grant

The role of UPF3B and nonsense mediated mRNA decay surveillance in the pathology of intellectual disability. [ 2014 - 2017 ]

Also known as: UPF3B and NMD in brain function.

Funded by National Health and Medical Research Council
Managed by The University of Adelaide
Managed by University of Adelaide
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1063808]

Researchers: Prof Jozef Gecz (Principal investigator) ,  Dr Lachlan Jolly ,  Prof Miles Wilkinson

Brief description Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundamental importance.

Funding Amount $AUD 789,954.47

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Biological Sciences | Genetics | Neurogenetics | RNA | autism spectrum disorders | expression profiling | gene expression | gene function | gene identification | intellectual disability | neurogenetics |
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