Molecular mechanisms of inherited hypocholesterolaemias: impact of APOB and MTTP mutations on lipoprotein assembly and secretion [ 2011 - 2013 ]

Research Grant

Researchers: A/Pr Amanda Hooper (Principal investigator) ,  Prof Frank Van Bockxmeer ,  Prof John Burnett

Brief description Inherited low cholesterol levels can be caused by mutations in either of two genes: APOB and MTTP. These genes encode proteins that are critical for the assembly of fat particles in the body. We plan to use cell lines to study how single amino acid changes out of the 4500 in ApoB and the 900 in the MTTP protein affect protein production, binding with other proteins, and fat particle assembly.

Funding Amount $AUD 200,213.75

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant