Elena Beisswanger
MHC
David S. DeLuca
2008-03-07
MHC genes, alleles, and molecules in human, mouse, and dog
Jena University Language and Information Engineering (JULIE) Lab at Friedrich-Schiller-University Jena, Germany
Department of Transfusion Medicine, Hannover Medical School, Hannover, Germany
Variants of genes found in the MHC Class I region
A variant of an MHC gene
MHC allele
human MHC protein
HLA DQ molecule
beta subunit of MHC class II molecule
DP alpha chain
DLA DPA allele
TAP allele
Transporter associated with antigen processing
H 2 E allele
DLA DRB 1 allele
DR beta chain
H 2 A allele
The Immuno Polymorphism Database (http://www.ebi.ac.uk/ipd/)
dog MHC allele
A variant of a canine MHC gene
polypeptide
Multiple amino acids bound together by peptide bonds
SO:0000104 polypeptide
CHEBI:16670 peptides
mouse MHC allele
MHC class I non-classical allele
Belonging to the so-called non-classical HLA
human
TaxonomyID:9606 Homo sapiens
H 2 DM allele
H 2 class ia allele
DLA 12 a allele
Class I pseudogene associated with 12kb Hind III fragment
HLA F molecule
DLA DQA 1 allele
DQ alpha chain
DLA class ia allele
protein strand
A single polypeptide which is the direct result of tranlation of an mRNA sequence
SO:0001063 immature_peptide_region
CHEBI:16541 protein polypeptide chains
Kennedy LJ, Altet L, Angles JM, Barnes A, Carter SD, Francino O, Gerlach, JA, Happ GM, Ollier WER, Polvi A, Thomson W, Wagner
Nomenclature for factors of the Dog Major Histocompatibility System (DLA), 1998: First report of the ISAG DLA Nomenclature Committee
Tissue Antigens (1999) 54:312-21
Animal Genetics (2000) 31:52-61 (parallel publication)
DLA allele
A variant of a canine MHC gene whose function is to bind peptides and present them on the cell surface
TaxonomyID: 7776 Gnathostomata
organism
MHC class I classical allele
MHC class Ia allele
allele
Mutually exclusive alternative forms of the same gene occupying the same locus on homologous chromosomes, differing in DNA sequence and governing the same biochemical and developmental process. [NCI:C16277]
SO:0001023 allele
NCI:C16277 Allele
H 2 L allele
mouse MHC protein
A variant of an MHC gene whose purpose is to encode a peptide presenting protein. This class is used to distinguish between alleles of the MHC region which present peptides, and those with other functions such as TAP or LMP
MHC allele encoding antigen presenting protein
IEDB: MHC Molecule
MHC protein
beta 2 subunit of MHC class I molecule
DO beta chain
DLA DOB allele
DLA class II allele
A DLA allele which is a variant of a gene from the MHC class II region
Class I processed gene associated with 2.6kb Hind III fragment. Not in DLA region
C 1 pg 26 allele
DLA DQB 2 allele
Pseudogene?
DLA 53 allele
Class I pseudogene associated with 5.3kb Hind III fragment
Variant of a pseudogene
HLA K molecule
TaxonomyID:9615 Canis lupus familiaris
dog
DLA DRA 1 allele
DR alpha chain
MHC Class2 Protein
HLA Class2 Receptor
H 2 D allele
H 2 T allele
Allele found in the MHC class I region and incoding the alpha chains which form together with beta2-microglobulin, peptide presenting proteins
MHC class I allele
protein
CHEBI:36080 proteins
H 2 allele
IMGT loci: Mouse (Mus musculus) MHC H2
DLA DRB 2 allele
DRB pseudogene
alpha subunit of HLA DP molecule
protein coding gene
DLA null allele
The so-called "classical" HLA class I alleles
The Class II region is a portion of the MHC gene complex, which contains Class I peptide presenting genes, as well as other genes which enocode proteins which do present peptides on the cell surface, such as TAP
DLA DQB 1 allele
DQ beta chain
SO:0000704 gene
gene
H 2 M allele
human leukocyte antigen
HLA molecule
H2 null allele
H 2 P allele
HLA E molecule
DLA class ib allele
H 2 O allele
MHC protein strand
Polypeptide sequences resulting from the translation of genes found within the MHC
Any gene found within the major histocompatibility complex
MHC gene
H 2 class II allele
beta subunit of HLA DP molecule
HLA J molecule
Class I gene associated with 8.8kb Hind III fragment
DLA 88 allele
HLA G molecule
An Allele with the effect of either abscence of the gene product at the molecular level, or the absence of function at the phenotypic level.
null allele
A variant of a gene found in the MHC Class II Region
alpha subunit of MHC class I molecule
DLA DPB 1 allele
DP beta chain
HLA DP molecule
Polypeptide sequences resulting from translation of genes within the human MHC
HLA class I receptor
HLA class I antigen
HLA H molecule
DLA A allele
Molecular characteristics unknown.
HLA L molecule
H 2 class I allele
MHC multi strand protein
DLA 79 allele
Non-classical class I gene associated with 7.9kb Hind III fragment. Not in DLA region
HLA DO molecule
MIC allele
Class I chain-related allele
jawed vertebrate
TaxonomyID:7776 Gnathostomata
dog MHC protein
H 2 K allele
MHC class III allele
Alleles in coded in the Class III region of the MHC, found between the Class I and Class II regions.
Non-classical class I gene associated with 6.4kb Hind III fragment
DLA 64 allele
HLA C molecule
H 2 class ib allele
MHC null allele
A variant of an MHC gene containing a mutation which dramatically alters the peptide sequence which is encoded
Non-classical class I gene associated with 12kb Hind III fragment
DLA 12 allele
A nonfunctional gene sequence that is related to a known gene but cannot be transcribed or translated due to mutations.
SO:0000336 pseudogene
pseudogene
DP beta chain
DLA DPB 2 allele
A DLA allele which is a variant of a gene from the MHC class I region
DLA class I allele
2
multi strand protein
HLA DR molecule
The Class I region is a portion of the MHC gene complex, which contains Class I peptide presenting genes, as well as other genes which enocode proteins which do present peptides on the cell surface, such as MICA
nucleotide sequence
CHEBI:33696 nucleic acid
A representation of a nucleotides which are bound together as part of a macromolecule
HLA DM molecule
TaxonomyID:10090 Mus musculus
mouse
HLA A molecule
MHC class II allele
Allele found in the MHC class I region and incoding either the alpha or beta chains of peptide presenting protein
H 2 Q allele
alpha subunit of MHC class II molecule
HLA B molecule
Reference to a similar term in an external database or terminological resource.
Textual definition explaining the meaning of a class or property. If the definition was taken from an external resource a reference is given in brackets.
PAL-CONSTRAINT
DIRECTED-BINARY-RELATION