Investigating the Molecular Basis for Drug Resistance and Disease Relapse in Myelodysplastic Syndromes [ 2018 - 2020 ]

Research Grant

Researchers: Prof John Pimanda (Principal investigator) ,  A/Pr Jason Wong ,  Dr Karen Mackenzie ,  Dr Peter Campbell ,  Dr Russell Pickford
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Brief description Myelodysplastic Syndromes (MDS) are a group of blood stem cell disorders that result in low blood counts and leukemia especially in the elderly. Azacitidine (AZA) is a drug that improves blood counts and delays progression to leukemia and is the treatment of choice. However, only half the patients treated with AZA ever respond and half of the responders relapse within a year. We will describe the origins of MDS and the basis for drug response, resistance and disease relapse.

Funding Amount $AUD 732,672.30

Funding Scheme Project Grants

Notes Standard Project Grant