Reversal of diabetes in a humanised mouse using a clinically applicable vector system [ 2015 - 2018 ]

Research Grant

Researchers: Prof Ann Simpson (Principal investigator) ,  A/Pr Bronwyn O'Brien ,  Prof Ian Alexander

Brief description Somatic gene therapy is one of the strategies that is being considered to cure Type I diabetes. Specifically, we wish to engineer liver cells to replace beta cell function. The aim of this project is to design a clinically-applicable protocol for the reversal of diabetes using a recombinant adeno-associated vector that delivers genes to human livers with high efficiency showing long term expression without pathogenicity and immunogenicity following a simple intra-peritoneal injection.

Funding Amount $AUD 842,173.28

Funding Scheme Project Grants

Notes Standard Project Grant