPVNRRGLGWDSSSNILNLSTL-FTPSIHQRKLLERGLSFIPHPTKFDREE--LQRDLYNFHRKIKLIDYF-----HLHPKNNPIKFTHPSHWEPESNT--------------------------------------------------------------IHHLTKKLI---HTNTQALKHTTLVTDIKDNISNLERTAL------------TQLSHNPNIIIKPADKGSKVVIMDRQQYLTEANRQLA-NRNHYTPL-PDTIQPQIQHKLRTIIQTLYNKR--YITAKQKQYLFG----PDNPRPRYFYLLPKIHKPPDTWT-----------------------------------IPFEVPPGRPIVSDCNSATYHLSQHIDHFLGPLST-LHPSYIKDTYHFISTIQPMAVPTH-----SILFTLDIDSLYTNIDTTLGLQALHTILNQHPDPTRPD--------------KELLQLIELCLNNNDFLFNQQYYLQTHGTAMGQRFAPSYANLYMSEWEREAFTKCPLRPI-------LYLRYLDDVFGIW---TYTIPQ--FMEFINTLNHHHPSIKLKHTID--TQEINFLDTTVFFNITQATHKTLQTKVYFKPTDTHA-LLHKSSYHPKHTFKALVKSQIIRFHRICSNITDFHNATSTLFQRLRTRGYSKRLLHSIKYDTLASLAP------------------------------------------------------IILDTSLNNYFLP---ITQSLTLKSFPN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Neptune3_ex_Xenopus_tropicalis TPSLTLHSASGIQSSQQTQVVNLSS--FKLNNNHIQLLQRGLNFVPNKDINKFEWIKDIN-LFARKLALFKFFKNKEDKEMRKLGLTRDDLPTLRVLEALQNDNDVDLRG------------------------------------------VVSPYKKQSDFTPNIASYSHIDA-FVNLVTSEIENLKITRGIGNLSLGLTKAL------------EELKNCEHIVIKLADKGGNVVLMEKSEYKAMVSDLLM-DRNSYEVL-SSDPTTTYLASLKLLLEKGKYAG--VISKKDFLFMCH-----EHPLIATFYCLPKVHKQTAK------------------------------------------LKGRPIVSGNGSLTENVSKYIDLYLVPCVL-ELPSYLKDTKDIIQKLQEVKVDSS-----CQLISIDVEALYTSIPHNLGLVGSKYFLTRKYDREKTN---------------FLIDLLHFVLTHNYFLFDGRYYHQIRGTAMGSPCAPSYANLYLGWWEEICALNSAENPFLHK--ILLWKRYMDDILIVWQ--GNKNEFDSMLSQFNK---NDFGLFFTSEFGS--KYLPFLDLSLALTS----QGSISTTIYRKPTSTNS-LLHFSSFHPIPLKRGIPVGQYLRLRRNCSDIDDFKIKAIDLRNRFIQRGYPKRWLKRAYKRALESDRQTLVFSNK-----APDMETKQSDIRCVGTYNNQWQSIKSIMQRHWSVLKGDRD--LGPILPHLPPLVARRSTSLGDVLVHSHYSERRES-PSHF----------------LTPTVGSYRCH---RCEACQYMVPMKSFQRPGSQFKYEIRQF---------INCRTAGVIYVGLCS------CPMLYVGKTFRELRKRILEHIGTINNKKE-----------------TPLARHIRDF-HRSDVTAISFFGIERVKLGPRKGDINNLLLKKECEWIYRLKSR-APLGLNEGFTFSPFIRKR Neptune4_ex_Xenopus_tropicalis TAKYLDVEGDARSLRPSSNVINLSS--KSLSLDETNLLSKGLNFIPDEKLDIFPINLDLNKFIRLLTVKRHFANQDNMNVSGVHNNVDMADSLFQESPDVGQSSIDVSEGTGVQMALDDFRDFCALSDLQDLEAEGSISSGEYPHKLVTVSGMKKNSEFYPIHAKSQQLLMFHKLVQNDIEALGSKLGKNKSKYGNLTPGEYKAL------------HALSRDDTIIIKKANKGGSVVVLDTPAYVAEVMRQLT-DVETYTLL-KRDPTEGFKSVLVDLLSEGFSNG--VLTTREVEMLKCE-----YPVIPVFHVLPKVHKSLDN------------------------------------------VKGRPIVASIGSLSENLSCYIDRLLRPLVES-LPSYIRDTTMCINQIQDLKWKSS-----YRWFTMDVVSLYSSIDHSLGLQAIGYWLDKERIFPKAQS-------------DFILQAVDFLLRSNYFLFDGKFYLQRCGAAMGASFAPTYANLFMGWFERLYIFGDQNPFRSR---IFSFFRYIDDCIGVWD--GDDDTFSHFVTYCNE---RVSGISFTYETNK--DCISFLVNFSSQN------GLIHCDLFRKPITRNT-LLHSKSAHPASCLGGIPVGQFLRLRRICSTWDAFQRQAMALWDRFLERGYTPGVIKAAYERAVSSDRSTLLRPKRPDT--QNVNGKEKSKTRFSMVYSKNAHLIRKSICKYWGILLQDPI--LAKILDKEPSFVYRKGRDMASWLSPSLYTSKKRT-IPWL------------------NYIGNYRCG-RKRCKACPFLNVSKKFNSTHTGAEFQIKQY---------LNCLSKEVVYLITCS------CGSQYVGKTVRNVSVRILEHVSAIESGDLR----------------SAVSKHTIE--KHAGKVSFTFQIIDKVSLQARKGDLEKRLLKREAFWIYNLHSLECQGGMNREWELSCFY--- Osiris_ex_Penaeus_monodon ---------------------------LFFPFFFYPLFFLSPRPHPFTSID-----------------------------------------IIPSFARFISS--------------------------------------------------------------HRNSLPDVS---LLRGAFIPALESLLHPNPSIPRRYREAL------------QSL-RREDVTILPSDKGNSVVVLDRASYLQKAQDLLD-DASTYAPL-TSDPRERIAATFHRRLKEIAACF-PEANLYQRFRVI-------NPRLPHFYGLPKTHKPAV--------------------------------------------PLRPIISSRGSVTHPLAAWLAKCLTPLLGTFSPAHLRHSQDFISPFAELHRX-----------------------------------XDPRLPLPT---------------NVFLQLIRLCVESNFFSFEGRFYSQTFGVAMGSPLYPVLANLFMEFFESELLPSISLRPS-------VWLRYVDDVALWPH--DPALFPD-FLMRLNS---LSPSIRFKVEWEV-DNKLPFLDTLVHRS-----AEHFSFFICRKPMHSGM-YITLLSYHPVHVKEKCXYFRLFPSHPPASVXSLSTXNGK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Osiris_ex_Tribolium_castaneum