grant

Chemical biology investigation of cell death processes: development of molecular probes interfering with necroptosis [ 2014 - 2016 ]

Also known as: Investigating cell death processes with small molecule probes

Funded by National Health and Medical Research Council
Managed by The Walter and Eliza Hall Institute of Medical Research
Managed by Walter and Eliza Hall Institute
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1067289]

Researchers: A/Pr Guillaume Lessene (Principal investigator) ,  A/Pr James Murphy

Brief description Necroptotic programmed cell death has a key role in maintaining healthy tissue, and dysregulation of this process is associated with the pathology of infection and a range of chronic inflammation diseases for which there are few satisfactory treatments. In this project, we will discover small, drug like, molecules that interfere with the necroptosis pathway. These small molecules have the potential to become new therapeutics to treat these inflammatory diseases and will be invaluable probes to study this key biological pathway.

Funding Amount $AUD 630,736.95

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Biologically Active Molecules | Chemical Sciences | Medicinal and Biomolecular Chemistry | cell death | inflammatory arthritis | inflammatory bowel disease (IBD) | kinase inhibitors | kinases | medicinal chemistry | necrosis | signal transduction |
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