grant

HIV-1 transcriptional gene silencing by promoter targeted si/shRNAs: uncovering mechanisms, optimising delivery systems, assessing in vivo efficacy. [ 2013 - 2016 ]

Also known as: Silencing HIV by inducing prolonged latency through small RNA constructs

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1049473]

Researchers: Prof Anthony Kelleher (Principal investigator) ,  A/Pr Stuart Turville Dr Kazuo Suzuki Prof Geoffrey Symonds

Brief description Current therapy for HIV is effective but must be taken for life. If therapy is stopped the virus comes back immediately from reservoirs not affected by current drugs. These fluctuating levels of virus are associated with increased illness and death. We are exploring a method of inducing prolonged viral latency using short double stranded RNA molecules. We propose to understand the mechanism of action of these possible therapeutics and to develop these constructs towards use in clinical trials.

Funding Amount $AUD 641,789.55

Funding Scheme Project Grants

Notes Standard Project Grant

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