SLQRVNKTKNFSKHIFHPRVKNFTT--TVFSNEESTLLNKGLKFSPQINLNINRL-----------------------------------EKVAVDCESIIES-----------------------------------------------------------YNIDTKSDLISS--LNNSFNVEKKQISLSDKPPPKDFKILKSL------------KDKITSNNLVFSKADKGNTVVILDKEAYTTKVLEFLE-SGSFKLL--KGDPTTKFTSILKSVLSSTSHTL-EFFNYNKYSLIPMN------PATPRLYGLPKIHKPNC--------------------------------------------PIRPVVSFTNSPCHKLAPFLNNVIRKSINFNNTFSIKNSKDLCDKIKDLVIPSN-----SFLVSFDVSNLFPSIPPSECVSILRNFLLDSKLNITYSS--------------DLLTLTELVTRQNFFQFNNQFFEQTSGLAMGSSLSPLLAELFMNNLEQKILSHKLADQVF------FWHRYVDDVLVLFE--GSETDLSNLLNFINI---IHPSIKFTLEIEQ-NNKLPFLDLLIIRH-----NNHLEFEIFRKPTTTDT-LIPFDSHSPYQYKFAAFNSFFHRLFNLPLTPRAFKKEKDTIFQIGVNNGFPPYLIQKIFNKFEIKFSCTFHLINS-----NREEVRFCHSLPYIG---PFSSKLTS----------------LFRYHDIKVIFSR--GNDLSSSLVKNKDKINIGNHS----------------------------------------------------------------------------G-VYKLTCE-----DCNAFYIGQTGRKIITRVLEHKGYMVKEIREKTNP---PFKT----KSEFSDHLLNN-QHFCNFNNFEVLHICNKSRKLN--------NLEILEIYKHLSLHNSTCVNEQTNFNKPLLNN OsirisB_ex_Aedes_aegypti ADAQATRNARRLPQIIDNFVVNLSS--AQLIKWEHDLLNKGLNSALPPQCAPVAE-------------------------------------MVNNIESAIQY--------------------------------------------------------------NSFPTKSAL---RHDIQRCILDAAGKQNNGTQNDSNTERV------------VRQLKTHDVIYSRADKGNAVVMMDKEDYDARVLDMIN-S-GPYDECKFKNGKPKDPLNALIEEANSTRQK--IARLMGEDKLERRLN-VPNSKVASLYCLPKIHKNPI--------------------------------------------AMRPICSNICTPTEKMAAWLVNEMKGYPV-THGKSVKNSVELVEKLEKVEIRRG-----EILVSFDVAALFPNVPVPDALCSLRRHLERHRAPPNHI--------------NAYLTVAEVCMNQNYFMFRGKFYKQTFGLSMGSKLSPLLADVFMSDFETDLQKEKLFPR--------IWRRYVDDIFAVV---KERYLSQ-ILEMLNS---RHTTIKFTVEKEM-DGKLPFLDLMITKK----EDNTLRFGIYRKPTSTDR-YITADSNHYGAQKQAAFHSMAHRLFNIPMEKEEFVEERMKIHEAAAVNGYDEEFVNKILRKHERKKHRQIATTLQ-----PHKEEPLRISLPFYP---KLTNPIQG----------------ILKQYGMQAAYKS--GHTLKEYLCALK--DKTPAED---------------------------------------------------------------------------LSGIYEIPCK-----DCPSVYIGQTRRKFKIRLREHRNAVDNERVHE---------------SSVAVHSVEL-KHNIDWDKAKLKKSVRKVSHLN--------AWESMFISNAEQ----PLMNDDDAPISSPLFH OsirisC_ex_Aedes_aegypti KTTEVNCVPAPIIEPIEDFVVNRST--QQFTVEQLTHLNKGLGYAVTTKPDVEK--------------------------------------IIVDMETAIIQ--------------------------------------------------------------NVPIKDQNT---TRNIVAKAITTGQR---SKADKDETRIV------------KEL-KDKPVFYIKADKGNAVVIMDKTDYDEQMAKKIN-E-GPYRHL-RVDPLPGLIKLTDKTLKDCKA-----IIGEAR--LKE-----SNPILPRIKGLPKIHKPGK--------------------------------------------EMREIISADGSPTHKLAKWLVKEFQSMPNPFPTRSVKNTQEFSQKLLESGHIED----DEMMVSFDVAALFPSVPVKDSLNLLEDWLLPQRTDAAWKGKV-----------RTYMRLARLCMDENYFQFRGNFYKQTKGAPMGNPLSPFLCELFMANFEENLKKQGVLPD--------KWWRYVDDIFSVI---KRNDLAK-ILDTINS---VHKDIKFTHEEEK-DGKLSFLDLLVTRE----ESSTYNFEIYRKPTNTQR-VIPYTSNHSFQHKMAAFHHMIHRMQTLPLSEHGKTKELEYIYETARINGYKERTIKAIIDKKERQRIRNALTTLT-----PITEPMKRVSIPYDV---HISKQLRP----------------KLRNFGIDLVFSSR-DNQLRTSLGSTK--DPVNTLN---------------------------------------------------------------------------KAGVYKISCS-----HCSKVYVGQTKRSLEVRFKEHLAEMGKAQKTIDKGMTYDFK------SKVAEHIFSE-GHTITTADIKILRNVSSPWKLD--------VAESLEICKQVPT---TLLNRDNGNGNTWLFN OsirisD_ex_Aedes_aegypti KQHNKVVTALPKVHSIEGFVVNRST--QQFSEEQLTLLNKGLAYAVATKPDIEQT--------------------------------------IIDVETAITH--------------------------------------------------------------TIPIEFQES---ARNDTEESLKGNKFQLRGQNSDEDK-VL------------SEL-RDKSVYYVKADKGNAVVILDKDDYDNQMNEKIT-T-GPYRHF-RVDPLPTMVRHVEKTLKECKP-----LLGDNTSRLKV-----SNPVLPRIKGLPKIHKPGN--------------------------------------------EMREIISAEGSPTHKLAKWLVKEFQSMPKPFESRSVNNTQEFASQLQASGYIQD----DEIMVSFDVKALFPSVPVKEAINLLEEWLLNQHNESNWKNKV-----------RYYIKLTRLCMEENYFSFRGNFYKQTKGAPMGNPLSPFLSELFMANFESILKKKDLLPQ--------RWWRYVDDVFSII---KKDYLPK-ILEAINS---IHKDIKFTHEEEK-DNKLPFLDLLIIRE----SSHFEFE-IYRKPTNTMR-VIPSTSNHTYQHKMAAFHHMIHRMQTLPLSETGKSKELDYIFETARLNGYRNSTIQAVVDKRARDKYRKSMTTLT-----AEKEDLKRVAVNFDT---KITQPLAK----------------KFRKYGVDLVFSSR-SSQLKSRLGSTK--DKINKLN---------------------------------------------------------------------------RAGVYKISCP-----HCNKIYIGQTKRTLEIRFKEHIAEVKKADKELEKGLAYDFK------SKVAEHVFQD-GHQMTSDNIDIVRSVSSSWKLD--------VAESLEIYKQKPS---LLLNRDQGNGQSRLFK OsirisE_ex_Aedes_aegypti NPKFSRPSQRPNIHNIDGIVVNRSS--EQFTDEQLTLLNKGLTYAIPKKPDTTQT--------------------------------------VIDIETAINN--------------------------------------------------------------NNLQTSQIQ---EIRTHTANIIRNTNT---TPQNKEHNII------------KQL-NTKPVFYLRADKGNSTVIFDKSKYEEIMQNKIK-H-GPYRIQ-RTDPLPGMIRRVDKALKEAKP-----VLGNVVNSLKE-----SNPSLPRIKGLPKVHKPGN--------------------------------------------EMREIVSAIGSPTHKIAKYLVQKFQNFPKQFHSKTVKNSKHFTEVIENLKIADD-----EVLVSFDVKSLFPSIPVKEAISLLEDWLLSQYEGTDWIKQV-----------RTYIKLTKLCMEENYFSFRDETYKQLNGAPMGNPLSPFLSEIFMANLEKRLEDKNQLPE--------IWWRYVDDVFSIV---KKHILPQ-TLETINK---AHKNIEFTYEVEQ-DNKLPFLDLLIVKE----HSSLTFE-IYRKPTNTQR-IIPNTSNHSHQHKMSSFNHMIHRMLTIPLSETGRRKELNYIFETGQLNGYTRQTIQQLIDKRTREQYKRSLTTLT-----QEQPTLKHIAVNYN----DETKKLRP----------------ILRKFGFELVFTSR-NNQLQTLLGSTK--DPIDSLY---------------------------------------------------------------------------KSGVYQITCD-----HCNKIYIGQTKRTLNTRFKEHVAEVTKAHKDTEKGHVHHFK------SKVAEHIYNE-QHFLNTKNIKLLRHISNPWKLD--------VAESIEIFKQNHN---KLLNKDQGNGYSWLFR PLE_ex_Phaeodactilum_tricornutum ILLRDMPAWLYFSRPLNAAFHNLCSSATTVPSNTRSLLGLGLSFCVRRSRTGGPR-TVDFRRFRRDCFTKMLF----------AGSDPLPPTKLFIRSTWEPPP------------------------------------------------------------DEIPPEFRVRV--ATFSRDVRRLFRRQSCSSNLLPSQSAAL------------RTLRTNYSLIVCKTDKNLGPAIMDRSTYICRAFQDHLADASTYRRLSEITATNRISAVRRIILGFISTTF-PTRNDPTRKFLLRSLE-QVSDPFGYLYILAKIHKTPW--------------------------------------------KTRPIVSVSGSLCHGLGRWVDSQLQKLLPSLPYVYNSSTHVCQRLRVHSDLPLS-----ARCFSLDAVSMYTNIDTRHALSEIRAYFDSSGICERHGVQSM-----------ALLKGLEIIMLHNVFRFGDTFWVQKTGTAMGTPPAPMYATLYFAIHEHRILPSFSRELV-------EYGRYIDDGFGIWIPDPTLSDVDNDARWLSFQQAVNDYGRLTWEFTPRCSSLTFLDLFIELV----PHEPIRTSLYEKALNLYL-YLPPHSAHSPGMIRGLIIGQVRQIFLLTSTHGKRTELVRKLFLRLRARGYSRTMLLPLFNSALVLAESLLRPAPSASLSDSPPVADPVLFLHVQYHPLDVPTATLQQ---------------TFASTMLHPPGEPPLPDLRNRSFSRFGCNRLIVAYHRPRNLGNLLAPRRIRTTNDAPVSVILRDFDDPVGVINPDPLSLEP--------------------------------------------------------------------------------------------------------------------------------------------------------------------- PLE_ex_Selaginella_moellendorffii DIAGQRPVSKFENRVETGAVHNLSS--RALSAAEIRLLSLGXRYIPNPAPLRAPQIVESSDALCRAVRLRHLFKD-----------DDSALPEFRVPNPSFEP-------------------------------------------------------------PPAPAYVERRLA-HVRGSLLHRLEGAHKPRSFAHGWKKRAL------------HSLATDTSIVIKPADKNLGAVVLDRDWYTKEALRQLN-DPLVYVKV-PSVPSKSLQERLAELITKYRSCS--WLDNSTQQFLLHQP--AVPRQACMMYFLPKIHKQPI--------------------------------------------KGRPIASYIGTLWEPLARWLHRQLYDILL-KQPTFLSDSRTLLQDLLHLQLPRD-----CWLFTFDVESLYPSIPTREGLQRLRDFVFAEYGNTTRSR--------------FLMAAAALVLEHNYVEFDGNIYQQIRGTAMGSNFAVVYACLFLCSLEAEYKHATNDWPF-------YLRRYIDDGVGIWT--GTRAGLERWLRGYGT---LCPSIKITSVISL--EELDILDIHFFKGPRFEETGCLDSSTFQKPVNAYQ-YLPWTSVHPRHQKVAFIRSELRRYLLRESTADGFHAMRTRFYHRLRARGYPTSFLHHCFSGISYDQRHQALLARSRRSSDACRRAPLAFKLPYTLHSAQLGLGDILNPKQVMDE--------APTDTLPRVITCWRRSPNLGSFLVRAKLPP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ Penelope_ex_Aedes_aegypti