grant

Characterising the topology and function of the human m5C RNA methylome [ 2014 - 2017 ]

Also known as: The study of RNA modomics

Funded by National Health and Medical Research Council
Managed by Australian National University
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1061551]

Researchers: Prof Thomas Preiss (Principal investigator)

Brief description The role of the modified base 5-methylcytosine (m5C) as an epigenetic mark in DNA is well appreciated and intensely studied. By comparison, the cellular functions of the same base modification in RNA molecules, which function as working copies of the DNA genome, are poorly understood. This project will apply next generation sequencing technology to chart the occurrence of m5C in eukaryotic cellular RNAs and endeavour to unravel its function(s) in human biology and cancer.

Funding Amount $AUD 602,537.06

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Biological Sciences | Genetics | Gene Expression (Incl. Microarray and Other Genome-Wide Approaches) | RNA metabolism | RNA processing | bioinformatics | cytosine methylation | epigenetics | eukaryotic gene expression | gene regulation | messenger RNA (mRNA) | protein synthesis | sequencing |
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