A Pharmacological Targeting Approach Implementing Albumin as a Carrier of a Novel Chemotherapeutic [ 2013 - 2015 ]

Research Grant

Researchers: Dr Danuta Kalinowski (Principal investigator) ,  Dr Darius Lane ,  Dr David Lovejoy ,  Dr Yohan Suryo Rahmanto ,  Prof Prem Ponka

Brief description New drugs for cancer therapy are essential to develop that overcome resistance to standard chemotherapeutics. We have developed potent anti-cancer chelators that bind to the abundant plasma protein, albumin. Our studies showed increased tumour cell uptake of the chelator, Dp44mT, mediated by albumin. We will elucidate the mechanisms of their albumin-mediated uptake, with the aim to implement albumin nanoparticles as carriers of novel chelators to selectively target tumours.

Funding Amount $AUD 560,659.33

Funding Scheme Project Grants

Notes Standard Project Grant