TRNLQPAASDELPAHNPKAIHNGTQ--VTVPAETEVLLSLGPKFALPITLADQVP----------------------------------FYHLMADVEQIIKV--------------------------------------------------------------SNVTAAQD----QSRCAIANIITNYIHGSRNRSKEADPATKFFENAEA-ITRRFLKENPNVYIVKSDKGNKTVLIEAEDYKNKMMELLQ-DRSTYAPI-SRDPTSKYERYNNNLVRRLRDLE--IFDDRTAKQLTK-----YNAVCPRIYGQPKAHKPGL--------------------------------------------PLRPVLPNVTAPSYNLSKYIGKIFQQSLV--SKYNIKDSFSFCQFINSITLPED-----YVLISLDVKSLFTSIPKSLAISSIIMRWDEIKPNTTICL-------------DLFIEIVEFCIDSSYFRFEGQHYQKIFGTAMGNSLSPAIADWVMETLLDTLVRKLNIPLP-------FLRKFVDDLITAI---PLNQLQH-VLEVFNG---YDVHIQFTYELEV-DNKLPFLDMLLTRQ----NDQKITTQWYQKPIASGR-FLSFKSYHPLSQKLNMAVNFARRVSKLSTDLEERE-KVRLIDEHLKLNDYPKSLRHRIANRMNERTNDQQQ---------LENLEYTYRRMPFIP---HLSNRIDR----------------ALSRDYGNVKLAKYNVRSVREFFTKVK--DPVPSEQQ--------------------------------------------------------------------------TNVVYAIPCS-----NCEALYVGMTTNRLKTRIHGHQTRYNTMEKLLQRGIDVKDPQ----ITALGERTALT-HHSITKQNRFDLSKAKIVDRNENTETL--QFLEMWHIANNT-----NSINRRTDIERLHAIY Penelope_ex_Bombyx_mori DILIKQKINRHTLSSKSKHIYNYTD--VQLPTEVEMILNLEPKFGIEIKEKWKVI-----------------------------------PTVIKDLEFGIEA--------------------------------------------------------------VQLDDCNDE---GKDIVKNNLRSKAINVISNYYNKNDRLNHTVLIKNLYITRKFLKERPDLIVARADKGNTTVIMLKTEYDTEMRKMLN-DKVTYKLL-KKDPTNKWQKVANSLVNKLVVAK--IVEEQQGKHLKA-----KYTVAPRIYGLRKTHKETC--------------------------------------------CLRPVVSCVNSPSYSLARFLHEILTPVIE-KFQYNVKNSFDFVTFSRKVSLPKN-----YVLISLDVVSLFTNVRRDLILKVIEETWDNMKHLVKIPK-------------SVLVDLITFCYDSSYFVYQGEFYAQTEGSSMGNPASPVIANIVMNYVIDQILKILPFEIH-------FLKLYVDDTIAAI---PESEVNN-ILELFNS---FDNNIQFTMEVEK-DDSLSFLDVLVKRS----NDKLITD-WFVKPISSGR-LLNWNSNHPRSQKIGMIKGLLDRMTKLSSKDFYEV-NFNKIRNILLNNNYEMPLVDSVINKFKENLNNKTRSLVN-----SNNNNIRYCRFPYMA---ELSNKLNR----------------VFIGTHVRLAFYN--ILRVNSIYSKLK--DPVNKQQQ--------------------------------------------------------------------------TGIVYKIPC------SCDLCYIGQTRQYLSNRVKQHIYDCKNINILKANK------------TALATHHFDQ-HHNFEFDKIEILDKEMNWWKRN--------VSEMIFIKTND------TVNKRTDTNNLSILY Penelope_ex_Drosophila_virilis KLRDQRNLALADNNTQREWFVNKTK--IEFPPNVVALLAKGPKFALPISKRDFPL-----------------------------------LKYIADGEELVQT----------------------------------------------------------------IKEKET----QESARTKFSLLVKEHKTKNNQNSRDRAILDTVEQ----TRKLLKENINIKILSSDKGNKTVAMDEDEYKNKMTNILD-DLCAYRTL-RLDPTSRLQTKNNTFVAQLFKMG--LISKDERNKMTT-----TTAVPPRIYGLPKIHKEGT--------------------------------------------PLRPICSSIGSPSYGLCKYIIQILKNLTM-DSRYNIKNAVDFKDRVNNSQIREE-----ETLVSFDVVSLFPSIPIELALDTIRQKWTKLEEHTNIPKQ------------LFMDIVRFCIEENRYFKYEDKIYTQLKGMPMGSPASPVIADILMEELLDKITDKLKIKPR-------LLTKYVDDLFAIT---NKIDVEN-ILKELNS---FHKQIKFTMELEK-DGKLPFLDSIVSRM-----DNTLKIKWYRKPIASGR-ILNFNSNHPKSMIINTALGCMNRMMKISDTIYHKEIEH-EIKELLTKNDFPPNIIKTLLKRRQIERKK------------PTEPAKIYKSLIYVP---RLSERLTNSD--------------CYNKQDIKVAHKP--TNTLQKFFNKIK--SKIPMIEK--------------------------------------------------------------------------SNVVYQIPCGGDNNNKCNSVYIGTTKSKLKTRISQHKSDFKLRHQNNIQK------------TALMTHCIRS-NHTPNFDETTILQQEQHYNKRH--------TLEMLHIINTPTY---KRLNYKTDTENCAHLY Penelope_ex_Drosphila_willistoni KLNNKRNFALLNNNRTDDWFVNETE--LEFPPDIKSLLSKGPKFALPIEHEKLPL-----------------------------------IKYIADGEEIVQT----------------------------------------------------------------IKEKEK----QEAARTAFSLMVKEHRAMKYINATDRAILNTTQR----TYKFLKQHDDILILTSDKGNKTVAMKKIDYDHRMMDILS-DLNTYRIL-RKDPTTRLQTKNNNLVDKLHKM--GVISKIEKNRMTT-----TTAISPRIYGLPKIHKEGT--------------------------------------------PLRPICSSIGSPSYGLCKYIIQILRNITL-DSKYNIKNTTEFKQRINNTYICND-----EQLISFDVVSLFPSIPTDLALDTIRKKWTKIQEYTKIPKA------------LFMEIVKFCIQENRYFTYKDQTFIQLKGMPMGSPASPVIADIVMENLLDTTMDKLTRPPR-------LLTKYVDDIFSIIH--QDDIDK--TLDTLNS---FDRNIKFTMELED-NGKLAYLDSLVIRR-----GNELKLKWYRKPTASGR-IINFNSKHPKTMIINTARSCIQRMLNISDKIYHGETKM-EIINILKDNDFPDNVIRTLFKKHKSTNDK-------------TKNEKTYISVTYVP---KLSERLSHSD--------------CYDKDRIKIAHKP--DNTLKYVFNKTK--SKIEMTNR--------------------------------------------------------------------------SNVIYKIPCNGQGNIPCNKIYIGTTKSKLKTRISQHKSDYKMRHYTDTPK------------TALMTHCATS-GHAPNFEETTILDEERHYNKRF--------TMEMLYIINTPSA---TRLNFKTDTDNCAHIY Perere_ex_Euprymna_scolopes -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YISPQFPE---------------RIFVELMELATKSVSFSFNNIMYRQIDGISMGSPLGPSLANIFVGFLENELFSKITKPAF--------YTRYVDDTFACF---PSRSEAEQFLRLLCN---LHPSLQFTMEVED-CGSLPFLDVRVSKV-----GTTFETSVYRKPTFTGL-YLNWFSFAPQSRKIYLISALTHRALMICSLDRLDM-ELG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Perere_ex_Schmidtea_mediterranea KLINLRKIFGISKFSVENTVINLSK--IVLNDDEERVLKFGPNHCIKNRLDETK--------------------------------------LCAKIESLYFH--------------------------------------------------------------IARSMKGIN-GNYVKSSLSASTMEYIDKNKKQNIRDFMTL------------KNL-AKKNINICKFDKGNGIVILDHDVYVNKLNDLLN-S-PQFVKLPKGRKNGKLPPLKDEEFVQKMLNG--FIEKKLIDEEVGKSIRPIGSQPAKLYGLPKIHKDGV--------------------------------------------PMRPVLSMVGTAQYKIAKFLDGLLKPLMR--SEFECKDSFEFVSCIAKLQKRSMN----DVMVSFDVCSLFTNVPLVETIDLCCALWNENDSEHHILDR------------RAFRKLLEFATSNVNFLFNDEWYQQIDGVAMGSPLAPTMASIFLASLEKKIASFQFEKPF-------VYKRYVDDIFLIF---ENQKHVEPFLHFMNS---LHKNIVFTCETER-KSSIAFLDLLIQRK-----DKQYETEIYRKPTDTGL-YTSPESFCEFKYKRNMVKGLIYRSWSLSSTFANSVKSVDKLVELLIKNGYSKSFLLLMIKETVDKLIKNPKDPCF-----GKSECNLSNGCELSV---DLNNSKNGYKK-------------IEPKYVLVLPYSEGFTNYKRKLSKQMGNLEYKIVSNSCKVRNMFINKSKTPVGLC--------------------------------------------------------SDLVYQFTCN-----GCNATYIGETSRHLCTRVLEHCRLKGL--------------------TNISEHNRGC-KSEIGMSDFRILLRSFNNYWERV-------ICEALLIRSLD-----PKINVQSAVTTNVLNV Perere10_ex_Schistosoma_mansoni -------------------------------------LSLGPKFCDFKTVNKMDVEIQ------------------------------FENLYAQTAELVSSS--------------------------------------------------------------KDNVESFKS---TLVDCCFRYLNHGHSSKGILTNKHKEAL------------RKLKTNDNLLITKPDKGYGIVLMDKNNYINKMKAFLN-DQSKFQKLVVKNDLADKIEKQIIDSLKQIKQQG-FISEKVFEMLKS-----IGTRTPRLYGLPKIHKSGL--------------------------------------------PLRPVLDMNNSAYHTIAKWLMQILKPLHKEIVKHSVKDSFEFVNNIKNLSLKN------KFMISLDVTSLFTNIPLLETVDFICNELTERHTETVIPVT-------------AIKQLILRCTMNVQFRFDNEYYRQLDGVAMGSPLGPILADIFLAKLENGPLKDTISHLT-------SYCRYIDDTFIVL---EKEHEKENILNIFNN---IHPSITFTLEEEQ-NGSISFLDVQLTRR----IDGTLKRGLHRKST-VGQ-YTHFYRAVSIKXQXNLITMLNHRARMIXSDDIILD-ELVNIRKLLSRNGYPMKFIDKHMKEMKRRTRIP-----------TVMKKVLFLKLQFLKD--ATEEIVTWRLR-------------KAAQKTFNAVKLSNIFYNRPTIRTVNK--DKLSEFTI--------------------------------------------------------------------------SMCIYQFNCF------CGANYKRRTIRQVRQRIIEHYPSWLSK-------------------------------------------------------------------------------------------- Poseidon_ex_Anolis_carolinensis KFDKCRKQQPKPELDKSRTIINLTD--RQLTEDQVSILEKGGNFAVTTTRIPVEN-------------------------------------IIANVESAIYQ----------------------------------------------------------------LPEEEAE---EVRMETARILRNAKLPPSNITRKERQAI------------KDLNSDPEIIILPADKGNATVIMETKQYKEKIRQLL--DPTIYKKL-KQDPTNKITRKTNTLIKNSS------INFDIRQQLCKSE-----ALPPRLYGLPKIHKDSI--------------------------------------------PLRPIVSAIGSPTYNLAKFLATQLQTHIG-LTAHYIKDSTHFIEKISNLNLSTK-----DILISFDVVSLFTKVPVADTLTLIKQNFPED-----------------------ITALFHHCLTTSYFQWDTGFYEQKDGVAMGSPLSPVVANFYMEYFEKQALETAPKKPT-------VWFRYVDDTFTIWS--HGEEELSKFLDHLNS---IHPNIQFTMEKEK-EGKLPFLDVLVIRK----PNQQLGHTVYRKPTHTDR-YLHKNSNHHPSQKRSTIKALTDRAQRIC-EPHLLQGELNHLNWALQANGYSTTDIRRASRPRTSHESQ------------DKDPPRRKVFLPYIK---GTTDRIGK----------------LMKKHNLQTIYRP--TKKIQQMLRSAKDKRDPLS-----------------------------------------------------------------------------STGVYRIPCS------CGQVYIGTTKRSAQTRVKEHERHCRLIQPEK---------------SAIAEHLMNQPGHSILFENTEMLEHSNNYHVRL--------HREAIEIHKHV-----DNFNRKEETMKTNKIW Poseidon_ex_Branchiostoma_floridae