Persistent firing in cortical interneurons: mechanisms and potential anticonvulsant role [ 2013 - 2016 ]

Research Grant

Researchers: Prof John Bekkers (Principal investigator) ,  Dr Mark Mcdonnell ,  The Australian National University (Managed by)

Brief description The normal brain treads a fine line between too much electrical activity (epilepsy) and too little (sedation). We have discovered a class of brain cell that seems to behave like a sentinel, monitoring brain activity for signs of epilepsy. If a seizure occurs, this cell switches on an electrical brake that dampens excess activity. In this project we will study how this brake works and whether it really can inhibit seizures. Our research may lead to better treatments for epilepsy.

Funding Amount $AUD 520,552.26

Funding Scheme Project Grants

Notes Standard Project Grant