Identification of therapy-resistant cells driving relapse in Medulloblastoma from integrated spatial transcriptomics and tissue imaging [ 3/1/2021 - 2/29/2024 ]

Research Grant

Brief description Medulloblastoma (MB) is the most common cause of cancer related mortality in children, with relapsed MB nearly a universally fatal event. Relapsed MB can be caused by pre-existing rare cells that escape treatment and continue to evolve. This project will identify the organisation of all cell types within patient derived xenograft models of MB, monitoring how this changes throughout tumour progression and drug treatment. We will identify rare cells responsible for driving recurrence.

Funding Amount $749,272

Funding Scheme Ideas Grants

Chief Investigator Dr Quan Nguyen

Notes Ideas Grants