QXTLHACSVDSRGIPTKVWVKNLSS--HTLSEPEKSLLSNGLNFAVTPQRIPTVD-------------------------------------IITETESAIRR--------------------------------------------------------------ARLPHKQAE---ALRTKVATTLKVSKPPANNITQEEQAAL------------KALSTNKDIIILPADKGRCTVVLDREQYDSKVQDLLS-DNNTYLPL-KKDPTPTFKAKITAALKELQDKK--AIDRKTYLKIYPT-----GEQSPAFYGLPKIHKKEV--------------------------------------------PLRPIVSSIGSVTYELSRFLADIIGPLVG-KSEHHIKNSADFVNKIKDIRVEED-----EIITSYDVCSLFTSIPPKRAVAVVRDFLESDTTLGERTSLSS----------KQICDLLELCLGCTYFVYNGQYYQQLHGCAMGSPVSPIVVNLYMERFETEALSTFPDTPPA------NWFRYVDDTFSRLK--KTNADK--FFQHINQ---IDDNIKFTQEMSQ-NNTLPFLDSKVIVE----EDGLINVDVYRKPTHTDQ-YLAFQSHHPLEQKLGVIKTLFHRADTIITSEEAKSNEHRHLKDALNKCGYRQWSFNKALKPSHESKKPSNSKPLD-----KKKKTVN-ATIPYIH---GVSEKLRR----------------ILQNFNIATNFKP--HSTLRQKLVHPK--DRVQKGTN--------------------------------------------------------------------------SDVIYRLKREGP---QCNDTYIGETSHTEARYKHTAGYSKWISSASTTH-------------SATQGHPSTE-YYDILTRTRCMNG-----------------CQEASTSDL-------TPL------------- Poseidon_ex_Ciona_intestinalis -MAWQIESSTGETLSNKDWVMNMSD--KELTPAQ-SVLSLGLNFAVSPDNVPWKQ-------------------------------------IVASIEKGL----------------------------------------------------------------VGQPLHIKS---LLQSKLVGCIRSHKTTTTNVPKSYLAAI------------RELQKDRSIVILSADKGNRAVVMNRTDYTAKLLELLK-DARTYKKL-ARNPTPSLERKVNNYVRRLRE----VLSYSEFRQLHC-----TDGRTPQLYGLPKVHKPDI--------------------------------------------PLRAIVSFIGSPSYMLAKFLAKIVAPLIG-NNSHHVRNSHEFAAEVRDMTIADG-----ECLVSFDVVSLFTNVPIPLAM-LVSGCVLTL-----------------------HVLRFRVHSTNK-----------CFGTAMGSPISVVIANVVIETIEEDALATFMHPPR-------YWKRYVDDTFAII---AAEQLHP-FLDHLNG---IEESIQFTLEREN-EGKIAFLDVEVSRD----KEGGMKTNVYRKPTHTNR-YLSFWSAHPIEHKKAVVRSLKHRAEALVSDPLRLQDEMKFIKDGLRYNSYPPWMVKWKPTQKPKEVTP------------TIAT----VILPYVP---GLSDTLRR----------------MLTDHGIKVYSKP--HTTLRSLLSHPV--ENQATEP---------------------------------------------------------------------------KGVVYLIPCG-----DCEGVYIGETGRALKTRLKEHRRDVAAKDASK---------------TALSKHSTVC-SHRVAFENVQILERETDLTKRL--------FLETLHIHKHR-----ECVNNKEQCTYFPTVY Poseidon_ex_Eptatretus_burgeri --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ARGSAPFQPK-------FWLRYVNDFFVLWQ--QGKTDVNTFLQRLNN---QHCNIKFTMEVEQ-QQSISFLDILITKA----PNGKPSHQVYRKPTHPDR-YLNCRSFHHPSTLQSVSSTLVRCACTISDKYN-LHRELRHITDVLKFNGYPAHKIITKPPRARG----------------PTPKARAYVALPFIG---CASHHLQW----------------ILKTANITVRSNANPPDFIGRLPKIHPNSRPYDHYPYPPEILIFLHCSLIRMYWYEN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Poseidon_ex_Fugu_rubripes TNPFSNHVTSLSDSQREKWVKNLSD--RELTQAEEEVLSKGLNFAVTPEEVPTVE-------------------------------------LITATETAIRN--------------------------------------------------------------NKLPEAEAE---QIRLKVTAALASAKPPTSNITNEEKRAI------------ASLAKDKNITILPADKGRCTVVLNTTDYDTKILSLLT-DTATYEKL-KRDPTSSYKKKVVDLLQNLEKDK--AIDRPQYYRLYP------GETIPCIYGLPKIHKPGT--------------------------------------------PLRPIVSSINSVTYNISKYLASILSPMVG-NTPHHIKNSQDFAQKVIGLTLLPE-----ETMVSYDVTSLFTCIPTASAVDTIHKHLLLDKNLTERTTLTP----------AQICTMLDLCLNTTYFQYREGFYRQKHGCAMGSPVSPIVANLYMEKVESQALTSFTGTAPS------HWFRYVDDTWVKI---QIQELEA-FSDHLNK---TDEHVKFTREEVK-GNSLAFLDCAVKIT----EDRNLTIEVYRKPTHTDQ-YLQFDSHHPLEHKLGVIRTLQHRAREIPTTSQGRKKEQNHIKTALKTCGYPDWAFTKTSRKQDLSKGEEER---------NKRRS---VSIPYLS---GVSEKFRR----------------ILQKHDIPVHFKP--SNTLRQRLVHPK--DKTPRPKQ--------------------------------------------------------------------------SNVVYAVQCQ----EKCKELYIGETKQPLHRRMAQHRRATSSGQD-----------------SAVHLHLKES-GHSFEDSQVRILAREDRWFERG--------VKEAIHVKLEK-----PSLNRGGGLRHFLSPT Poseidon_ex_Hydra_magnipapillata KFNSLNIISIPPTNLIKNPILNLSN--ISISHEQENLLSLGPQFIPTQNKIPFIDIIT------------------------------STEECALNIEKNVNV-----------------------------------------------------------------ERAEFL---RQNVSKTLTKYLRVKIDSNICKNQRLAI------------NELKNSTNIKLYPFDKGNGFAILNSDSAIQKIKEQLG-NCA-ISAV---DPTQKFLSLIQRTLSKLKKDK--KLDKKTYGKIYP-----SDAIPPRLYGCIKAHKSEKGY------------------------------------------PMQIIVSTIGTPPHKLSQHLVEIIQPTLN-KNECRVKNSSSFVSTAKEWFINDE------VQVSFDVINLYLSVPLDKATITIIDMLNKDRDDLIQRTKLSL---------VDIHKLIDLCISKCYFLWKDKIYILKNSGPIGLSIMVVLSEAYLQHIESNAIQQALNVNIAPK----TYKRYVDDSHARFT--NIDDANS-FLTLLNS---QDKSIQYTCEYENAQHQLNFLDVCISTN---HSLHKYEFSIHRKDAITN---VLIKPKSSILPNIAGIFKGFLAGAYKICSEHNIQDEINFLIKIFTENGHSYKQYSDIAKNYKYSTNPSCS---------QKFDTKNLVILPWVP---KLGLVLRR----------------EFRKVGVKTVFRF--GNPLINILCRNK--SKLPPNS---------------------------------------------------------------------------HPGVYQLNCT------CGACYIGETRKKISTRIQEHKNNVTKANWET---------------SGIVEHS----QHCNGKINWENPKTLSIISNNYIRK-----ICEAIEVQRVQCSK--PKENVLNRDNGNLVMT Poseidon_ex_Oikopleura_dioica KTLLSSSTAHKSP-TPIVALTNVTI--PQD------LLNL-LEYGIDLPIGGSPNDYKILTSLEKL----------------------TKNWTAYAEENNIDP---------------------------------------------------------------------FT--IDEAKSYLKVNFHLLRKCYNPQNRQKLLT------------TFLDQNPEVRFIKIDKSKNLELISHKDYSLKLNKQFN-N-AHFEKL-PRNPLTLDIKYFYTFLRKMEPY----ISKSTWHQITP------NYALKAAYGIIKRHKPNH--------------------------------------------PLRPIVSSKNSITSGIESYFVKILNKLLP-KIKYSFKSTQDFKKKFLIHRAKFNP--KTDWIISFDVESMYPSIPLDRIIPKIVDIIYSDPKNFFESETRDDVECEIMPRTIFEEIFTKTLRHFTAFSTESSFFRQKQGVAMGSQMSGIIANITMSLLEQDIIDNEIVNKNLK-----FYGRYVDDIICII---KKSEVPR-INHLINN---WDKNMNFTIEFAK-NHSLTYLDTRIYFD---QNTKFLELKQFQKPSKTDTLQNFEEAVSPLSQKIGLLSGEIYRANNTTTTPENLDHALKSLVKKFTANSYPVKLVKSKIKNIQDANFIPPEKD-------PNITHRFHLSLEYTSP--RVNKIAKTIAN-------------MIRKITPSYKVVL-AFKTLRLGQIITSRLKRKIEYNEK-------------------------------------------------------------------------SGICYKFLCS------CNKSYIGETLRTFHLRRLEHTRLRSNTAIKRHFSNCPIFQ------NEYENHINSP-EVTSEISEGNFAKTKFSILQSNLSQYTNRTLTESFLITLFK-----PTINEQTDYRKEICFL Poseidon_ex_Oryzias_latipes --QNLKKKQELKNTINDKWISNLSK--HTLSEAERSVLSHGLNYAITPKQIPYEE-------------------------------------FIVATELACEK---------------------------------------------------------------IQDPGEKA---ALRNEIAGILKTAKLPSSNITKEEIAAI------------HNLKNNREITILPADKGRTTVIMDTEQNEKQMNEMLQ-DRNTYEVL-KRDPTEAKKRKLKTILKQLQEEK--KIDKQTYNHLIPI-----VSIIPRIYDTPKIHKPGA--------------------------------------------PLRPIIDSMGSVTYNLSKFIADILKPLLG-NTDYHCENAKQLAEELKNTKMEAN-----EIFISHDVISLFTRAPVEVTLQIVXEQLTANKSLRKCTCLTV----------NDITQLLHLLTTSTYFQFCNTIYRQKEGFPMGDPLSATMCSFFMEDLEKKAITSAPEHCRPT-----LWKRYVDDILEKI---KAGHTQE-ITDHLNT-MDDTGQIKFTHEEK--KDNSNFLDINIRHM----ENKDIKIKVYRKPTHTDQ-YLLWTSEHPTTHKISVVRTLFERA-ELVTDGEDKTEEKKHIKNALTRCQYPQWAIKKGQTQVEQRKYKEVEKKNLR----KKTENKGMVALPYIR---GITHPKSH------------------EKTSINTPVKP--YKKLRQLLVHPK--DKIEQNKK--------------------------------------------------------------------------CNVIYEIPCH-----TCNKTYIGETGRTFITRKMEHQKECEKETNKILTRARRQQAVQENIKSAITDHCKQE-NHIMDWEKAKVLRTEGNRHRRW--------IMEAVEIRKRAH----TSMNRDEGAFLLSHTR Poseidon_ex_Petromyzon_marinus ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VHCLCARPPRLYGLPKIHKVDT--------------------------------------------PLRPIVSTISSPTYKLARFLSEILRPFTG-KTTSAVQNSTHLVSTIKGISLSPD-----DLLVSFDVVSLFTKVPVPDTIAIIEDLAHQGLN-------------------TEEPPLVRHCLTNTYFTWNGTFYKQTEGTPMGSPLSPVIANIFMEKFETDAIQTATLRPT-------LWKRYVDDTFVIWP--HGRPALDQFFDHINS---IHPAIRFTMEVEI-DGKIPFLDVLIKKR----PDGSMSHSVYRKATHTDA-YLKPDSHHHPSQKNSLIKTLYHRA-QCISDQEHISSELKHVHQALRANGYSDYTIRKAITQTMKKN--------------PLEEPFKTITFPYIA---GITKKISK----------------ILNKHKIQVRFNT--LHKIRDLVPSVK--DVIPDIQ---------------------------------------------------------------------------YPGVYKLSCL------CGSSYIGETKRHISDRIREHKADLKHGRTNT---------------SAVADHCSNS-VGSHAIDFSKTEVLCKPSGFHERF------VHEAIHIYKHR-----DNFNREDGFYLSNHWK Poseidon_ex_Strongylocentrotus_purpuratus LTQPKSSRTVPSLANEEKWVINLSS--RTITSSEEEILKKGLGFAVSPRRIPATE-------------------------------------IIAKVETAV----------------------------------------------------------------KYLDAESAD---AARRDVDNILQKARPPKHNISKEMHTAL------------KTLKADDSITILPADKGRATIILDTPIYHEKLTDLLE-S-GPYRVL-KKDPTDRLARKLTNTLLNLKKDN--VMDEPTYRRLKP-----TQKQPPRIYGLPKIHKPTV--------------------------------------------PLRPIVSCIGSFAYNLSKYLAEILSPLTG-LTEYTIPNSSGFAEFIAEQTIGTQ-----ERMVSFDVVSLFTNVPIEGACNATLQRLQSDSNLSTRTALSP----------EQLTQLLEFVLRSTYFLYKGSYYEQTEGAAMGSPVSAVVANLYMESFEEEALDTCPLSCIPL-----VWKRYVDDTFIIV---PISETDK-LLKHMNS---LEPTIQFTSEIEC-EGKIAFLDTLVHRH----DNHRLSTSVYRKPTHTDQ-YIAFDSHHPISVKRGLVKCLFDRASRIVTSPQQPCKERTRVRSALSLNGYPRRFIHNTKNRSSEPRDQ------------KVYKTFT--VLPYID---GVSQQLKR----------------RLESHGIRTVFRS--DTTLRQQLTRPK--DPIPPHRR--------------------------------------------------------------------------DGIVYNIPCK-----GCDRSYIGETARPIKERITEHKRDVRLRRTDN---------------SAVAEHAWDN-QHQPDWDGVQCLSQERHWYTQR--------VKEAINIRLNP-----NNFNRDNGIDIPEFWM Poseidon_ex_Xenopus_tropicalis EELTWRQKDETSKNTKDTWVKNLSD--RVLTQPEKDVLAKGLNYAVTPQHIPVVE-------------------------------------LITATESAINN--------------------------------------------------------------NHIKVEEAE---QLRLKVSAALSSARAPPSNLTTQERRAL------------TSLSKDPNITILPADKGRCTVVLNTTDYHCKMTSLLS-DSNTYEPL-RRDPSSSYKKKVIDCLQQLEKEE--AIDRALYHRLYP------REATPCLYGLPKIHKDGA--------------------------------------------PLRPIVSSINSVTYSIAKYLANILAPLVG-KTVHHIQNAKEFVTKIQGVKLEAE-----ETMVSYDVTSLFTCIPTTEATETVRNRLQKDDTLSSRTKLSP----------NQVCLLLDLCLNTTYFKYKDQFYRQKHGCAMGSPVSPIVANLYMEEVERKALLTFNGTTPS------HWFRYVDDTWVKI---RSNEVAA-FSEHINS---VDNNIKFTREDVH-ENKLAFLDCLISIQ----EGGILKTEVYRKPTHTDQ-YLLFDSHHPLEHKLGVIRTLHHRAESVTTDTESKDKECKHLRGALKACGYPDWAFVKTRATKPNRNTKRNNRPEA-----ERRRN---IVIPYVA---GVSEKLRR----------------IFNKHHIPVFFKP--SNTLRQKLVHPK--DPTPKEKQ--------------------------------------------------------------------------SNVVYAVQCSE----ECTDLYIGETKQLLSKRMAQHRRANTTGQD-----------------SAVFLHLKDK-GHSFENSNVQILDKEDRWFERG--------VKEAIHVKVEK-----PSLNR-GGGLRHHLSA ; END; BEGIN TREES; TITLE Tb8205; LINK TAXA = Taxa1; TRANSLATE 1 PLE_ex_Selaginella_moellendorffii, 2 Nematis_ex_Caenorhabditis_remanei, 3 Neptune_ex_Acropora_palmata, 4 PLE_ex_Phaeodactilum_tricornutum, 5 Nematis_ex_Pristionchus_pacificus, 6 Neptune2_ex_Reniera_sp_JGI2005, 7 Neptune1_ex_Reniera_sp_JGI2005, 8 Poseidon_ex_Anolis_carolinensis, 9 Neptune_ex_Anolis_carolinensis, 10 Neptune_ex_Hydra_magnipapillata, 11 Neptune_ex_Oryzias_latipes, 12 Poseidon_ex_Oryzias_latipes, 13 Penelope_ex_Drosphila_willistoni, 14 Osiris_ex_Tribolium_castaneum, 15 Neptune_ex_Nematostella_vectensis, 16 Neptune2_ex_Fugu_rubripes, 17 Neptune2_ex_Danio_rerio, 18 Neptune4_ex_Xenopus_tropicalis, 19 Neptune3_ex_Xenopus_tropicalis, 20 Neptune1_ex_Xenopus_tropicalis, 21 Neptune2_ex_Xenopus_tropicalis, 22 Cercyon_ex_Schistosoma_japonicum, 23 Poseidon_ex_Branchiostoma_floridae, 24 Osiris_ex_Penaeus_monodon, 25 Perere_ex_Euprymna_scolopes, 26 Poseidon_ex_Eptatretus_burgeri, 27 Neptune_ex_Anolis_sagrei, 28 Neptune_ex_Sphenodon_punctatus, 29 Nematis_ex_Caenorhabditis_sp4, 30 Poseidon_ex_Hydra_magnipapillata, 31 Poseidon_ex_Ciona_intestinalis, 32 Poseidon_ex_Petromyzon_marinus, 33 Nematis_ex_Caenorhabditis_briggsae, 34 Poseidon_ex_Oikopleura_dioica, 35 Perere10_ex_Schistosoma_mansoni, 36 OsirisC_ex_Aedes_aegypti, 37 Penelope_ex_Aedes_aegypti, 38 OsirisE_ex_Aedes_aegypti, 39 OsirisB_ex_Aedes_aegypti, 40 Penelope_ex_Bombyx_mori, 41 OsirisD_ex_Aedes_aegypti, 42 Neptune3_ex_Fugu_rubripes, 43 Perere_ex_Schmidtea_mediterranea, 44 Cercyon_ex_Schistosoma_mansoni, 45 Poseidon_ex_Xenopus_tropicalis, 46 Poseidon_ex_Strongylocentrotus_purpuratus, 47 Neptune1_ex_Danio_rerio, 48 Neptune_ex_Fugu_rubripes, 49 Poseidon_ex_Fugu_rubripes, 50 Penelope_ex_Drosophila_virilis; TREE Fig._5 = [&R] ((((((((50,13),(40,37)),((31,((46,(12,(23,(49,45)))),(26,(32,8)))),(44,22))),((34,(43,(35,25))),(30,(14,(39,(38,(41,36))))))),24),(5,(33,(29,2))))'Penelope-Poseidon Group',(10,(((6,(7,(42,(48,(16,11))))),(15,3)),(((47,(21,17)),(19,(20,18))),(28,(27,9)))))Neptune_Group),(4,1)); END;